Implanting brain organoids into the brains of mice may allow the more realistic study of microglial cells during both healthy and disease states. This is what researchers from the Salk Institute and their collaborators found in a study published on May 11, 2023, in Cell. Read More
Researchers have compared the cellular responses driving allergic asthma to those in individuals with allergic rhinitis and conjunctivitis but no allergic response in the lungs. Asthma is “an umbrella term,” Josalyn Cho told BioWorld. But under that umbrella, the largest group of people are those whose asthma begins in childhood. And “those folks almost exclusively develop their asthma after they develop allergies.” Read More
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Sensitized nociceptors, such as during inflammation, respond to non-noxious stimuli. The precise molecular mechanisms for sensitization to mechanical stimuli are not well defined. Recent findings have suggested piezo-type mechanosensitive ion channel component 2 (Piezo2) to be part of these mechanisms. Read More
Gluetacs Therapeutics (Shanghai) Co. Ltd. has synthesized compounds targeting protein cereblon (CRBN) and their PROTACs (proteolysis targeting chimeras) reported to be useful for the treatment of cancer, anemia, transplant rejection, neurodegeneration, infections, autoimmune, inflammatory and metabolic disorders, among others. Read More
N-Methyl-D-aspartate (NMDA) receptors are essential components of the glutamatergic pathways in the central nervous system. NMDA receptors comprise two GluN1 subunits and two GluN2 subunits. Of the latter, the GluN2B subunit is involved in synapse development and plasticity, and cognitive function. Read More
Dana-Farber Cancer Institute Inc. has divulged proteolysis targeting chimeras (PROTACs) comprising a cereblon (CRBN) binding moiety covalently linked to a histone-lysine N-methyltransferase, H3 lysine-79 specific (DOT1L) targeting moiety via linker reported to be useful for the treatment of cancer. Read More
Haisco Pharmaceutical Group Co. Ltd. has described proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase cereblon binding moiety covalently coupled to poly(ADP-ribose) polymerase 1 (PARP-1; ARTD1) targeting moiety through a linker acting as PARP-1 degradation inducers reported to be useful for the treatment of cancer. Read More
Researchers from Sun Yat-Sen Memorial Hospital and affiliated organizations published data from a study that aimed to explore the mechanism of prostate cancer (PCa) metastasis to discover an intrinsic biomarker for metastatic PCa (mPCa). Read More
