In May, when Aquinox Pharmaceuticals Inc. signed its potential $155 million deal with Astellas Pharma Inc. for once-daily, oral rosiptor (AQX-1125) for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS), hopes ran high for the first-in-class SHIP1 activator, which seemed on track to become the first such therapy to reach the market in 20 years.