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Home » Newsletters » BioWorld Science

BioWorld Science

Aug. 30, 2022

View Archived Issues
respiratory-lung-COPD.png

Airway microbiome regulates chronic obstructive pulmonary disease

A metabolite derived from the airway microbiome, indole-3-acetic acid (IAA), could become a potential therapeutic candidate for chronic obstructive pulmonary disease (COPD). Researchers at South China Normal University (SCNU) have shown how IAA prevents lung function decline by reducing inflammation, apoptosis and emphysema through IL-22 in the interaction between macrophages and alveolar epithelial cells. Read More

CSMD1 expression is linked to poor prognosis in patients with glioma

The prognostic role of complement inhibitor CSMD1 was assessed in 1,507 patients with glioma from three different datasets. Results of the bioinformatical analysis suggested that high expression of CSMD1 was associated with increased overall survival and disease-free survival, as well as lower tumor grade. Read More
Lab glassware and scientist

Applied Pharmaceutical Science divulges RET inhibitors

Applied Pharmaceutical Science Inc. has described new proto-oncogene tyrosine-protein kinase receptor Ret, (V804M mutant) and (G810R mutant) inhibitors reported to be useful for the treatment of cancer and irritable bowel syndrome. Read More
Multiple myeloma illustration

BMF-219 demonstrates efficacy in DLBCL and MM preclinical models

Researchers from Biomea Fusion Inc. presented preclinical data for the novel covalent menin inhibitor, BMF-219, after being evaluated in models of diffuse large B-cell lymphoma (DLBCL) and multiple myeloma (MM). Read More

Shanghai Apeiron Biotechnology synthesizes new TIPARP inhibitors

Shanghai Apeiron Biotechnology Co. Ltd. has disclosed triheterocyclic compounds acting as protein mono-ADP-ribosyltransferase TIPARP inhibitors and thus reported to be useful for the treatment of cancer. Read More
Lab research with pipette, microsope

Yaoya Technology patents new BTK inhibitors

Yaoya Technology (Shanghai) Co. Ltd. has disclosed tyrosine-protein kinase BTK inhibitors reported to be useful for the treatment of cancer, rheumatoid arthritis, lupus erythematosus, lupus nephritis, multiple sclerosis, asthma and Sjogren's syndrome. Read More

GI Cell collaborates with HK Inno.N to research and develop CAR-NK candidates

GI Cell Inc. has entered into a research and development collaboration for allogeneic chimeric antigen receptor (CAR)-natural killer (NK) candidates with HK Inno.N Corp. Read More
Human NK cell

Onk Therapeutics presents data on CD38-targeting ONKT-102 CAR-NK cells for MM

Chimeric antigen receptor (CAR) T-cell therapy is effective in the treatment of multiple myeloma (MM), but its toxicity and complex manufacturing limit their broad use. Read More

Scinnohub Pharmaceutical identifies new plasmin inhibitors

Scinnohub Pharmaceutical Co. Ltd. has presented plasmin inhibitors reported to be useful for the treatment of hemorrhage. Read More

Anti-C1q Fc-muTP-L309C is a potent modulator of classic component pathway activation

Researchers from CSL Behring LLC have investigated the inhibitory properties of an rFc hexamer, named Fc-muTP-L309C, as a modulator of the classic component pathway activation. Read More
pill over molecule structures

Nimbus Therapeutics details discovery, discloses structure of selective TYK2 inhibitor NDI-034858

The structure of a potent and selective TYK2 inhibitor, NDI-034858 (NTX-973), which was found clinically effective in autoimmune and inflammatory diseases, was disclosed for the first time by researchers from Nimbus Therapeutics LLC. Read More

Stemcyte cleared to study umbilical cord blood stem cell therapy for post-COVID syndrome

Stemcyte Inc. has received IND approval from the FDA for a phase II trial using umbilical cord blood stem cell therapy for post-COVID syndrome, or long COVID. Read More

Hepagene Therapeutics patents new HBV antivirals

Hepagene Therapeutics Inc. has divulged compounds reported to be useful for the treatment of hepatitis B virus (HBV) infections. Read More
Coronavirus variants

Polytope TATX-03 neutralizes SARS-CoV-2 variants of concern in live virus assay

Immunoprecise Antibodies Ltd.'s Polytope TATX-03 antibody combination therapy has been shown to neutralize SARS-CoV-2 variants of concern, including the omicron BA.5 subvariant, in an authentic virus assay. Read More

TQS-168 demonstrates geroprotective effects in mice

Tranquis Therapeutics Inc. has announced preclinical data on the antiaging effects of TQS-168, a small-molecule modulator of PGC-1alpha (peroxisome proliferator-activated receptor-gamma coactivator 1-alpha). Read More

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