Chemokines are small signaling cytokines that are involved in many physiological processes such as host immune responses, wound healing and bone remodeling, with two of these chemokines, C-X-C motif chemokine 9 (CXCL9) and CXCL10, being involved in different osteoimmuno-modulating pathways. Read More
Baylor College of Medicine has disclosed bromodomain testis-specific protein (BD2 domain) (BRDT-BD2) inhibitors reported to be useful for the treatment of male contraception and male infertility. Read More
Viking Therapeutics has divulged dual agonists of GLP-1 and glucose-dependent insulinotropic receptor (GDIR) reported to be useful for the treatment of nonalcoholic fatty liver disease (NAFLD). Read More
Earth Chemical has patented lipoprotein lipase (LPL) activators reported to be useful for the treatment of hypertriglyceridemia. An exemplified compound rescued LPL from N-terminal GST-tagged angiopoietin-like 4 (ANGPTL4)-induced inactivation (EC50 = 1.01 mcM) in fluorescence-based assays. Read More
Biofront Therapeutics has identified fMet-Leu-Phe receptor (fMLP; FPR1) antagonists reported to be useful for the treatment of glioblastoma, traumatic brain injury and stroke. Read More
Working to overcome the short circulatory half-lives of platinum drugs in vivo, researchers at Shenzhen University and the City University of Hong Kong have explored the use of a platinum(IV) prodrug to bind erythrocytes. Read More
A fusion protein removed beta-amyloid plaque without producing the neurotoxic inflammation associated with other treatments, such as aducanumab immunotherapy. It is based on the alphaA Beta-Gas6 fusion protein developed in a mouse model of Alzheimer's disease (AD) by a team of researchers at The Korea Advanced Institute of Science and Technology (KAIST) in South Korea. Read More
Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a cytoplasmic protein that controls signal transduction from different receptor families, and plays a key role in regulating immunity. Read More
To develop a safe and effective respiratory syncytial virus (RSV) vaccine for use in early life, Boston Children's Hospital scientists and their collaborators developed CAF-08, a liposomal formulation consisting of combined TLR7 (3M-052) and Mincle (trehalose-6,6-dibehenate [TDB]) agonists and the RSV pre-F antigen. Read More
Listeria monocytogenes causes sporadic outbreaks of infection globally through contaminated food and is fatal in immunocompromised individuals. Read More
