Base editing (BE), a technique that modifies a single nucleotide in living cells, has been successfully tested to resolve the CD3δ mutation in severe combined immunodeficiencies (SCIDs) and produce functional T cells. For now, scientists at the University of California, Los Angeles (UCLA), completed the study on patient stem cells and artificial thymic organoids, shortening the way for future clinical trials. Read More
Restoring levels of the immune modulator mesencephalic astrocyte-derived neurotrophic factor (MANF) in the muscles of aged animals improved their regenerative capacity by promoting repair-associated injury responses, researchers from the University of Lisbon have discovered. Read More
Researchers from the National Institutes of Health recently presented preclinical data for the dopamine D3 receptor antagonist VK-4-116, which has potential for the treatment of opioid use disorder (OUD). Read More
Research at Artica Therapeutics BV has led to the development of C-C chemokine receptor type 2 (CCR2B) antagonists reported to be useful for the treatment of cancer. Read More
New research has shed light on a molecular mechanism that fuels inflammation in acute lung injury (ALI), a severe and often fatal condition. Macrophage necroptosis, a form of cell death, is a necessary process contributing to intrapulmonary inflammation during ALI. However, the molecular mechanism that initiates macrophage necroptosis has remained unclear until now. Read More
Breast cancer (BC) is a prevalent form of cancer among women globally. Recent studies suggest that circular RNA (circRNA) plays a significant role in BC progression, but the biological functions and underlying mechanisms remain unexplored. According to a recent study published in the Journal of Translational Medicine, the interaction between circDNAJC11 and TATA-box-binding protein-associated factor 15 (TAF15) promotes BC progression through the upregulation of MAPK6 expression and activation of the MAPK signaling pathway. Read More
Researchers from Centre National de la Recherche Scientifique, Inserm, Institut Curie and Uniwersytet im Adama Mickiewicza have prepared nitrogen-containing salinomycin derivatives reported to be useful for the treatment of cancer. Read More
Wigen Biomedicine Technology (Shanghai) Co. Ltd. has described 5-fluoro-7h-pyrrolo[2,3-d] pyrimidine compounds as Wee1-like protein kinase (Wee1) inhibitors potentially useful for the treatment of cancer. Read More
