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BioWorld Science

April 9, 2019

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Fully human stem cells show heart muscle regeneration promise

Recombinant immunotoxins achieve complete and durable tumor regression in a myeloma mouse model

Amyloid plaques age oligodendrocyte precursors

A novel more relevant model of prostate cancer

LY-3343544, a MET-ADC with potent activity in cancer models

TR1801-ADC shows high efficacy in PDX models of solid tumors

IMGC-936 demonstrates promising antitumor activity in ADAM9-expressing cancer models

Aduro BioTech discovers cyclic GMP-AMP synthase inhibitors

FORMA Therapeutics presents CREB-binding protein and histone acetyltransferase p300 inhibitors

Celldex presents a novel tetravalent human anti-CD27/PD-L1 bispecific antibody, CDX-527

New serine-protein kinase ATM inhibitors identified at AstraZeneca

Jacobio-Alpha Pharmaceuticals, Beijing Jacobio Pharmaceuticals patent FGFR-4 inhibitors

Roche and Genentech disclose complement factor D inhibitors

TQB-3804 demonstrates promising antitumor activity in EGFR-mutant tumor models

Regeneron and Alnylam collaborate to discover, develop and commercialize RNAi therapeutics

Ascentage Pharma and Junshi Bioscience to evaluate the combination of APG-1387 and toripalimab

Diarylquinoline analogues of bedaquiline with improved anti-TB potency and lower cardiotoxicity

OJT-007 and OJT-008 characterized as inhibitors of M. tuberculosis MetAP

Phase II results for benralizumab in PDGFRA-negative hypereosinophilic syndrome

FDA approves Dovato for treatment-naive HIV-1

Topline data from Japanese TIMES 1 study of imeglimin in type 2 diabetes

Poxel reports phase Ia data for MPC inhibitor PXL-065

Phase I trial assesses iC9.GD2.CAR.IL-15 T cells in pediatric relapsed or refractory neuroblastoma

Lixte Biotechnology initiates phase Ib/II study of LB-100 in MDS

Frequency Therapeutics reports phase I/II data on FX-322 for hearing restoration

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