Investigators at the National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK) have used a gene-constrained analysis to identify nine new Alzheimer’s disease (AD) risk genes that are possibly linked to the higher prevalence of AD in people with African ancestry. One of those genes, GNB5, regulates the stability of certain G protein-signaling proteins, which are activated by G protein-coupled receptors (GPCRs). The authors showed that mice with only one copy of Gnb5 developed more amyloid plaques and tau tangles than those with two copies. Read More
Tropomyosin receptor kinases (TRKs), encoded by neurotrophic receptor tyrosine kinase (NTRK) genes, are involved in cell proliferation, differentiation and apoptosis, and are validated therapeutic targets for cancer treatment. Read More
Researchers from the Yale University School of Medicine have developed a novel murine model of Gaucher disease type I with the aim to investigate the impact of GBA1 deficiency on hematopoiesis and the immune system, in order to elucidate potential therapeutic targets. Read More
Genome sequencing has identified several single-nucleotide polymorphisms (SNPs) tied to osteoporosis, but most of them are located in noncoding regions. Investigators identified a SNP which impacted the YY2-PAPSS2 axis and risk of osteoporosis; the PAPSS2 gene encodes bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 2. Read More
Researchers from Mercer University have presented a middle cerebral artery/ferric chloride (MCA/FeCl3) thromboembolic mouse model of COVID-19-induced stroke and cerebrovascular complications. Read More
Investigators from the Chinese Academy of Medical Sciences & Peking Union Medical College presented data from a study that investigated the regulatory mechanisms of intestinal epithelial cell (IEC) death and intestinal inflammation. Read More
Nanjing Tian Yin Jian Hua Pharma Tech Co. Ltd. has disclosed receptor-interacting serine/threonine-protein kinase 1 (RIPK1; RIP-1) inhibitors acting as necroptosis inhibitors reported to be useful for the treatment of amyotrophic lateral sclerosis, ulcerative colitis, multiple sclerosis, psoriasis, rheumatoid arthritis and Alzheimer’s disease, among others. Read More
Ohio State University has synthesized DNA topoisomerase II (bacterial) inhibitors reported to be useful for the treatment of Staphylococcus aureus infections. Read More
The gastrin-releasing peptide receptor (GRPR) is overexpressed in several types of tumors and is considered a target for theranostic strategies. Read More
Betta Pharmaceuticals Co. Ltd. has identified estrogen receptor α (ER-α; ESR1) degradation inducers reported to be useful for the treatment of cancer. Read More
GSK plc has exercised its option to a nonexclusive license to Elsie Biotechnologies Inc.’s discovery platform, following a successful research collaboration both companies entered into last year to explore platform capabilities. Read More
Vantai Inc. and Bristol Myers Squibb Co. have entered into a strategic collaboration to discover new molecular glues for therapeutic targets of interest. Read More
Nextgen Bioscience Co. Ltd. has divulged ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2; autotaxin) inhibitors reported to be useful for the treatment of cancer, fibrosis, cardiovascular, inflammatory, respiratory, metabolic, eye and renal disorders, among others.< Read More
Ono Pharmaceutical Co. Ltd. has entered into an option and collaboration agreement with Numab Therapeutics AG to develop and commercialize a novel multispecific macrophage engager, NM-49, in oncology. Read More
Precision Biosciences Inc. has received pre-IND regulatory feedback from the FDA and ex-U.S. agencies providing alignment and clarity on Precision's final IND/CTA-enabling preclinical plans and clinical strategy for PBGENE-HBV. Read More
Shaanxi Synthetic Pharmaceutical Co. Ltd. has described compounds reported to be useful for the treatment of coronavirus acute respiratory syndrome. Read More
