Depuy Synthes Companies, of Raynham, Mass., part of Johnson & Johnson, said an exclusive agreement has been signed in the U.S. between Depuy Synthes Sales Inc. and Pacira Pharmaceuticals Inc., of Parsippany, N.J., to co-promote Exparel (bupivacaine liposome injectable suspension), a long-lasting, non-opioid, local analgesic administered at the orthopedic surgical site.