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BioWorld - Saturday, April 25, 2026
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Home » Surprise upset: Bellerophon tanks on phase III miss in PAH
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Surprise upset: Bellerophon tanks on phase III miss in PAH

Aug. 8, 2018
By Jennifer Boggs
The team at Bellerophon Therapeutics Inc. intends to further analyze data after an unexpectedly disappointing interim look at the phase III INOvation-1 study testing its inhaled nitric oxide delivery system in pulmonary arterial hypertension (PAH) failed to show sufficient improvements in the six-minute walk distance (6WMD), the primary endpoint. That review prompted the data monitoring committee (DMC) to recommend the study be stopped for futility and sent shares of the Warren, N.J.-based company (NASDAQ:BLPH) falling more than 68 percent Tuesday.
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