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BioWorld Science

June 19, 2020

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Discovering pharmacological enzyme activators

ShanghaiTech University presents new estrogen receptor protein regulators

Clinical activity seen with bomedemstat in phase II study in advanced myelofibrosis

Positive topline phase II data for XP-3924 in type 1 diabetes mellitus

SETD2 as biomarker of overall survival in systemic mastocytosis

Novel humanized immunocompetent mouse model to study DCP-001 vaccine

Mutations in GBF1 associated with hereditary motor neuropathy

Merck & Co. discovers adenosine receptor A2A and/or A2B antagonists

Nimbus Lakshmi identifies new TYK2 inhibitors

Bristol-Myers Squibb patents FPR1/FPR2 agonists

New androgen and/or glucocorticoid receptor antagonists synthesized at Nuvation Bio

Phase I data presented for PF-06882961 in patients with type 2 diabetes

New peripheral 5-HT2A antagonists for NAFLD treatment by structural modification of pimavanserin

Neutralizing MAb from a convalescent patient inhibits SARS-CoV-2 infection in preclinical models

ZSCAN12 gene linked to congenital lower urinary tract obstruction

Innovent begins phase Ib/II trial of IBI-362 in overweight or obese subjects in China

Reistone begins dosing in phase II study of SHR-0302 for alopecia areata

Parkinson's findings have implications for models, targets, publications

FDA approves Crysvita for tumor-induced osteomalacia

Durvalumab/tremelimumab immunotherapy effective with chemotherapy in biliary tract cancer

FDA grants accelerated approval to Tazverik for relapsed/refractory follicular lymphoma

Loss-of-function mutation in CCDC134 gene tied to severe osteogenesis imperfecta

Amgen begins phase III trial with AMG-510 for NSCLC with KRAS p. G12c mutation

FXR agonist TERN-101 enters phase IIa study for NASH

Clover's COVID-19 vaccine candidate enters first-in-human study

First-in-human study evaluates GT-103 in refractory advanced NSCLC

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