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BioWorld Science

Nov. 3, 2021

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ADAM9 is a driver of disease severity in COVID-19 and a potential therapeutic target

LncRNA LINC00978 is a potential diagnostic marker of colorectal cancer

SAR-439883 rescues memory deficits and prevents neurodegeneration in animal models of AD

Targeting IRE1-mediated ER stress response and lipid reshuffling for reprogramming TME

PF-00835231 and its prodrug PF-07304814 show promising SARS-CoV-2 antiviral activity

Sanofi patents new YAP1/TEAD interaction inhibitors

Foghorn Therapeutics discloses new PROTACs

UCB identifies new IL-17 modulators

GB005 synthesizes BTK inhibitors

U.S. researchers patent new meayamycin derivatives

Mechanism of KRAS-G12C inhibitors unveiled: RGS3 enhances the GTPase activity of mutant and WT KRAS

KDM5B suppresses antitumor immunity by epigenetic silencing of retroelements in melanoma models

Detachable glucosylated PEG chains allow anti-PD-L1 antibody access to glioblastoma tumors

Low glycemic diets alter lipid availability and influence cancer cell metabolism to affect growth

FTD3-associated reactive astrocytes display autophagy impairments and cause neuronal toxicity

Angelman syndrome gene therapy restores dual-isoform expression of UBE3A in the developing brain

Structure-based optimization identifies potent galactokinase inhibitors

New treatment targets identified in opiate abstinence

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