I. COMMENCED TRADING IN NOVEMBER
Company (Symbol)# Date Filed Date Comm. Shares/Units (M) Price Shares Out (M)@ Lead, Other Underwriters Gross (US$M) Post-Offering Market Cap (M)%

INITIAL OFFERINGS
ARYx Therapeutics Inc. (ARYX)1 8/31/07 11/7/07 5S $10 17.5 Morgan Stanley & Co.
CIBC World Markets
Jefferies & Co. Inc. Leerink Swann & Co.
$50 $175
Medgenics Inc.
(AIM:MEDG)
11/29/07 11/29/07 N/A £0.1
($0.21)
104S SVS Securities
Blomfield Corp. Finance (adviser)
£3.28
($6.76)
£10.4
($21.1)
Nanoshere Inc.
(NSPH)2
8/13/07 11/1/07 7S $14 21.1 Credit Suisse
Piper Jaffray
Leerink Swann & Co.
Allen & Co. LLC
$98 $147.7
OVERALLOTMENTS
Genoptix Inc.
(GXDX)3
8/1/07 11/5/07 0.75S $17 16.35 Lehman Brothers
Banc of America Sec.
Cowen and Co.
$12.75 $277.95
Total: $167.51M
Number of IPOs in November: 3
Number of IPOs in 2007: 39
Average value of November IPOs: $55.84
Total raised in IPOs in 2007: $1,814.56M
Average value of IPOs in 2007: $46.53M
FOLLOW-ON OFFERINGS
Arena Pharmaceuticals Inc. (ARNA)4 10/22/07 11/2/07 11S $9.91 72.2 CIBC World Markets
UBS Investment Bank (co-lead)
$109.01 $715.5
Biopure Corp. (BPUR)5 11/1/07 11/1/07 19.4S $0.85 35.0 Dawson James Sec. $16.5 $29.75
Total: $125.51M
Number of follow-on offerings in November: 2
Number of follow-on offerings in 2007: 49
Average value of November follow-ons: $62.76M
Total raised in follow-ons in 2007: $2,855.49M
Average value of follow-ons in 2007: $58.28M

Notes:
# Unless otherwise indicated, shares are traded on the Nasdaq exchange. @ This column reflects the shares outstanding following the offering, when disclosed. % Market capitalization is calculated based on the offering price. Currency conversions are based on exchange rates at the time of the deal. AIM = Alternative Investment Market on the London Stock Exchange.
1 ARYx's overallotment option: 750,000 shares. 2 Nanosphere's overallotment option: 1.05M shares.
3 Genoptix's exercised overallotment option brings the total raised to $85.9M. 4 Arena's overallotment option: 1.65M shares.
5 Biopure's offering includes the overallotment option. Each new share was accompanied by a five-year warrant to buy one additional share at an exercise price of $1.06.
II. FILED AND PENDING
Company (Symbol/Proposed Symbol)#* Date Filed Shares/Units (M) Price Range Shares Out (M)@ Lead, Other Underwriters Value (M)
INITIAL OFFERINGS
Aegerion Pharmaceuticals Inc. (AEGR) 11/21/07 N/A N/A N/A Piper Jaffray
Thomas Weisel Partners (co-lead)
Lazard Capital Markets Collins Stewart LLC
$86
Anacor Pharmaceuticals Inc. (ANAC) 8/31/07 N/A N/A N/A Morgan Stanley & Co. Inc.
Cowen & Co. LLC (co-lead) Pacific Growth Equities LLC
Needham & Co. LLC
$57.5
Archemix Corp. (ARCH) 7/25/07 N/A N/A N/A Banc of America Securities
Bear, Stearns & Co. Inc. Cowen and Co.
$69
Bioheart Inc. (BHRT) 2/13/07 3.575S $14-$16 16.9 BMO Capital Markets Corp.
Janney Montgomery Scott (co-lead)
Merriman Curhan Ford & Co.
$53.6
Biolex Inc. (BLEX) 8/14/07 N/A N/A N/A Lehman Brothers Inc.
Deutsche Bank Securities (co-lead)
Leerink Swann & Co. Inc.
$70
Chemocentryx Inc. (CCXI) 11/12/07 N/A N/A N/A Credit Suisse Securities LLC
Cowen and Co. Leerink Swann
Lazard Capital Markets
$57.5
Elixir Pharmaceuticals Inc. (ELXR) 9/24/07 N/A N/A 143.5 Credit Suisse Securities LLC
Pacific Growth Equities Leerink Swann LLC
$86
Insys Therapeutics Inc. (INRX) 8/20/07 N/A N/A N/A Banc of America Securities
UBS Investment Bank (co-lead) JMP Securities
Natixis Bleichroeder
$86.25
Light Sciences Oncology Inc. (LSON) 4/21/06 5.25S $14-$16 18.5 Cowen & Co.
Wachovia Securities (co-lead) Jefferies & Co.
Thomas Weisel Partners
$78.75
Merrion Pharmaceuticals Ltd. (MERR) 4/3/07 4S $6-$7 15 Punk, Ziegel & Co.
Goodbody Stockbrokers Stanford Group Co.
$26
MonoSol Rx Inc. (MSRX) 5/14/07 4S $16-$18 N/A Cowen and Co.
CIBC World Markets Susquehanna Financial
$68
NovaBay Pharmaceuticals Inc. (AMEX:NBY; TSX:NBY) 2/15/07 5S $4-$6 21.1 Dundee Securities
Desjardins Sec. International
Blackmont Capital
Dawson James Sec.
$25
Peplin Inc. (PLIN) 8/10/07 N/A N/A N/A Merrill Lynch & Co.
Cowen & Co. LLC
Thomas Weisel Partners
Leerink Swann & Co
Merrill Lynch International
Wilson HTM
$75
Precision Therapeutics Inc. (PRCN) 8/24/07 N/A N/A N/A JP Morgan
Piper Jaffray (co-lead) JMP Securities
$80.5
RXi Pharmaceuticals Corp. (RXIP; unit of CytRx Corp.) 10/30/07 10.8S N/A N/A N/A N/A
Talecris Biothera-peutics Holdings Corp. (TLCR) 7/30/07 N/A N/A N/A Morgan Stanley
Goldman Sachs & Co.
J.P. Morgan
$1B
XDx Inc. (XDXI) 10/24/07 N/A N/A N/A J.P. Morgan Securities Inc.
Morgan Stanley & Co. (co-lead)
Piper Jaffray & Co.
JMP Securities LLC
$86.3
FOLLOW-ON OFFERINGS
Bioxel Pharma Inc. (Canada; CDNX:BIP) 7/9/07 N/A N/A N/A Paradigm Capital
Laurentian Bank Sec.
N/A
Chemokine Therapeutics Corp. (Canada; TSX:CTI; OTC BB: CHKT) 5/30/07 N/A N/A N/A GMP Securities $25
WITHDRAWN AND POSTPONED
Company (Symbol)# Date Filed/Date Pulled Shares/Units (M) Price Range Shares Out (M) @ Lead, Other Underwriters Value (M)

MediciNova Inc.
(MNOV)1
10/25/07
11/9/07
6S $6.10 N/A Pacific Growth Equities
HSBC Punk Ziegel & Co.
Rodman & Renshaw
$36.6
Reliant Pharmaceuticals Inc. (NYSE:RRX)2 8/10/07
11/26/07
11.7S $25-$27 N/A Goldman, Sachs & Co.
Merrill Lynch & Co. (co-lead)
Bank of America Securities
Lazard Capital Markets
$304.2

Notes:
# Unless otherwise indicated, shares are traded on the Nasdaq exchange; general shelf registration statements are not included until action is taken on the filing. * Stock symbols for companies seeking to complete IPOs are proposed.
@ This column reflects the shares outstanding following the offering, when disclosed. The value of all offerings is based on either the midpoint of the price range listed in the company's SEC filing or the most recent closing stock price before the offering was announced. In some cases, the company has not disclosed the number of shares to be offered or a price range. Then, the value is the maximum aggregate offering price listed in the SEC filing.
N/A = Not available, applicable or reported. AMEX = American Stock Exchange; CDNX = Canadian Venture Exchange; NYSE = New York Stock Exchange; OTC BB = Over-the-Counter Bulletin Board; TSX = Toronto Stock Exchange.
1 MediciNova withdrew its offering due to general market conditions and unusual trading activity in its stock. 2 Reliant's IPO was withdrawn after GlaxoSmithKline plc made an offer to buy the company for $1.65 billion.