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BioWorld Science

Feb. 28, 2020

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AI finds structurally unique antibiotics

New dihydroquinoxalinone analogues targeting tubulin with promising preclinical antitumor action

New receptor tyrosine kinase inhibitor acts as a broad-spectrum coronavirus inhibitor in vitro

Neuronal necrosis induced by YAP deprivation mostly occurs in early stages of Alzheimer's disease

FDA approves Nexlizet tablet as first non-statin LDL-C lowering combination medicine

Positive top-line results for phase III ALLIUM study of Exblifep for cUTI

Novel alphaVbetea6-targeted PDC shows promise in preclinical models of PDAC

Progranulin as a novel prognostic biomarker in community-acquired pneumonia

Phase I data for novel lentiviral vector therapy for children with Fanconi anemia

First patient enrolled in first-in-human study of NI-006

Dosing begins in phase I study of KAN-101 for the treatment of celiac disease

CD5.CAR/28zeta CAR T cells show antitumor activity in relapsed/refractory T-cell lymphoma

FDA approves IND and grants orphan drug status for HBM-9167

Boehringer Ingelheim Pharma patents KLKB1 inhibitors

Microglial fresh start helps heal brain trauma

Inflazome divulges new NLRP3 inflammasome inhibitors

Leo Pharma A/S presents RORC ligands

Amgen and Carmot Therapeutics identify USP30 inhibitors

Epizyme discloses new SETD2 inhibitors

DNA-PKcs inhibitor increases the antitumor activity of localized DNA-damaging therapies

S1PR1 is required for tumor vascular normalization, enhancing the efficiency of antitumor agents

Clene announces interim blinded data from phase II study of CNM-Au8 for vision impairment in MS

Spark Therapeutics opens enrollment in phase I/II study of SPK-3006 in late-onset Pompe disease

FDA approves Nurtec ODT for acute treatment of migraine

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