DUBLIN – The B-cell antigen CD19 is, of course, the target of choice for the first wave of chimeric antigen receptor T-cell (CAR T-cell) therapies to secure FDA approval this year. ADC Therapeutics Sarl and Morphosys AG both reported clinical data at the American Society of Hematology Annual Meeting in Atlanta this week, which also confirms its potential as a target for antibody-based therapies as well – but only in the context of engineered antibodies that have additional properties beyond what conventional antibodies can offer.