BioWorld looks at translational medicine, including: Prozac for infectious disease; How CDK comes unglued; Macrophages rewire cholesterol metabolism for bacterial toxin defense; ApoE4’s role in Alzheimer’s blood vessels; HRAS-driven translation helps skin prevent tumors; Discovering pharmacological enzyme activators; Broad-spectrum antiviral has activity against Zika; Lifespan synaptic atlas gives developmental insights; NETS and mets.