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BioWorld Science

Nov. 28, 2001

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Water-soluble MMP inhibitors with potent, broad-spectrum activity

Ro-0098557: a development candidate with strong parenteral and oral antifungal activity in rats

Active Biotech signs benzamide licensing agreement with Oxigene

European Commission extends pramipexole's indications to include initial monotherapy

DGI BioTechnologies receives milestone payment for role in discovery of mimics of insulin

OncoGenex and Isis collaborate on antisense drug for prostate and other cancers

Potent TNF-alpha inhibitor selected as potential antiarthritic agent at Sumitomo

Initial phase I study for HE-2200 completed; clearance given for further study

Antiapoptotic agents targeting caspase 3 designed by Yamanouchi, presented in Kyoto

Promising antifibrillatory profile described this week in Kyoto for new piperidine derivative

Synthesis and antibacterial activity of alpha-substituted acylides presented by Taisho group

Preclinical profile of new NK1 antagonist suggests potential in emesis and depression

RARalpha-selective agonist undergoes early clinical testing in cancer patients

Two-year extension to Pharmacopeia and Otsuka collaboration

Phase II trial of GVAX cancer vaccine for acute myelogenous leukemia set to commence

Exelixis delivers further cancer targets to Protein Design Labs

FDA approves expanded use of Myoview

NDA submission for Alprox-TD in Singapore

Adenovirus-mediated PTEN gene transfer effective against human colorectal cancer

Orphan drug status granted for IL-13-PE38 for the treatment of malignant glioma

Pyrrolopyrimidine tyrosine kinase inhibitors claimed by BASF

Lilly compounds acting as kainate receptor antagonists specifically claimed for epilepsy

TNF-alpha production inhibitors and potential uses thereof described by Chugai

Novel therapeutic agents for schizophrenia and anxiety designed at Knoll

AstraZeneca presents CDK inhibitors in recent patent

Estrogen receptor modulators reported by Akzo Nobel scientists

Boehringer Ingelheim synthesizes compounds useful for inhibiting IL-2 production

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