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BioWorld Science

March 1, 2010

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Truvada well tolerated in HIV-1-infected pregnant women and neonates

QNL-111 shown to inhibit HIV-1 DNA integration

Vicriviroc does not meet primary endpoint in two phase III trials in HIV

C5A inhibits HIV-1 and HSV in preclinical studies

Pfizer describes novel kappa opioid receptor antagonists

Novel serotonin 5-HT6 receptor antagonists patented by Janssen

Bristol-Myers Squibb discloses new transcription factor AP-1 inhibitors

Merck KGaA identifies novel PDK1 inhibitors

Ambit Biosciences claims novel Janus kinase inhibitors

Novel dual PI3K alpha and mTOR inhibitors described by S*BIO

Resverlogix activates first site in phase II ASSURE 1 trial of RVX-208 in ACS

Fourth quarter highlights at Merck & Co.

Adeona completes 50% of enrollment in Trimesta trial in multiple sclerosis

GlycoVaxyn begins clinical trial of bioconjugate GVXN-SD-133 Shigella vaccine

Akebia initiates phase Ib trial of AKB-6548 for anemia

Fluticasone nasal spray ineffective in irritant rhinitis in pilot trial

TMTI awards SIGA contract for development broad-spectrum antiviral ST-669

Global Health Ventures to begin European trials of X-Excite for erectile dysfunction

Corcept Therapeutics begins phase I CORT-108297 trial

Rockwell Medical reports phase IIb data on soluble ferric pyrophosphate

Johnson & Johnson reviews fourth quarter of 2009

Actelion reports on BUILD-3 trial of bosentan in idiopathic pulmonary fibrosis

FDA issues refuse to file letter to Adventrx on vinorelbine NDA

Virginia G. Piper Cancer Center and TGen begin phase I trial of Pharmacyclics' PCI-32765 in cancer

FDA grants marketing approval for Shire's VPRIV for type 1 GD

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