Secretion of gastric acid is tightly controlled by the neuroendocrine system of the stomach, formed by an interconnected network of nerves and different hormone-producing cell types, particularly G cells that release the hormone gastrin. Read More
Tarsier Pharma is developing the small molecule TRS as an anti-inflammatory treatment for retinal diseases, with the eye drop formulation TRS-01 in phase III development for noninfectious anterior uveitis and uveitic glaucoma. Read More
Scientists from the University Grenoble Alpes in France and colleagues have recently identified a promising drug candidate with broad-spectrum activity against apicomplexans using a drug repurposing strategy. Read More
Live bacterial therapeutics (LBTs) that engraft in the gut and provide persistent beneficial functions to the host have emerged as a promising strategy against a wide range of diseases. Read More
Allorion Therapeutics has divulged imidazolopyridazines or pyrazolopyrimidines acting as nonreceptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of psoriasis, psoriatic arthritis, ulcerative colitis, Crohn's disease and systemic lupus erythematosus. Read More
Metabrain Research and Shanghai Visonpharma have presented macrocyclic Toll-like receptor 7 (TLR7) agonists reported to be useful for the treatment of hepatitis B virus (HBV), HCV, HIV and influenza virus infections, and cancer. Read More
MagicMed Industries has divulged new prenylated psilocybin derivatives acting as 5-HT2A and/or 5-HT1A receptor modulators reported to be useful for the treatment of psychiatric disorders. Read More
Medshine Discovery has disclosed pyrazolopyrazine-linked tricyclic compounds acting as tyrosine-protein phosphatase non-receptor type 11 (PTPN11) inhibitors reported to be useful for the treatment of cancer. Read More
Jingrui Biopharma has described bromodomain and extra-terminal (BET) inhibitors, particularly bromodomain-containing protein 4 (BD1 domain) (Brd4 BD1) inhibitors, reported to be useful for the treatment of cancer. Read More
International AIDS Vaccine Initiative (IAVI) and Merck & Co. scientists have developed a SARS-CoV-2 vaccine using the vesicular stomatitis virus (VSV) chimeric virus approach, wherein VSV was modified by substituting the VSV G surface glycoprotein gene with a coding sequence for the SARS-CoV-2 spike (S) glycoprotein. Read More
During pregnancy, the female body experiments multiple physiological changes that require modulation of the neuroendocrine system, mainly being contributed by the hormone prolactin and its regulation by the hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons. Read More
Saniona has announced its program to develop small molecules targeting Kv7 ion channels to treat epilepsy has made sufficient progress to move into lead optimization. Read More
