Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestinal tract that often causes the development of colorectal cancer (CRC). Read More

Griffith University has presented new compounds reported to be useful for the treatment of respiratory syncytial virus (RSV), influenza A, influenza B, influenza C and parainfluenza virus infections. Read More

Suzhou Kowloon Hospital Shanghai Jiao Tong University School of Medicine has divulged new Toll-like receptor 7 (TLR-7) agonists reported to be useful for the treatment of cancer and viral infections. Read More

XtalPi has discovered heterocyclic amide derivatives acting as prostaglandin E2 receptor EP4 subtype (PTGER4; EP4) antagonists reported to be useful for the treatment of pain, rheumatoid arthritis, osteoarthritis and cancer. Read More

China Hinye Pharmaceutical has presented new phenol derivatives acting as GABA(A) receptor alpha1beta2gamma2S positive allosteric modulators (PAMs) reported to be useful for the treatment of anxiety disorders, convulsions, migraine, nausea and vomiting and neurodegeneration. Read More

Medshine Discovery has patented pyrimidopyran-containing compounds acting as GTPase KRAS (G12D mutant) inhibitors reported to be useful for the treatment of cancer. Read More

The usefulness of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCHL1) for the early prediction of long-term traumatic brain injury (TBI) outcomes has not been well investigated. Read More

A factor involved in the apoptosis cascade, caspase-6, has been identified as a target for interfering with the replication of coronaviruses in work by The University of Hong Kong scientists and their collaborators. Read More

A proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF) are two ligands of the tumor necrosis factor (TNF) superfamily with a crucial regulatory role in B-cell maturation and differentiation. APRIL and BAFF action occurs through binding to three TNF receptors: TACI (transmembrane activator and Ca2+ modulator interactor), B-cell maturation antigen (BCMA), and BAFF receptor (BAFF-R) with different affinities. Read More

Ferroptosis, a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, is limited in some tumors. Scientists have identified a glutathione (GSH)-independent axis centered mainly on the ferroptosis suppressor protein 1 (FSP1) as responsible for this suppression. Read More

Hansoh Pharmaceutical's Hansoh (Shanghai) Healthtech subsidiary has entered into an exclusive licensing and codevelopment agreement with the Global Health Drug Discovery Institute (GHDDI; Beijing Huayi Health Drug Discovery Institute) for exclusive worldwide rights to develop, manufacture and commercialize GDI-4405, an oral small-molecule SARS-CoV-2 3CL protease inhibitor. Read More

Turn Biotechnologies is advancing its development of preclinical ophthalmic therapeutic products, notably TRN-004, a tailored protein cocktail to rejuvenate targeted cells in the eye. Read More

Preterm birth is the leading cause of death in children under 5 and those who survive commonly suffer from life-long deleterious health impairments. Preterm labor (PTL) is defined as sustained contractions prior to 37 weeks of gestation, which occurs in about 10% of all pregnancies in the U.S. The mechanisms that initiate PTL are still not well understood; researchers aimed for the identification of molecular targets for PTL. Read More

Treating mice with butyrate, a short-chain fatty acid that is normally produced by beneficial gut microbes, prevented anaphylactic shock in allergic mice when they were exposed to peanuts after treatment. It also reduced inflammation in animals with colitis. Read More