Research led by Indiana University School of Medicine and the University of Notre Dame shows a new treatment for peanut allergy is effective in a mouse model. The therapy, a covalent heterobivalent inhibitor (cHBI), differs from most allergy treatments in that it is more of a preventative therapy rather than a drug to treat immediate acute symptoms. Read More
Two papers in the Feb. 8, 2023, issue of Cell Host & Microbe have reported new insights into the relationship between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and alterations in the gut microbiome, and how those relationships change over time. A reliable way to diagnose ME/CFS would be a huge step forward for the study of ME/CFS. Currently, the condition is diagnosed purely by symptoms, which are assessed via questionnaire. Read More
Previous research has demonstrated that overexpression or gain-of-function mutations of enhancer of zeste homolog 2 (EZH2) are significantly associated with tumor cell proliferation of a number of cancers. Read More
Spinal-bulbar muscular atrophy (SBMA), also called Kennedy disease, is an X-linked genetic disorder in which the loss of motor neurons affects the parts of the nervous system that control voluntary muscle movement. Read More
Researchers from Yale School of Medicine, along with Helsinki University Hospital and University of Helsinki, have reported data from a study that aimed to assess the effects of a common variant in hydroxysteroid 17-β dehydrogenase 13 (HSD17B13 rs72613567-A) in the liver. Read More
Denali Therapeutics Inc. has disclosed NLRP3 inflammasome inhibitors reported to be useful for the treatment of stroke, gout, multiple sclerosis, Alzheimer's disease, hypertension, silicosis, graft-versus-host disease and nonalcoholic steatohepatitis (NASH). Read More
Sichuan Haisco Pharmaceutical Co. Ltd. has synthesized selective estrogen receptor degradation inducers (SERDs) reported to be useful for the treatment of cancer. Read More
Evaxion Biotech A/S and Pantherna Therapeutics GmbH have announced preclinical proof of concept for the combination of the two companies' key technologies. Read More
Aphiotx Inc. has identified sulfamoyl benzene derivatives acting as pannexin-1 (PANX1; MRS1) inhibitors reported to be useful for the treatment of opioid withdrawal. Read More
Japan's National Center for Global Health and Medicine (NCGM) has divulged 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of SARS-CoV-2 infections (COVID-19). Read More
Obesity is an important cause of death worldwide, and it is defined as a body mass index >30 kg/m2. Genome-wide association studies have been successful at identifying genomic loci tied to obesity. Read More
Fox Chase Chemical Diversity Center Inc. has described novel bis-amide containing compounds reported to be useful for the treatment of fungal infections. Read More
Additional early-stage research and drug discovery news in brief, from: Enzolytics, Evaxion Biotech, Hoth Therapeutics, Lineage Cell Therapeutics, Lixte Biotechnology Holdings, Pantherna Therapeutics. Read More
