Repros Therapeutics Inc., of The Woodlands, Texas, dosed its first patients in a low-dose study of Proellex for uterine fibroids and endometriosis. Previous studies at a 50-mg dose were held when some subjects experienced severe liver toxicity. The new study will enroll five cohorts at doses from 1 mg to 12 mg per day, starting with the lowest cohort and not progressing to the next dose until an outside drug safety monitoring committee has reviewed the liver safety data from the previous.