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BioWorld Science

Oct. 22, 2020

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A stinging defeat for infections

Researchers develop a new murine model of seizures with Chd8 haploinsufficiency

DUSP6 is implicated in vascular disease and may be a therapeutic target

Abpro completes dosing in phase I trial of ABP-300 for COVID-19

Optimization of selective antagonists of vasopressin V1A receptor derived from triazolobenzazepines

Hyaluronan is present in the alveolar spaces in lungs of patients with fatal COVID-19

SARS-CoV-2 RNA genome can be targeted using small-molecule binders and RIBOTAC degraders

Phase III study of masitinib in severe asthma uncontrolled by ICS meets primary endpoint

Oxeia initiates phase II study of OXE-103 for concussions

Storm Therapeutics patents METTL3 inhibitors

Centauri Therapeutics divulges new antibacterials

Array BioPharma presents new PTPN11 inhibitors

First patient enrolled in MERKLIN 2 trial of domatinostat plus avelumab in MCC

New CDK inhibitors presented by Aurigene Discovery Technologies

Sorrento Therapeutics patents CD38-targeting antibodies

Poseida and TScan collaborate to develop TCR-T cell therapies for treatment of COVID-19

Second part of daratumumab CASSIOPEIA study in multiple myeloma meets primary endpoint

First-in-human injection of [68]Ga-NT-20.3 found to be well-tolerated without AEs

Phase I data presented for RP-L201 in patients with LAD-I

Gene therapy approaches tackle multiple forms of blindness

FDA clears Cyclo to open global phase III trial of Trappsol Cyclo for NPC in U.S.

MAb 5D3-mertansine antibody-drug conjugate shows efficacy in prostate cancer mouse models

Ultimovacs reports 5-year OS data from phase I trial of UV-1 in NSCLC

Nanoform targets initiation of first-in-human trial of nanoformed piroxicam before year-end

Daiichi initiates phase I trial of DS-1055 in advanced or metastatic solid tumors