Published May 3 (EPO); April 27 (WO); May 3 (GB)
Affibody Technol. WO 00/23580
Affinity separation methods
Methods of affinity separation using immobilized proteinaceous ligands having modified asparagine.
Alabama, Univ. of WO 00/23623
Fas promoter polymorphisms
Fas/Fas ligand promoter polymorphisms; for determining the risk of autoimmune disease and non-lymphatic cancer.
Albani, S. WO 00/23053
T cell isolation
Liposomes containing MHC peptide complexes bound to solid supports; for retrieving antigen-specific T cells.
Arch Develop. WO 00/23603
Type 2 diabetes genes
Identification of genes associated with type 2 diabetes, encoded proteins; for diagnostics and therapeutics.
Ariad Gene Therapeutics WO 00/23600
Domains for conditional self-aggregation in endoplasmic reticulum, fusion proteins, encoding gene sequences.
Ariad Gene Therapeutics WO 00/23602
Domains for conditional retention in endoplasmic reticulum, fusion proteins containing them, encoding gene sequences.
Aventis WO 00/23604
Protein production system
Expression vectors having Stylonychia lemnae regulatory sequences; for heterologous protein production.
Avigen WO 00/23116
Factor VIII expression
Adeno-associated vectors for the expression of Factor VIII in transfected target cells.
Biogen WO 00/23472
Interferon-_ fusion proteins, mutants; for affecting the immune system.
Bioimage WO 00/23091
Reduced cAMP cleavage
Dislocation of cyclic nucleotide phophodiesterases from their anchoring sites; for reduced cleavage of cAMP.
Bioimage WO 00/23615
Cellular response measure
Detection of intracellular translocation/redistribution of biologically active proteins to measure cellular response.
Bios Group WO 00/23933
Genetic regulatory networks
Santa Fe, N.M.
Experimental and algorithmic methods for analyzing genetic regulatory networks and grouping genes into them.
Boehringer Ingelheim WO 00/23584
Cancer immunotherapy antigen
Alternate translation product of a tumor-associated antigen, antigenic peptides, encoding gene; for cancer immunotherapy.
Brownlee, M. WO 00/23568
Reducing reactive oxygen species
Identifying agents that reduce mitochondrial overproduction of reactive oxygen species in cells.
California, Univ. of WO 00/23579
Antibodies from yeasts
Large-scale production of functionally assembled antigen-specific intact recombinant antibodies in yeasts.
Carlsson, B., et al. WO 00/23475
Intracellular C-terminal HDL receptor domain peptides, analogs, fragments, encoding genes; for hyperlipidemia.
Children's Hosp. WO 00/23569
Transgenic emphysema model
Transgenics lacking surfactant protein D and its encoding gene; for modeling emphysema and finding therapeutics.
Chugai EPO 997 152
Lymphatic tumor antibodies
Specific antibodies that have cytotoxic activity and can be used as therapeutics against lymphatic tumors.
Chugai WO 00/23610
Reduced cytokine inflammation
Inhibition of TAK1 signal transduction; for reduced production of inflammatory cytokines.
City of Hope WO 00/23573
Cancer T-cell therapy
CD20-specific redirected T cells; for cellular immunotherapy of CD20+ malignancies.
Cognetix WO 00/23092
Salt Lake City
Contulakin-G, analogs, encoding gene sequences; for anti-inflammatory therapeutics.
CSIRO (Comm. Sci. Ind. Res. Org.) WO 00/23601
Less antigenic drug delivery
Encapsulation of growth hormones within semipermeable membranes; for drug delivery with lesser immune response.
Cornell Univ. WO 00/23571
Transfection of cell preparations with an oligodendrocyte-specific promoter linked to a reporter; for cell separation.
Curagen WO 00/23100
New Haven, Conn.
16 genes differentially expressed in hypertensive rats; for developing therapeutics for hypertension and renal failure.
Delta Biotech GB 2 343 184
Protein production system
Modification of Ubc4p/5p activity in fungal cells; for increasing recombinant protein production.
Duke Univ. WO 00/23624
Proliferative disease screen
Measuring upregulation of the CLN3 gene; for screening for the risk of proliferative diseases.
Fordham Univ. WO 00/23093
Tissue repair promotion
Heat shock proteins complexed with antigenic molecules; for promoting tissue repair.
Gardella, T.J., et al. WO 00/23594
Bioactive PTH peptides
Bioactive peptides and derivatives of parathyroid hormone (PTH) and PTH-related peptide; for bone therapeutics.
Gemini Research WO 00/23618
Polymorphism in a TGF-SS gene correlated with osteoporosis; for diagnostics and therapeutics.
Genvec WO 00/23088
Inhibiting adenoviral immunoresponse
Using systemic neutralizing antibodies to inhibit immune responses during adenoviral-based gene therapy.
Georgetown Univ. WO 00/23590
Regulating NFkappaB activation
Modulators of TRAF3 degradation; for controlling TRAF3-mediated CD40 regulation of NFkappaB activation.
Georgia, Med. Coll. of WO 00/23606
Enhancer, insulator, and promoter sequences from human-like globin genes; for use in retroviral vectors.
Hook, V.Y.H. WO 00/23576
La Jolla, Calif.
Selecting secretases that cleave amyloid precursor protein; for inhibiting Alzheimer's A_ protein peptide production.
Human Genome Sciences WO 00/23572
TNF receptor-related gene
TNF receptor-related gene 12, encoded protein, protein production methods; for diagnostics and therapeutics.
Immunex WO 00/23094
Platelet activation inhibition
Soluble CD39 polypeptides; for inhibiting platelet activation and recruitment.
Incyte Genomics WO 00/23466
RNA binding proteins
Palo Alto, Calif.
Human RNA binding proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/23589
Palo Alto, Calif.
Proliferation- and apoptosis-related proteins, encoding gene sequences, antibodies, modulators; for therapeutics.
Introgene WO 00/23587
Alzheimer's gene therapy
Leiden, the Netherlands
Gene therapy for Alzheimer's disease by delivering the apolipoprotein E gene in humanized glial cells.
Japan Sci. & Technol. WO 00/23468
Human signal transducing proteins STAM2a and STAM2b, encoding gene sequences, antibodies.
Japan Sci. & Technol. WO 00/23586
Human signal transducing protein Gfr40, encoding gene sequences, antibodies.
Japan Tissue Engineering WO 00/23582
Transfected cell grafts
Mucosal epithelial cell sheet that has had its cells transfected with a therapeutic gene; for making grafts.
Keygene WO 00/23620
Wageningen, the Netherlands
Generation of DNA fingerprints using fragmentation and amplification of sample nucleic acids
Krebs Res. Ctr. WO 00/23583
Apoptosis modulator assay
Identification of p53 binding areas on the CD95 DNA receptor; for finding apoptosis modulators.
Leukosite WO 00/23599
ER protein degradation
Human proteins responsible for degradation of proteins in the endoplasmic reticulum (ER).
Ludwig Inst. Cancer Res. WO 00/23565
Neuropilin binding antagonist
Neuropilin receptor extracellular domain, ligand-binding fragment, analogs, antibodies; for antagonists.
Ludwig Inst. Cancer Res. WO 00/23625
Nuclear body-associated proteins
SCP proteins, encoding gene sequences; for analysis of SCP proteins associated with nuclear bodies.
Marine Biotech Inst. EPO 997 536
Topoisomerase gene footprint
Methods of identifying eukaryotes using a gene sequence in the intron-containing region of type II topoisomerase gene.
Methylgene WO 00/23112
St. Laurent, Que.
Modulation of mammalian gene expression regulated by methylation by using antisense oligos.
Millennium Pharma WO 00/23470
NIP2 protein homologs
NIP2 protein homologs, encoding gene sequences, fusions, antigenic peptides, antibodies, transgenics.
Millennium Pharma WO 00/23588
G-protein coupled receptors
G-protein coupled receptors, encoding genes; for modulator screens, diagnostics, and therapeutics.
Millennium Pharma WO 00/23784
Type II diabetes risk
Measurement of mutations in carboxypeptidase E and its encoding gene; for determining type II diabetes risk.
Montana, Univ. of WO 00/23595
Neisseria gonorrhoeae and N. meningitidis Omp85 proteins, encoding genes; for treating gonorrhea and meningitis.
NIH (Natl. Inst. Hlth.) WO 00/23955
Antibodies for chronic disease
Chimeric virus-like particles for inducing autoantibodies to treat chronic infection, inflammation, and cancer.
Novartis WO 00/23567
Hematopoietic stem cell renewal
Promotion of hematopoietic stem cell self-renewal by treating with histone deacetylase and its inhibitors.
Noxxon Pharma WO 00/23616
Amplifying molecular matrices
Iterative exponential amplification of molecular matrices in solid phase systems using reversible linkers.
Opperbas Holding WO 00/23115
Trauma antibody therapeutics
Amsterdam, the Netherlands
Treatment of trauma and graft rejection using liposomes with DNA encoding CTLA4 immunoglobulin or CD40 ligand antibodies.
Otsuka Pharma WO 00/23476
Neovascular-specific peptides, dendrimer preparations; for selectively delivering drugs to cancer tissues.
Pfizer EPO 997 528
Increased avermectin production
Streptomyces avermitilis genes that regulate avermectin polyketide synthase; for increased production.
Powderject Vaccines WO 00/23592
Minimal promoters; for linkage to transfected genes and use in expression of foreign proteins for vaccines.
Queensland, Univ. of WO 00/23474
Searchable computer database with three-dimensional protein structure framework entries; for protein engineering.
Schering-Plough EPO 997 476
Langerhans cell antibodies
Antibodies to a mammalian Langerhans cell antigen, purified proteins, encoding gene sequences; for diagnostics.
Scripps Res. Inst. WO 00/23456
La Jolla, Calif.
Modified pyrimidines that contain functional groups that mimic naturally occurring amino acid residues.
Signal Pharma WO 00/23581
Transcription and replication modulators
Plasmid dual reporter systems for the independent evaluation of modulators of transcription and replication.
Singer, R.H., et al. WO 00/23621
Intracellular RNA visualization
Visualizating the location and movement of RNAs in living cells in real time using a fluorescent binding protein.
Smith, S.J. WO 00/23799
Quantifying cellular protein
Quantifying cellular proteins in tissue by using a cell imaging densitometer.
SmithKline Beecham WO 00/23467
Bacterial birA polypeptides, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/23574
Hepatitis A vaccines
Inactivated hepatitis A virus free of host cell contamination; for vaccines.
SmithKline Beecham WO 00/23575
Bacterial ugc polypeptides, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/23611
Bacterial fabG polypeptides, encoding genes, recombinant production methods; for antibacterial screens.
South Carolina, Med. Univ. of WO 00/23469
IGF diabetes treatment
Fragments of insulin-like growth factor (IGF) and IGF binding protein; for preventing diabetes complications.
Spectral Diagnostics WO 00/23585
Diagnosing heart attacks
Stable, circulating degradation polypeptides of cardiac troponin I; for heart attack diagnostics.
Sunol Molecular EPO 997 477
MHC fusion complexes
MHC molecule fusion complexes; for identifying peptides that modulate T cell activity and induce immune responses.
Sunol Molecular WO 00/23087
Polyspecific binding molecules
Single-chain polyspecific binding molecules having a single-chain T-cell receptor and a single-chain antibody.
Takara Shuzo EPO 997 530
DNA polymerase-related factors
Thermostable DNA polymerase-associated factors that can enhance the DNA synthesizing activity of DNA polymerase.
Tepnel Medical WO 00/23619
Detecting single-stranded DNA
Template chain reactions used for the detection of single-stranded target nucleic acid sequences.
Texas, Univ. of WO 00/23596
Cholesterol 25-hydroxylase, gene probes and primers; for screening modulators of serum cholesterol.
Texas Heart Inst. WO 00/22929
Gene transfer of human E2F-1 gene to vascular smooth muscle cells; for regressing atherosclerotic plaques.
U-Bisys WO 00/23570
Altering cell membranes
Utrecht, the Netherlands
Altering properties of cells or particles with cellular membranes using lipid-modified proteinaceous molecules.
Valigene WO 00/23622
Sorting cDNA libraries
Labeling, sorting, and screening cDNA libraries using specific peptide-labeled oligonucleotides as tags.
Washington Univ. WO 00/23083
Anti-apoptotic BAX proteins
Truncated BAX polypeptides that are anti-apoptotic in neurons; for inhibiting neurodegeneration.
Xencor WO 00/23564
Protein design automation
Protein design automation for generating computationally prescreened secondary libraries of proteins.
Yeda Res. & Develop WO 00/23082
Lupus erythematosus therapy
Down-regulating the autoimmune response to the C-terminal DNA-binding domain of p53; for treating lupus erythematosus.
Zymogenetics WO 00/23591
Secreted pancreatic protein
Highly expressed secreted pancreatic protein, encoding chromosome 1 gene, polymorphisms; for diagnostics.