Cellular atlases and omics studies, such as genomics, transcriptomics and proteomics, have become key tools for identifying the diversity of all the elements that make up the cardiovascular system. These approaches help scientists understand how cells, genes and molecules function and interact in both healthy and diseased conditions, revealing critical points where targeted interventions could not only relieve symptoms but potentially reverse the underlying pathology at its origin. Read More
Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent form of pancreatic cancer and presents a 5-year survival rate of less than 10%. Novel therapies focusing on targeting the tumor microenvironment and dysregulated molecular signaling pathways are emerging as potential options for intervention. Read More
Chugai Pharmaceutical Co. Ltd. and Gero Pte Ltd. have entered into a joint research and license agreement to develop novel therapies for age-related diseases. Chugai will create novel antibody-drug candidates for new drug targets discovered by Gero using its AI target discovery platform. Read More
The neurotropic alphavirus group includes Eastern equine encephalitis virus (EEEV), Venezuelan equine encephalitis virus (VEEV) and Western equine encephalitis virus (WEEV). These viruses exhibit a strong tropism for the CNS, often resulting in encephalitis. In some cases, infection can progress to severe neurological disease, including coma or death. Read More
A team of researchers at the University of British Columbia investigated the potential of radiopharmaceutical therapy based on Terbium-161 (161Tb) both in vitro and in vivo using a novel tracer, [161Tb]Tb-BL34L20S, which uses the C-X-C chemokine receptor type 4 (CXCR4)-targeting peptide BL34L20S labeled to 161Tb. Read More
Hutchinson-Gilford progeria syndrome (HGPS), an extremely rare genetic disorder, arises when a silent point mutation in the gene encoding the nuclear envelope protein lamin A, LMNA, leads to abnormal splicing of LMNA mRNA. Read More
Beijing Konruns Pharmaceutical Co. Ltd. has disclosed tyrosine-protein kinase yes (YES1) inhibitors reported to be useful for the treatment of cancer. Read More
Alterome Therapeutics Inc. has synthesized RAC-α serine/threonine-protein kinase (AKT1; PKB α) (E17K mutant) inhibitors reported to be useful for the treatment of cancer. Read More
Age-related macular degeneration (AMD) is a leading cause of vision loss in older adults. Current treatments mainly address advanced AMD, while early or intermediate stages rely only on micronutrient supplements. This highlights a critical gap in understanding the molecular drivers of early dry AMD and the need for strategies to prevent progression to geographic atrophy or choroidal neovascularization and vision loss. Read More
Deciphera Pharmaceuticals LLC has identified phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3; Vps34) inhibitors reported to be useful for the treatment of cancer. Read More
Acurex Biosciences Corp. has divulged fused quinone compounds acting as ferroptosis inhibitors reported to be useful for the treatment of mitochondrial disease. Read More
Arrhythmogenic cardiomyopathy is an inherited disorder that typically manifests in people younger than 40 years and for which only palliative treatments exist. For advanced cases, heart transplantation is the only therapeutic option. Read More
Grünenthal GmbH has described sodium channel protein type 10 subunit α (SCN10A; Nav1.8) blockers reported to be useful for the treatment of pain. Read More
Additional early-stage research and drug discovery news in brief, from: Artelo Biosciences, Cyclacel Pharmaceuticals, Hanmi Pharmaceuticals, Hotspot Therapeutics. Read More
