BioWorld Science

Nov. 25, 2021

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CDX-585, a novel bispecific antibody targeting ILT4 and PD-1 for cancer treatment

Adenosine A1R/A3R agonist AST-004 ameliorates brain infarction in an NHP model of stroke

Pfizer describes new MAP4K1 inhibitors

New Bcl-2 inhibitors discovered at Prelude Therapeutics

IL-17A/IL-17RA interaction modulators patented by Janssen Pharmaceutica

New PADI4 inhibitors synthesized at Gilead

Meiji Seika Pharma divulges histamine H4 receptor antagonists

Discovery of KSQ-004, a Regnase-1/SOCS1 dual-edited human CRISPR/Cas9-engineered TIL therapy

Anti-CLDN18.2 BiME ES-028 shows promise as cancer immunotherapeutic

Probiotic strategy prevents Enterococcus escape from the gut

"I was not always someone who would have advertised probiotics," Michael Otto told BioWorld Science. And it's easy to see why. At this point, probiotics are more often dubious wellness offerings than evidence-based therapeutics. Read More

XIAP deficiency is associated with susceptibility to microbial triggers of intestinal inflammation

PCC-0105002 attenuates neuropathic pain without motor coordination-associated side effects

Restoration of NXTAR as a novel approach for prostate cancer treatment with enzalutamide

Liver-humanized mice developed as more accurate model of human cardiometabolic diseases

Today's news in brief

BioWorld

BioWorld briefs for April 24, 2026.

A free gene therapy? Regeneron’s Otarmeni approved for hearing loss

BioWorld

Children and adults with a type of congenital hearing loss now have a free treatment option, with the U.S. FDA’s accelerated approval of Regeneron Pharmaceuticals...

Detecting the invisible: minimal residual disease at AACR 2026

BioWorld Science

Minimal residual disease (MRD) has become a central concept in modern oncology, reshaping how clinicians evaluate response, relapse risk and treatment precision....

At AACR: Epigenetic fingerprints in metastases track tumor origin

BioWorld

When a tumor migrates and colonizes another tissue or organ, it can be identified as a metastasis, but its origin is not always clear. Now, a study based on...

Illustration of human face that looks abstract and digital

AACR 2026: The age of agentic AI in oncology

BioWorld Science

New Approach Methodologies (NAMs) for drug development are transforming biomedical research by replacing or complementing animal models. More than 90% of...