Researchers from University of Miami Miller School of Medicine reported preclinical data for ZyVersa Therapeutics' novel humanized IgG4 monoclonal antibody targeting apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), named IC-100. Read More
A University of Texas MD Anderson Cancer Center-based research team demonstrated that Col1 produced by pancreatic cancer cells is an oncogenic homotrimer variant (a1/a1/a1) instead of the normal Col1 heterotrimer (a1/a2/a1) produced by fibroblasts. Read More
GlaxoSmithKline has divulged mas-related G protein-coupled receptor member X2 (MRGPRX2) antagonists reported to be useful for the treatment of osteoarthritis, migraine, asthma, irritable bowel syndrome, atopic dermatitis, psoriasis, urticaria and rheumatoid arthritis, among other disorders. Read More
The National Institute of Pharmaceutical R&D (Beijing) has described bridged heterocyclyl-substituted pyrimidine compounds acting as tyrosine-protein kinase JAK-1 and/or non-receptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of inflammation, autoimmune disease and cancer. Read More
Monte Rosa Therapeutics has synthesized new proteolysis targeting chimera (PROTAC) compounds comprising a protein cereblon (CRBN) binding moiety covalently linked to a eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)-targeting moiety reported to be useful for the treatment of cancer. Read More
Chengdu Baiyu Pharmaceutical has presented pyrimidine derivatives acting as GTPase KRAS (Gly12Cys mutant) inhibitors reported to be useful for the treatment of cancer. Read More
Beckley Psytech has divulged ergoline analogues acting as 5-HT2A and/or 5-HT2B and/or 5-HT2C receptor agonists reported to be useful for the treatment of depression. Read More
Investigators presented the development of a novel orthotopic xenograft mouse model to study the role of cancer-associated fibroblasts (CAFs) in tumor lymphangiogenesis and regional lymph node metastasis in lung cancer. Read More
Researchers at the Genome Institute of Singapore and affiliated organizations published results from a study that aimed to better understand the causes of pediatric syndrome with liver cirrhosis. Read More
NanoViricides has outlined plans to develop NV-387-T for monkeypox virus. NV-387-T is made by encapsulating tecovirimat within NV-387 polymeric micelles. Read More
Researchers around the world are making advances in understanding how HIV becomes latent and seeking out vulnerabilities that could provide routes to targeting reservoirs and eliminating them. The virus persists in some cells after infection despite antiretroviral therapy (ART) and these contain inactive proviruses that can replicate and trigger the disease. Read More
SELLAS Life Sciences has announced results from preclinical in vitro studies for its highly selective CDK9 inhibitor, GFH-009, in solid cancer and acute myeloid leukemia (AML) cell lines. Read More
Mount Sinai is leading a team of researchers that has been awarded a 3-year, USD 500,000 grant from Stand Up To Cancer (SU2C) to explore therapeutic approaches to lung tumors with mutations in the KRAS gene. Read More
Shionogi has reported that S-217622 (ensitrelvir fumaric acid), the company's orally administered antiviral drug for COVID-19, shows high in vitro antiviral activity against the SARS-CoV-2 Omicron subvariant BA.2.75. Read More
Tetra Bio-Pharma has announced new promising preclinical results with ARDS-003 (onternabez) from live SARS-CoV-2 virus infection studies, as well as a septic lung model, carried out by independent researchers. Read More
