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BioWorld Science

Aug. 12, 2019

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RHEB gene brain somatic mutation may cause focal cortical dysplasia type II

New antibody targets CAF-derived antigens in ovarian and pancreatic cancer

Phase I safety and immunogenicity data for GLS-5300 MERS vaccine

BI-2852 directly inhibits KRAS by binding to a pocket previously thought undruggable

Phase III results for fixed-dose combination of bempedoic acid plus ezetimibe

Children's Medical Center identifies new Rac-GTPase inhibitors

Array patents proto-oncogene tyrosine-protein kinase receptor Ret inhibitors

Brain diseases have shared superhighway vulnerabilities

PI3Kdelta inhibition may be useful in dementia

PCOS linked to interleukin-22 by way of microbiome

Ionis Pharmaceuticals describes oligonucleotides targeting human dynamin-2

New C5a-R antagonists identified at Idorsia Pharmaceuticals

GeneCentric enters second phase of academic-industry head and neck cancer partnership

Phase I study evaluates Fluzone and Flublok seasonal flu vaccines with two experimental adjuvants

AMPK-related kinases SIK1 and SIK3 identified as targets for non-small-cell lung cancer

Bristol-Myers Squibb initiates first-in-human study of BMS-986288

VenatoRx enrolling participants in phase III study of cefepime/VNRX-5133

Lysozyme inhibitors show promise for treating neuropathic pain

FDA clears IND application for first-in-human study of QR-1123

First patient enrolled in proof-of-concept trial of IMU-838 in primary sclerosing cholangitis