Some autoimmune diseases are different in women and men. A group of researchers from the Chinese Academy of Sciences (CAS) has found a strong female bias in the response of a neurotransmitter receptor that is involved in many neurological processes. Their study identified the hyperactivity of the dopamine D2 receptor (DRD2) in the intestine and associated it with the progression of multiple sclerosis (MS) in female mice. Read More
5’-AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that regulates energy levels by sensing cellular fuel status and it is highly expressed in metabolic tissues, such as adipose tissue, where it is activated upon energy deprivation or cellular stress stimuli, among others. Read More
Mira Pharmaceuticals Inc. has reported findings on the cognitive enhancing effects of MIRA-1a, an unscheduled novel synthetic tetrahydrocannabinol (THC) analogue, in normal mice. Read More
After an initial chemical screening, researchers at the University of Pennsylvania and Weill Cornell Medicine identified the Chk1/Chk2 dual inhibitor AZD-7762 among the strongest to induce insulin secretion in various assays. Read More
Siteone Therapeutics Inc. has disclosed sodium channel protein type 10 subunit α (SCN10A; Nav1.8) blockers reported to be useful for the treatment of pain. Read More
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder where visceral hypersensitivity (VH), which causes discomfort and negatively impacts the quality of life, is influenced by stressful events. In recent years, the use of bifidobacteria and lactic acid bacteria has shown anti-VH efficacy. Read More
Human dihydroorotate dehydrogenase (hDHODH) is a mitochondrial enzyme participating in de novo pyrimidine biosynthesis essential for T- and B-lymphocyte proliferation. Read More
Researchers from Lerna Biopharma Pte. Ltd. (formerly Cargene Therapeutics Pte. Ltd.) recently presented the discovery and preclinical evaluation of a first-in-class GalNAc-siRNA therapeutic, CG-LR1, being developed for the treatment of liver diseases. Read More
Serpin Pharma LLC has identified serpin peptide derivatives acting as pro-low-density lipoprotein receptor-related protein 1 (LRP-1) agonists reported to be useful for the treatment of acute lung injury, eosinophilic esophagitis, viral infection, and acute and neuropathic pain, among others. Read More
Researchers from Abbvie Inc. have reported on the discovery and optimization of a series of selective tyrosine kinase 2 (TYK2) inhibitors that led to the identification of ABBV-712 as the lead compound. Read More
Viscient Biosciences LLC has divulged tryptanthrin derivatives acting as indoleamine 2,3-dioxygenase 2 (IDO-2) inhibitors reported to be useful for the treatment of cancer and autoimmune disease. Read More
Chia Tai Tianqing Pharmaceutical Group Co. Ltd. has described pyrazole-substituted cyclopentanol ester derivatives acting as CDK2/cyclin E1 and CDK2/cyclin A2 inhibitors reported to be useful for the treatment of cancer. Read More
Researchers from Weifang Medical University and affiliated organizations have published details on the discovery of novel hepatitis B virus (HBV) capsid assembly modulators (CAMs). Read More
