Carrying the apolipoprotein E4 allele (APOE4), and not the APOE3 variant, is the strongest risk factor for developing Alzheimer’s disease (AD). But the underlying mechanism has remained elusive. Now, researchers at MIT and Mount Sinai have found that in brains carrying the APOE4 allele, lipid and cholesterol processes were dysregulated in oligodendrocytes and that this effect reduced myelination. Read More
Elpiscience Biopharma Ltd.’s ES-005 is a new high-affinity monoclonal antibody (MAb) that blocks human lymphocyte-activated gene 3 (LAG3) from binding to several ligands, such as major histocompatibility complex class II (MHC-II), liver and lymph node sinusoidal endothelial cell C-type lectin (L SECtin) and fibrinogen like 1 (FGL1). Read More
At the recent Society for Immunotherapy of Cancer meeting, researchers from Dong-A ST Co. Ltd. presented preclinical data for the novel small-molecule general control nonderepressible 2 (GCN2) inhibitor, DA-4507, being developed for the treatment of cancer. Read More
Circulating tumor cells (CTCs) transit through the bloodstream and they exhibit heterogeneity in their expression of epithelial and mesenchymal marker proteins, including the cadherin proteins. Based on these findings, researchers from Massachusetts General Hospital and Harvard Medical School evaluated the potential of the dual anti-cadherin antibody, 23C6, in targeting CTC-dependent blood-borne metastasis. Read More
Bonum Therapeutics Inc., a spinout of Good Therapeutics Inc., which Roche Holding AG acquired in August, has announced a US$93 million series A financing. Bonum is developing new therapies based on the proprietary platform of allosterically regulated, conditionally active therapeutics developed by Good Therapeutics. The core platform makes possible the engineering and development of a wide range of medicines. Read More
AZD-4820 was evaluated in a cell viability assay performed in 30 human cancer cell lines, defining 12 different types of cancer, and testing a dose-range of multiplicity of infection (MOI); potent oncolytic activity was observed with EC50 values of <0.1 MOI in nearly all of the tested cells. Read More
Rhabdomyosarcoma (RMS) occurs in 3% of all pediatric cancers. Aberrant Hedgehog (Hh) activation can be ligand-dependent or -independent, but current clinical Hh inhibitors targeting SMO are effective only for ligand-independent tumors. Researchers at Vall d’Hebron Institut de Recerca, Barcelona, Spain, developed a targeted therapeutic for Hh ligand-dependent tumors. Read More
The FDA has awarded orphan drug designation to Canbridge Pharmaceuticals Inc.'s CAN-106, a clinical-stage long-acting recombinant humanized monoclonal antibody targeting C5, for the treatment of myasthenia gravis. Read More
Collplant Biotechnologies Ltd. and Ramot at Tel Aviv University Ltd., the technology transfer company of Tel Aviv University and Sheba Medical Center, have entered into a license and research agreement to codevelop a gut-on-a-chip tissue model for drug discovery and high-throughput screening of drugs. Read More
Leitat Technological Center has patented 1H-pyrazole derivatives acting as sigma nonopioid intracellular receptor 1 (SIGMAR1) and/or sigma intracellular receptor 2 (TMEM97) ligands reported to be useful for the treatment of pain and neurological disorders. Read More
Chemocentryx Inc. has divulged azetidinyl-acetamides acting as atypical chemokine receptor 3 (ACKR3) antagonists reported to be useful for the treatment of cancer and inflammatory disorders. Read More
Researchers from Rigel Pharmaceuticals Inc. have reported the discovery of indirect activators of AMPK as potential candidates for the treatment of type 2 diabetes. Read More
Novartis AG has described 3C-like proteinase (3CLpro) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19). Read More
Integral Biosciences Pvt. Ltd. (IBS) has synthesized oxysterols receptor LXR-β (LXRB) agonists reported to be useful for the treatment of cancer, inflammation and Alzheimer's disease. Read More
Elevatebio LLC and Affini-T Therapeutics Inc. have entered into a partnership to advance Affini-T's engineered T-cell therapies focused on KRAS, an oncogenic driver mutation in solid tumor cancers. Read More
Heptares Therapeutics Ltd. has presented G protein-coupled receptor GPR35 agonists reported to be useful for the treatment of acute and chronic pain, gastrointestinal and lung diseases. Read More
New and updated preclinical data presented at the Society for Immunotherapy of Cancer's 37th Annual Meeting in Boston, by:
GI Cell, Maia Biotechnology. Read More
