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BioWorld Science

Nov. 13, 2018

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Inhibitor of alphavbeta6 integrin prevents pre-established biliary fibrosis in BALBc.Mdr2-/- mice

Pulmonary delivery of mRNA encoding antibodies protects mice from RSV infection

MCR1-targeting PET and fluorescence imaging probes for melanoma developed

Mutant c-KIT inhibitor AZD-3229 is equivalent or superior to existing inhibitors in GISTs

Newly identified cell type precedes mast cells in anaphylaxis cascade

RetiPharma secures funding to prepare RP-001 for proof-of-concept study in retinal detachment

Hemostemix develops ACP-01 allogeneic process, begins R&D for NCP-01

Clinical data presented for JNJ-64530440, a novel HBV capsid-assembly modulator, in healthy subjects

MSC-derived EVs reduce inflammatory response and scarring after traumatic spinal cord injury in rats

AN-317, a drug candidate for PD, demonstrates efficacy in vivo

China SFDA clears phase I trial of A-319 in B-cell malignancies

Promising interim results presented from phase IIa study of CTP-543 in patients with alopecia areata

Results from phase IIa study of Zimura plus Lucentis in wet AMD

Swedish Medical Products Agency allows initiation of phase I trial of ROSgard

KalVista designs enlarged phase II study for KVD-900 in HAE

Exploratory clinical studies of NYX-2925 show NMDAr-mediated pharmacodynamic activity

FDA clears PolyPid to begin phase III study of D-PLEX[100]

QBiotics reports first-in-human data for tigilanol tiglate in solid tumors

Effects of tenofovir and tenofovir/levonorgestrel vaginal rings on vaginal microbiota and mucosal PK

Novel rBCG:HIV vaccine candidates with a ChAd.HIV boost show safety and immunogenicity in vivo

sFRP3 as a novel therapeutic target in Alzheimer's disease

Novel HBV capsid formation inhibitor, CB-HBV-001, demonstrates promising safety and PK in vivo

First patient enrolled in phase IIa ALICE study of iadademstat in AML

Nightstar Therapeutics updates status of NSR-RPGR program in X-linked retinitis pigmentosa

Sutro plans phase I trial of STRO-002 following FDA conclusion of IND review

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