Increased life expectancy also comes with age-related diseases. But what causes one to age? Although there is no single answer, scientists at Duke-National University of Singapore (NUS) have shown in mice that interleukin-11 (IL-11) promoted aging. Blocking it improved health and lifespan. Read More
Proteasome inhibitors such as bortezomib have shown promise in ovarian cancer treatment but limitations like route of administration or severe side effects restrict their use. Targeting proteasomal ubiquitin receptor ADRM1, also known as RPN13, has emerged as an alternative strategy and some RPN13 inhibitors are in early development. Read More
Researchers from Shandong University and affiliated organizations have presented data from a study that aimed to assess the role of endosome-associated trafficking regulator 1 (ENTR1) in adipogenesis. Read More
Tiximed Inc. has received IND clearance for its inhibitor of thioredoxin-interacting protein (TXNIP), TIX-100, in individuals with type 1 diabetes. TIX-100 is a potent and specific inhibitor of TXNIP. Read More
F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have synthesized new benzimidazole derivatives acting as serine/threonine-protein kinase SIK inhibitors. Read More
Frontier Medicines Corp. has advanced lead candidates for further optimization in an Abbvie Inc.-partnered program targeting a key transcription factor for cancer cell survival, triggering an accompanying milestone payment. Read More
From no hope to viable treatments, BioWorld is there to cover the breakthroughs in medicine. Listen to Randy Osborne explain why the BioWorld team is ‘always on the lookout for what's next.’ Read More
The symptoms of allergic rhinitis (AR), such as nasal congestion, runny nose or sneezing, start within minutes of allergen exposure after mast cells release mediators such as histamine, prostaglandins and leukotrienes. Read More
Pinetree Therapeutics Inc. has entered into an exclusive option and global license agreement with Astrazeneca plc for a preclinical epidermal growth factor receptor (EGFR) degrader candidate. Read More
Work at Intra-Cellular Therapies Inc. has led to the identification of heterocycle fused gamma-carbolines characterized as 5-HT2A receptor ligands reported to be useful for the treatment of neurological disorders. Read More
Dent disease (DD) is an X-linked recessive disorder characterized by low molecular weight proteinuria (LMWP), kidney stones and progressive kidney failure. Read More
A joint Astrazeneca AB and Mitsubishi Tanabe Pharma Corp. patent details NLRP3 inflammasome inhibitors reported to be useful for the treatment of liver, autoimmune and inflammatory bowel disease, inflammation, respiratory, cardiovascular and renal disorders. Read More
Chengdu Mfs Pharma Co. Ltd. has disclosed substituted phenol derivatives potentially useful as analgesics, sedatives, hypnotics and anesthetics. Read More
Triastek Inc. and Biontech SE have entered into a research collaboration and platform technology license agreement for the development of RNA therapeutics for oral delivery based on Triastek’s Melt Extrusion Deposition (MED) 3D printing technology. Read More
