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BioWorld Science

July 22, 2019

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Knockout of presenilin-1 reduces T-cell acute lymphoblastic leukemia

EssexBio and Mitotech announce promising topline data from VISTA-1 phase III study

PIQUR announces treatment of first subject in first-in-human study of topical bimiralisib

Swedish MPA approves first-in-human trial of ILP-100

Mechanism of action exploration for the clinical-stage compound PRI-002

Discovery of novel P2X7R antagonists for the treatment of neurodegenerative disease

Biallelic variants in COX4I1 linked to a novel phenotype resembling Leigh syndrome

Guangzhou Maxinovel Pharmaceuticals patents PD-1/PD-L1 interaction inhibitors

New E3 ubiquitin-protein ligase Mdm2 inhibitors disclosed by Gan & Lee Pharmaceuticals

Asahi Kasei Pharma discovers prostanoid EP4 receptor agonists

Rpxds identifies dual FTO/COMT inhibitors

Inactivation of RBPJ leads to improper communication in brain pericytes and vascular malformations

GlaxoSmithKline patents receptor-interacting serine/threonine-protein kinase 1 inhibitors

CCR9 and OSM found to predict efficacy of PF-00547659 in patients with ulcerative colitis

At HIV Science meeting, lively discussion on what a cure will take

Biohaven receives complete response letter for Nurtec

China NMPA clears initiation of phase I bridging registrational study of Tibsovo

VISIBLE 2 trial of subcutaneous vedolizumab in Crohn's disease meets primary endpoint

Hypertrophic cardiomyopathy model shows potential of phosphomimetic-RLC gene therapy

Ascentage initiates phase Ib study in China with APG-1252 and osimertinib in NSCLC

U.S. approval for Otezla to treat oral ulcers associated with Behcet's disease

Hamlet reports outcome of phase I/II study of Alpha1H in bladder cancer

Tiziana reports preliminary topline data from phase IIa trial of milciclib in advanced HCC

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