European Patent Disclosures Published Jan. 7, 13 (EPO), Jan. 7(WO), Jan. 6 (GB)

Hoffmann-La Roche AG Coccidiosis EPO 522 482Basel, Switzerland vaccines.Immunogenic polypeptide inducing immune response againstEimeria parasites, its DNA sequence, transformedmicroorganisms, vaccines.

Intl. Flower Develop. Pty. Flavonoid EPO 522 880Collingwood, Australia pathway enzymesNucleotide sequence encoding a dihydrokaemferolhydroxylating enzyme; transgenic plants carrying andexpressing this nucleic acid .

Kabi Pharmacia Ab Tumor antigen EPO 521 842Uppsala, Sweden specific antibodyA monoclonal antibody that reacts with the CA-242 antigen ;hybridomas producing it; useful for cancer diagnosis, therapy.

Korea Inst. Sci.&Tech. Hepatitis B EPO 521 348Seoul, Korea chimeric antibodyRecombinant murine/human chimeric antibody againsthepatitis pre-S2 surface antigen; cell line producing it; forprevention, treatment.

Lucky Ltd. Hepatitis C EPO 521 318Seoul, Korea diagnosis, vaccinePolynucleotides derived from "KHCV" hepatitis C virus, encodedpolypeptides, derived antibodies, for diagnosis, prevention.

N.E. Deaconess Hospital Megakaryocyte WO 93/00433Boston differentiationIntroducing activated oncogene into blast-megakaryocytespermits differentiation; also, differentiation factors andplatelets.

NIH (Natl.Insts.Health) NIH patented WO 93/00353Bethesda, Md. sequencesPartial and complete human cDNA sequences, generally 150 to500 bp, derived from human brain cDNA libraries. [N.B. This isone of the controversial NIH patent-seeking sequencesdeveloped by inventor J. Craig Venter.

Novo Nordisk AS Pancreatic WO 93/00426Bagsvaerd, Denmark lipasesGenetically engineered, highly purified guinea-pig lipase, aswell as human pancreatic lipase variants,for detergents,digestive enzymes.

Osaka Bioscience Inst. Granulocyte EPO 521 156Osaka, Japan CSF receptorA stable supply of G-CSF receptor for research and clinical use,obtained byprobing a human library of placental or lymphomagenes.

Pasteur Inst. Actinomycetale EPO 521 220Paris vaccineMycobacterium transformed with antigen-encoding gene,controlled by a Streptomyces stress-response promoter.

Pasteur Institute Papilloma- WO 93/00435Paris virus diagnosisDNA sequence encoding all or part of human papillomavirus 42genome, for in vitro differentiation of carcinoma from benigninfection.

Princeton University Stem cell WO 93/00349Princeton, N.J. receptors, ligandsIsolated mammalian DNA sequences encoding totipotentreceptor protein tyrosine kinases expressed in primitive, butnot mature, hematopoetic cells.

Probicom Research BV Recombinant EPO 522 203Bolsward, Netherlands endopeptidaseGene encoding lactic acid bacterial endopeptidase; transformedorganisms expressing it; for use in cheese and meat products.

Quest Intl. Non-lysing EPO 521 240Naarden, Netherlands bacteriocideBacteriocin derived from a Lactococcus lactis subspecies;sequenced DNA and polypeptide encoded thereby; productionand use.

Rhone-Poulenc Rorer Intl. Von Wille- WO 93/00357Lewes, Del. brand therapeuticA recombinant polypeptide patterned on a fragment of wild-type von Willebrand factor subunit, for treatment ofthrombosis.

Rhone-Poulenc Rorer SA Recombinant EPO 521 767Antony, France yeast hostsNew lines of Kluyveromyces lactis yeast cells, modified bygenetic engineering, for expression of recombinant proteins.

Rhone-Poulenc Rorer SA Cloning/ WO 93/00437Antony, France expression vectorsCloning and expression vectors derived from a new yeastplasmid.

Shionogi & Co. Ltd. Human endo- EPO 522 868Osaka, Japan thelin receptorDNA encoding an endothelin receptor isolated from cDNAderived from human placenta.

Squibb & Sons, Inc. trkC protein EPO 522 530Princeton, N.J.DNA sequences encoding all or part of a trkC protein;expression vectors; host organism; Polypeptides comprising allor part of a trkC protein.

Sumitomo Denko Kogyo PCR-based WO 93/00428Osaka, Japan DNA preparationProcess involves preparing a chain DNA plus primer,synthesizing complementary chain and polymerase to doublehelix, repeating replication.

Vanderbilt University Detecting gene WO 93/00445Nashville, Tenn. deletionsIn a suspected genomic DNA sample, deletion is a fusionfragment of two homolgous flanking regions; PCR amplificationreveals deletion.

(c) 1997 American Health Consultants. All rights reserved.

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