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BioWorld Science

Nov. 16, 2020

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3D spheroid cultures of primary human hepatocytes may improve the screening of CYP3A4 induction

Inhibition of the BDNF-TrkB pathway shows pain recession effect in a rat model

Zydus reports positive phase II data for PegiHep in patients with COVID-19 in India

First patient dosed in phase I study of BBP-398

University of North Carolina patents CAR compositions targeting carbonic anhydrase IX

RNA drugging strategies beyond oligos shaping up

Bayer, The Broad Institute identify new KAT6A and/or KAT6B inhibitors

Phase II data presented for SHR-1314 in patients with plaque psoriasis

Reversal of pumping direction is reversal of fortune for tumor cells

New alpha-protein kinase 1 activators discovered at Shanghai Yaoyuan Biotechnology

Heart development protein has role in adult immunity

Jiangsu Simcere Pharmaceutical R&D discloses new EGFR inhibitors

Positive data from two pooled post-hoc analyses of phase III ORION trials of inclisiran

New integrated stress response pathway modulators synthesized at Evotec International

CEA-Cupid/[211At]Psyche-B: a pretargeting system for radionuclide therapy of CEA-positive tumors

ObsEva reports topline phase IIa data on ebopiprant to treat preterm labor

First phase I data presented for retifanlimab in patients with advanced solid tumors

FDA complete response letter for sutimlimab cites third-party manufacturing issues

OSE Immunotherapeutics' agonist monoclonal antibody OSE-230 designed to resolve inflammation

Phase II CALAVI trials of Calquence in COVID-19 do not meet primary efficacy endpoint

Phase III study of mRNA-1273 for COVID-19 meets primary efficacy endpoint at interim analysis

FDA grants accelerated approval to Keytruda with chemotherapy for TNBC

Tonix reports preliminary nonhuman primate data on COVID-19 vaccine candidate TNX-1800

Vicore Pharma opens enrollment in phase II study of C-21 for IPF

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