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BioWorld Science

Nov. 13, 2019

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Role of p300 in BRD4-NUT-driven NUT carcinomas and novel dual BET/p300 bromodomain inhibitors

MAb targeting TREM1+ myeloid cells boosts antitumor immunity and checkpoint inhibitor sensitivity

Prelude initiates phase I study of PRT-811 in advanced solid tumors, gliomas and myelofibrosis

Encouraging results seen in phase II studies of NanoPac paclitaxel

Corcept initiates phase II study of miricorilant for antipsychotic-induced weight gain

Small-molecule STING agonist promotes durable antitumor immunity causing complete tumor regression

Case study points to protective AD gene

RNA controls muscle stem cells

24-week data presented from HMM0301 phase III monotherapy study of dorzagliatin

FDA approves IND for WP-1066

FDA places on hold the phase I/II IGNITE DMD study of SGT-001

New data presented for ParvOryx in human ovarian cancer explants

DCC-3116 as a promising inhibitor of autophagy in preclinical models of RAS-mutant cancers

Preclinical and preliminary first-in-human data presented for STRO-002

Chugai Pharmaceuticals presents phase I data for EOS-789

SentiBio presents novel allogenic cell therapy, SENTI-101

KD-025 meets primary endpoint at interim analysis of pivotal ROCKstar study in chronic GvHD

Positive data presented from initial cohort of phase IIb study of ORMD-0801 in T2D

Virginia Tech Intellectual Properties describes mitochondrial uncouplers

Celgene patents compounds for diffuse large B-cell lymphoma

Macrocyclic oligopeptides identified at Roche

Vertex, Merck & Co. describe endoplasmic reticulum stress inducers

New P2X7 receptor antagonists identified at Shionogi

Break out the sparkling apple cider for DUR-928 alcoholic hepatitis data

New exploratory phase I/II study in Japan assesses NS-089 in Duchenne muscular dystrophy

Bellerophon reports initial data from acute hemodynamic study of INOpulse

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