As Biocryst Pharmaceuticals Inc. prepared to close its $45 million financing round last week, work continued with BCX7353 and second-generation compounds for hereditary angioedema (HAE). So did speculation about the oral, second-generation kallikrein inhibitor's chances in the crowded HAE space, as company watchers mulled interim outcomes unveiled in late February from APeX-1, a phase II dose ranging trial.