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BioWorld Science

Aug. 25, 2017

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Novel beta-secretase 1/2 inhibitors identified at Merck & Co.

Lilly discovers novel phosphodiesterase PDE1 inhibitors

Amino-terminal fragment of the Par-4 protein overcomes therapy resistance in tumors

TWIST2 and SPOCK1 are essential regulators of human brain metastasis-initiating cells

Unum receives IND clearance to study ACTR-087 in combination with SEA-BCMA for multiple myeloma

Pfizer describes potent MAGL inhibitor for neuroinflammation

LE-004, an Mdm2-degrading PROTAC for the treatment of cancer

Karus initiates phase I study of HDAC6 inhibitor KA-2507 in solid tumors

FDA clears IND for phase I/II trial of Titan's ropinirole implant for Parkinson's disease

Five AstraZeneca anesthetic medicines transferred to Aspen in Canada

FDA grants orphan drug designation to SENS-401

New drug application filed for obinutuzumab in Japan

Curtana completes pre-IND meeting with the FDA regarding development of CT-179

Fujiyakuhin describes novel bisphosphonates

GPCR19 agonists patented by Universite de Droit et Sante de Lille, Institut Pasteur de Lille, INSERM

Savira, European Molecular Biology Laboratory discover novel compounds for influenza

EA Pharma divulges new TRPA1 antagonists

Ultragenyx submits BLA for burosumab to treat X-linked hypophosphatemia

Cancer Research UK initiates trial of LY-3143921 hydrate in solid tumors

Topline results from phase III study of daratumumab in front-line multiple myeloma

Bristol-Myers Squibb describes discovery of antithrombotic macrocyclic FXIa inhibitors

Bioverativ and Invicro form imaging collaboration to improve joint disease management in hemophilia

Aequus receives FDA feedback on plans to seek abbreviated 505(b)(2) pathway for AQS-1301

Apellis' phase II study of APL-2 in geographic atrophy meets primary endpoint

FDA approves Gocovri to treat dyskinesia in Parkinson's disease

FDA and EMA accept Vertex's submissions for tezacaftor/ivacaftor for cystic fibrosis

European Commission approves adalimumab biosimilar Imraldi

IDRI partners with Hisun to continue development of inhalable CPZEN-45 for TB

Protagonist Therapeutics closes license and collaboration agreement with Janssen for PTG-200

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