Researchers have gained new insights into physiological mechanisms that protect against blood clotting in immobilized individuals by studying animals that stay immobile for a good chunk of the year at a time: hibernating bears. “As a clinician, if you think about immobility, you always think about thrombosis,” Tobias Petzold told BioWorld. But his team’s work, which was published in the April 13, 2023, issue of Science, demonstrated that “immobility can trigger antithrombotic mechanisms.” Read More
Researchers at Cold Spring Harbor Laboratory have successfully reversed epigenetic changes and slowed tumor growth in mouse models of diffuse intrinsic pontine glioma (DIPG) using antisense oligonucleotide (ASO) technology. DIPG is a rare pediatric brain cancer where the tumor’s location in the pons of the brainstem makes surgery impossible, and fractioned radiotherapy and chemotherapy efforts have failed to improve survival so far. Read More
Researchers from University of Belgrade, St. Jude Children’s Research Hospital and affiliated organizations have provided details on the discovery of novel orally bioavailable BET inhibitors as potential anticancer drug candidates. Read More
Bone development is a continuous process, but in some cases, soft tissues can mineralize due to some anomalies in repairing processes, thus leading to heterotopic ossification (HO). Max Planck Institute for Molecular Genetics researchers aimed to find the genetic causes tied to this abnormal bone-formation disorder. Read More
Pyramid Biosciences Inc. and Genequantum Healthcare (Suzhou) Co. Ltd. have entered into an exclusive license agreement to develop and commercialize GQ-1010, a potential best-in-class antibody-drug conjugate (ADC) targeting trophoblast cell surface antigen 2 (TROP2), worldwide except for Greater China (mainland China, Hong Kong, Macau, and Taiwan). Read More
The Wisconsin Alumni Research Foundation (WARF) and Ginkgo Bioworks Inc. have announced a partnership to leverage Ginkgo's proprietary high-throughput combinatorial chimeric antigen receptor (CAR) discovery and screening platform with the aim of discovering next-generation GD2 CAR T-cell therapies. Read More
It is known that in melanoma, transformed melanocytic cells acquire stem cell-like features; these cells have multilineage differentiation potential, thus allowing them to morph into cell states with neural crest cell (NCC)-like, epithelial-to-mesenchymal transition-like features, promoting its metastatic potential. Read More
Research at Incyte Corp. has led to the development of hetero-tricyclic compounds acting as GTPase KRAS (mutant) inhibitors and thus reported to be useful for the treatment of cancer, inflammatory and immunological disorders. Read More
Bracco Imaging SpA and Sonothera Inc. have entered into an agreement under which Bracco Imaging will provide its cutting-edge gas-filled microbubbles technology platform to Sonothera for use in the development of its novel, ultrasound-guided nonviral gene therapy platform. Read More
Mutations in fms-related receptor tyrosine kinase 3 (FLT3) are related to the increase of reactive oxygen species (ROS) in acute myeloid leukemia (AML). Recent studies suggest that by regulating ROS production and antioxidant expression, oncogenes such as FLT3 directly influence leukemia progression, even during anticancer therapy. Read More
Benzimidazole carboxylic acids acting as glucagon-like peptide 1 receptor (GLP-1R) agonists have been reported in a Terns Pharmaceuticals Inc. patent as potentially useful for the treatment of diabetes, obesity and liver diseases. Read More
Researchers from High Point University recently reported the discovery and preclinical evaluation of a novel class of highly selective dopamine D4 receptor-selective ligands as potential therapeutic candidates for substance use disorders. Read More
Bone remodeling involves a process of continuously cycling bone formation by osteoblasts balanced by resorption by osteoclasts. Development of osteoclast cells is initiated by RANKL and macrophage colony-stimulating factor (M-CSF) ligands leading to differentiation of bone marrow-derived monocytes (BMDMs) to generate osteoclast specified cells expressing TRAP, CTSK and MMP9. Read More
Esophageal squamous cell carcinoma (ESCC) is a common malignant subtype of esophageal cancer that predominantly occurs in East Asian countries. Although genomic aberrations and highly mutated genes, such as TP53, have been identified in advanced stages, the first occurrence of mutations and their related effects during ESCC carcinogenesis remain poorly understood. Read More
Zeno Management Inc. researchers have prepared and tested azole compounds described as transcriptional enhancer factor (TEAD) inhibitors potentially useful for the treatment of autoimmune diseases, inflammation and cancer. Read More
Merck Sharp & Dohme Corp. have identified nicotinic α7 receptor positive allosteric modulators reported to be useful for the treatment of Alzheimer’s and Parkinson’s diseases, and schizophrenia. Read More
