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BioWorld Science

March 29, 2019

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Novel optimized allosteric SHP2 inhibitors that modulate MAPK signaling

Curl therapeutic RNA up into ball

The many shapes of tauopathy

Cathepsin S has a pathogenic role in CF and smoke-induced COPD: a potential target for lung diseases

Novel small-molecule RXFP3/4 agonist increases food intake in vivo

FT-113 shows promising antitumor activity in preclinical models

NLRP3 antagonist IFM-2427 enters first-in-human trial

Propellon Therapeutics discovers WDR5/MLL1 interaction inhibitors

New Toll-like receptor 7 agonists identified at BioNTech

Bioardis patents fibroblast growth factor receptor 4 inhibitors

Phase III PATENCY-2 trial of vonapanitase does not meet its coprimary endpoints

New ALK gene translocation found in gynecologic clear-cell carcinoma

Velicept presents positive topline results from VEL-2002 study of solabegron

Promising preclinical and first-in-human data presented for PRI-002

VALZ-pilot as the first clinical study to evaluate antiviral valaciclovir for the treatment of AD

NIAID initiates phase I study of inactivated subunit H5N1 influenza vaccine

Researchers identify new mutations in uveal melanoma

Phase II study of Foxy-5 as neoadjuvant therapy in Wnt-5a low colon cancer

Cimzia becomes the first and only FDA-approved treatment for nonradiographic axial spondyloarthritis

Odonate Therapeutics initiates CONTESSA TRIO phase II study of tesetaxel

Gilead Sciences and Galapagos present updated results for phase III studies of filgotinib

Pannexin 1 channelopathy causes human oocyte death

Orchard Therapeutics presents new registrational data for OTL-200 in MLD

First patient dosed in ReCLAIM-2 phase II study of elamipretide in AMD

Positive expression results presented from the casimersen arm of the ESSENCE study