PharminoGen has presented prazole-carboxamide derivatives acting as cannabinoid CB1 receptor antagonists reported to be useful for the treatment of non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease, dyslipidemia and diabetes. Read More
Korea Research Institute of Chemical Technology (KRICT) and PINOTBIO have patented benzothiazole and benzimidazole derivatives acting as NAD-dependent protein deacetylase sirtuin-7 (SIRT7) inhibitors reported to be useful for the treatment of cancer, among other disorders. Read More
Prazertherapeutics has discovered MAPK p38 and nitric oxide (NO) production inhibitors reported to be useful for the treatment of inflammation. Read More
The Universite Catholique de Louvain has described polypeptides acting as lactate dehydrogenase (LDH) tetramerization inhibitors reported to be useful for the treatment of cancer. Read More
At the ongoing American Chemical Society meeting, Genentech detailed the discovery of KRAS G12C-selective covalent inhibitors for the potential treatment of cancer. Read More
Shandong University scientists have evaluated structural modification of parbendazole to derive potential treatments for head and neck squamous cell carcinoma (HNSCC). Read More
Seelos Therapeutics has been selected to receive a grant from The Michael J. Fox Foundation (MJFF) for Parkinson's Research to advance preclinical research and development of its gene therapy delivered SLS-004 program. Read More
Trigeminal neuralgia is a debilitating chronic neuropathy characterized by sudden, short and intense episodes of shooting, stabbing or shock-like pain in the face. To date, there is still an incomplete understanding of the pathophysiologic molecular mechanisms behind trigeminal neuralgia and the search for molecular targets is of medical need. Read More
