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Home » Newsletters » BioWorld Science

BioWorld Science

Aug. 23, 2023

View Archived Issues
Clovibactin art concept

Cage fight could make for resistance-resistant antibiotic

A newly discovered antibiotic has been shown to block the synthesis of bacterial cell walls via immutable targets, raising the prospect of a class of drugs that will not lose effect through the development of antimicrobial resistance. Clovibactin, isolated from soil bacteria, targets the cell wall precursor molecules lipid II, lipid III and undecaprenyl phosphate (C55PP), all of which have a pyrophosphate group in common. Read More
stem-cells

Stem cell study functionally links Alzheimer’s risk genes

Investigators have functionally linked the Alzheimer’s disease (AD) risk gene SORL1 to apolipoprotein E (ApoE) and clusterin, another apolipoprotein. The work, Tracy Young-Pearse told BioWorld, is part of an attempt to “try to understand different subtypes of Alzheimer’s disease.” It maps some of what Young-Pearse termed the “many molecular roads that lead to Alzheimer’s” – which, in turn, is the first step to setting up roadblocks. Young-Pearse is an associate professor in the Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital and Harvard Medical School and co-leader of the Harvard Stem Cell Institute’s Nervous System Diseases Program. She is also the senior author of the paper describing the findings, which appeared online in Cell Reports on Aug. 22, 2023. Read More
Scanning electron micrograph of Lassa virus budding off a cell.

huMAb combination broadly protects primates against most LASV strains after viral exposure

Most of the West African population is at risk of infection with Lassa virus (LASV), which leads to Lassa fever that causes thousands of deaths every... Read More
Brain and encephalography

NS-041, a novel KCNQ2/3 activator for the treatment of epilepsy, presented at ACS meeting

Voltage-gated potassium channels (KCNQ) control neural excitability and their dysfunction leads to neuronal channelopathies frequently related to... Read More

Chengdu Kanghong Pharmaceutical patents new Nav1.8 blockers

Chengdu Kanghong Pharmaceutical Co. Ltd. has disclosed sodium channel protein type 10 subunit alpha (Nav1.8) channel blockers reported to be... Read More
A microscopic image of liver tissue affected by nonalcoholic fatty liver disease.

Thiophene derivatives acting as Cisd2 activators may prevent NAFLD development and progression

The CDGSH iron sulfur domain 2 (Cisd2) is a zinc finger protein that regulates endoplasmic reticulum Ca2+ uptake, maintains intracellular... Read More

Vincerx's antibody-drug conjugate VIP-943 receives FDA clearance for phase I study in AML

Vincerx Pharma Inc. has received IND clearance from the FDA to initiate a phase I trial for VIP-943, an antibody-drug conjugate (ADC) for acute... Read More
Illustration demonstrating muscle contraction in amyotrophic lateral sclerosis.

Akava announces IND clearance for AKV-9 to enter clinic for ALS

Akava Therapeutics Inc. has announced FDA clearance of its IND application for AKV-9 (formerly NU-9) for the treatment of amyotrophic lateral sclerosis (ALS). The company is planning a first-in-human phase I study in healthy subjects. Read More

Wigen Biomedicine Technology divulges new PARP inhibitors

Wigen Biomedicine Technology (Shanghai) Co. Ltd. has synthesized compounds acting as poly(ADP-ribose) polymerase (PARP; ARTD) inhibitors, preferably PARP-1, reported to be useful for the treatment of cancer. Read More

Shandong New Time Pharmaceutical describes new cathepsin K inhibitors for osteoporosis

Shandong New Time Pharmaceutical Co. Ltd. has identified cathepsin K inhibitors reported to be useful for the treatment of osteoporosis, among others. Read More
HIV drugs

NIAID grant supports development of ultra-long-acting HIV integrase inhibitor XVIR-110

Exavir Therapeutics Inc. has received a US$3 million award from the National Institute of Allergy and Infectious Diseases (NIAID), a division of the National Institutes of Health, to support the development of XVIR-110. Read More

Medshine Discovery presents new GTPase KRAS mutant inhibitors for cancer

Medshine Discovery Inc. has divulged GTPase KRAS (G12D mutant) inhibitors reported to be useful for the treatment of cancer. Read More

Preclinical characterization of novel TS inhibitor DG-1 presented

Thymidylate synthase (TS) is an enzyme essential for DNA synthesis and cell proliferation and is a potential oncoprotein itself. Consequently, TS is considered a molecular target for malignant tumors. Read More
CAR T cells attacking cancer cell

Verismo licenses anti-CD19 binders to support Synkir-310 KIR-CAR T-cell therapeutic

Verismo Therapeutics Inc. has entered into a licensing agreement with the University of Pennsylvania for worldwide exclusive rights for two newly discovered anti-CD19 binders, the result of a sponsored research agreement between the two parties. Read More

Beijing Entaiwei Medicine Science Technology discovers new prodrugs of β-D-N4-hydroxycytidine for viral infections

Beijing Entaiwei Medicine Science Technology Co. Ltd. has described prodrugs of β-D-N4-hydroxycytidine reported to be useful for the treatment of viral infections. Read More

Other news to note for Aug. 23, 2023

Additional early-stage research and drug discovery news in brief, from: Hanx Biopharmaceuticals, Novavax. Read More

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