Underwriter

Biotechnology
Company
(Symbol)

Date
Priced

Offering
Price Per
Share

12/31/05
Share
Price

Offering
Gross
(M)

After-Market
Performance
(%)


Adams Harkness

Martek Biosciences Corp.(MATK) (co-lead)

1/21/05

$49.10

$24.60

$86.3

-50%

A.G. Edwards

CombinatoRx Inc. (CRXX) (IPO)

11/9/05

$7

$8.18

$48.3

+17%

Favrille Inc. (FVRL) (IPO)

2/2/05

$7

$4.05

$42

-42%

Banc of America
Securities

Amylin Pharmaceuticals Inc.(AMLN)

1/21/05

$22

$39.92

$202.4

+81%

Aspreva Pharmaceuticals Corp. (ASPV) (IPO; co-lead)

3/3/05

$11

$15.72

$91.1

+43%

Dendreon Corp. (DNDN) (co-lead)

12/7/05

$4.50

$5.42

$51.8

+20%

ISTA Pharmaceuticals Inc. (ISTA) (co-lead)

1/20/05

$8.88

$6.36

$56.2

-28%

Momenta Pharmaceuticals Inc. (MNTA)

7/21/05

$27.02

$22.04

$130.4

-18%

Threshold Pharmaceuticals Inc. (THLD) (IPO; co-lead)

2/4/05

$7

$14.45

$37.3

+106%

Baker Watts Stifel

Accentia Biopharmaceuticals Inc. (ABPI) (IPO)

10/28/05

$8

$5.05

$19.2

-37%

Bear, Stearns
& Co.

CuraGen Corp. (CRGN) (lead)

8/10/05

$5.50

$3.08

$22

-44%

Dynavax Technologies Inc. (DVAX) (lead)

10/11/05

$6.25

$4.21

$35.75

-33%

Favrille Inc. (FVRL) (IPO; lead)

2/2/05

$7

$4.05

$42

-42%

Bear, Stearns
& Co.

Idenix Pharmaceuticals Inc. (IDIX) (co-lead)

10/26/05

$20.61

$17.11

$150

-17%

Keryx Bio-pharmaceuticals Inc. (KERX) (co-lead)

7/15/05

$14.05

$14.64

$81.2

+4%

Myriad Genetics Inc. (MYGN) (co- lead)

11/3/05

$18.50

$20.80

$148.9

+12%

Panacos Pharmaceuticals Inc. (PANC) (co-lead)

10/6/05

$10.50

$6.93

$86.6

-34%

ZymoGenetics Inc. (ZGEN)

8/4/05

$18

$17.01

$135

-6%

BMO Nesbitt Burns

Aspreva Pharmaceuticals Corp. (ASPV) (IPO)

3/3/05

$11

$15.72

$91.1

+43%

Neurochem Inc. (NRMX)

3/4/05

$15.30

$14.22

$61.2

-7%

Brean Murray
& Co.

Keryx Biopharmaceuticals Inc. (KERX)

7/15/05

$14.05

$14.64

$81.2

+4%

C.E. Unterberg,
Towbin

Advanced Life Sciences Holdings Inc. (ADLS) (IPO; co-lead)

8/4/05

$5

$3.92

$32

-22%

ISTA Pharmaceuticals Inc. (ISTA)

1/20/05

$8.88

$6.36

$56.2

-28%

CIBC World Markets

Arena Pharmaceuticals Inc. (ARNA) (co-lead)

2/1/05

$6

$14.21

$51.75

+137%

Bioenvision Inc. (BIVN)

2/3/05

$8

$6.53

$60

-18%

Cardiome Pharma Corp. (CRME) (co-lead)

3/18/05

$6

$10.10

$58.65

+68%

CoTherix Inc. (CTRX) (co-lead)

10/6/05

$13

$10.58

$56.4

-19%

CIBC World Markets

CoTherix Inc. (CTRX) (co-lead)

2/10/05

$8.90

$10.58

$37.83

+19%

Durect Corp. (DRRX)

11/2/05

$5

$5.07

$41.1

+1%

Dynavax Technologies Inc. (DVAX)

10/11/05

$6.25

$4.21

$35.75

-33%

Favrille Inc. (FVRL) (IPO)

2/2/05

$7

$4.05

$42

-42%

Icagen Inc. (ICGN) (IPO)

2/3/05

$8

$6.45

$40.8

-19%

Myogen Inc. (MYOG)

9/16/05

$23.25

$30.10

$125

+29%

Neurochem Inc. (NRMX)

3/4/05

$15.30

$14.22

$61.2

-7%

Nuvelo Inc. (NUVO)

2/2/05

$7.50

$8.11

$73.31

+8%

Point Therapeutics Inc. (POTP) (co-lead)

11/22/05

$3

$3.45

$27.8

+15%

Progenics Pharmaceuticals Inc. (PGNX) (co-lead)

9/14/05

$23.90

$25.01

$59.75

+5%

Progenics Pharmaceuticals Inc. (PGNX) (co-lead)

4/1/05

$15.25

$25.01

$30.5

+64%

Renovis Inc. (RNVS)

9/23/05

$13.50

$15.30

$54

+13%

SeraCare Life Sciences Inc. (SRLS) (lead)

5/25/05

$12.25

$8.87

$42.6

-28%

Threshold Pharmaceuticals Inc. (THLD) (IPO; co-lead)

2/4/05

$7

$14.45

$37.3

+106%

Citigroup

Martek Biosciences Corp. (MATK) (co-lead)

1/21/05

$49.10

$24.60

$86.3

-50%

Credit Suisse First Boston

Anadys Pharmaceuticals Inc. (ANDS)(co-lead)

8/4/05

$12.40

$8.80

$71.3

-29%

Rigel Pharmaceuticals Inc. (RIGL) (co-lead)

7/15/05

$20.75

$8.36

$87.1

-60%

ViaCell Inc. (VIAC) (IPO; co-lead)

1/21/05

$7

$5.62

$60.38

-20%

D.A. Davidson & Co.

Martek Biosciences Corp. (MATK)

1/21/05

$49.10

$24.60

$86.3

-50%

Delafield Hambrecht

Nastech Pharmaceutical Co. Inc.(NSTK)

8/25/05

$13.50

$14.72

$23.3

+9%

Desjardins
Securities

Neurochem Inc. (NRMX)

3/4/05

$15.30

$14.22

$61.2

-7%

Deutsche Bank
Securities

Momenta Pharmaceuticals Inc.(MNTA) (co-lead)

7/21/05

$27.02

$22.04

$130.4

-18%

Nuvelo Inc. (NUVO) (co-lead)

2/2/05

$7.50

$8.11

$73.31

+8%

Senomyx Inc. (SNMX) (lead)

11/4/05

$14.60

$12.12

$59

-20%

XenoPort Inc. (XNPT) (IPO; co-lead)

6/2/05

$10.50

$17.95

$52.5

+71%

Ferris, Baker Watts

BioDelivery Sciences International Inc. (BDSI) (lead)

9/30/05

$2

$2.48

$8.8

+24%

First Albany
Capital

CV Therapeutics Inc. (CVTX)

6/29/05

$21.60

$24.73

$180.4

+14%

Martek Biosciences Corp. (MATK)

1/21/05

$49.10

$24.60

$86.3

-50%

Myogen Inc. (MYOG)

9/16/05

$23.25

$30.10

$125

+29%

Myriad Genetics Inc. (MYGN)

11/3/05

$18.50

$20.80

$148.9

+12%

First Associates
Investments

Cardiome Pharma Corp. (CRME)

3/18/05

$6

$10.10

$58.65

+68%

First Dunbar
Securities

CardioVascular BioTherapeutics Inc. (OTC BB:CVBT) (IPO; lead)

3/14/05

$10

$4.55

$17.25

-55%

Friedman, Billings,
Ramsey

Bioenvision Inc. (BIVN)

2/3/05

$8

$6.53

$60

-18%

Tercica Inc. (TRCA)

2/8/05

$8

$7.17

$55.2

-10%

Fortis Securities

Neurochem Inc. (NRMX)

3/4/05

$15.30

$14.22

$61.2

-7%

GMP Securities

Cardiome Pharma Corp. (CRME)

3/18/05

$6

$10.10

$58.65

+68%

Goldman, Sachs
& Co.

Amylin Pharmaceuticals Inc. (AMLN)(lead)

8/30/05

$31

$39.92

$157.1

+29%

Amylin Pharmaceuticals Inc. (AMLN)(co-lead)

1/21/05

$22

$39.92

$202.4

+81%

Digene Corp. (DIGE)

11/16/05

$28

$29.17

$64.4

+4%

Exelixis Inc. (EXEL) (lead)

8/17/05

$7.75

$9.42

$50.4

+35%

Myogen Inc. (MYOG) (lead)

9/16/05

$23.25

$30.10

$125

+29%

Renovis Inc. (RNVS) (lead)

9/23/05

$13.50

$15.30

$54

+13%

ViroPharma Inc. (VPHM) (co-lead)

12/7/05

$16.75

$18.50

$173.4

+10%

Granite Financial
Group

Arena Pharmaceuticals Inc. (ARNA)

2/1/05

$6

$14.21

$51.75

+137%

GunnAllen
Financial

Accentia Biopharmaceuticals Inc. (ABPI) (IPO)

10/28/05

$8

$5.05

$19.2

-37%

GunnAllen
Financial

BioDelivery Sciences International Inc. (BDSI)

9/30/05

$2

$2.48

$8.8

+24%

Harris Nesbitt

Northfield Laboratories Inc. (NFLD)

2/4/05

$15

$13.40

$77.63

-11%

Tercica Inc.
(TRCA)

2/8/05

$8

$7.17

$55.2

-10%

Jefferies & Co.

Accentia Biopharmaceuticals Inc. (ABPI) (IPO; lead)

10/28/05

$8

$5.05

$19.2

-37%

Keryx Biopharmaceuticals Inc. (KERX)

7/15/05

$14.05

$14.64

$81.2

+4%

Neose Technologies Inc. (NTEC)

2/18/05

$4

$1.94

$32.2

-52%

JMP Securities

Dendreon Corp. (DNDN)

12/7/05

$4.50

$5.42

$51.8

+20%

Genomic Health Inc. (GHDX) (IPO)

9/29/05

$12

$9.11

$60.2

-24%

Myriad Genetics Inc. (MYGN)

11/3/05

$18.50

$20.80

$148.9

+12%

JP Morgan
Securities

Amylin Pharmaceuticals Inc. (AMLN)

1/21/05

$22

$39.92

$202.4

+81%

Barrier Therapeutics Inc. (BTRX)

2/10/05

$19.50

$8.20

$39

-58%

Bioenvision Inc. (BIVN) (co-lead)

2/3/05

$8

$6.53

$60

-18%

Coley Pharmaceutical Group Inc. (COLY) (IPO; co-lead)

8/10/05

$16

$15.16

$110.4

-5%

Digene Corp. (DIGE) (co-lead)

11/16/05

$28

$29.17

$64.4

+4%

JP Morgan
Securities

Durect Corp. (DRRX) (co-lead)

11/2/05

$5

$5.07

$41.1

+1%

Genomic Health Inc. (GHDX) (IPO; co-lead)

9/29/05

$12

$9.11

$60.2

-24%

Icagen Inc. (ICGN) (IPO; co-lead)

2/3/05

$8

$6.45

$40.8

-19%

Keryx Biopharmaceuticals Inc. (KERX) (co-lead)

7/15/05

$14.05

$14.64

$81.2

+4%

Myriad Genetics Inc. (MYGN) (co- lead)

11/3/05

$18.50

$20.80

$148.9

+12%

Neose Technologies Inc. (NTEC)

2/18/05

$4

$1.94

$32.2

-52%

Somaxon Pharmaceuticals Inc. (SOMX) (IPO; co-lead)

12/15/05

$11

$9.95

$55

-10%

Telik Inc. (TELK)

1/28/05

$18.75

$16.99

$151

-9%

Vertex Pharmaceuticals Inc. (VRTX)

6/7/05

$13

$27.67

$175.6

+113%

Lazard Capital
Markets

Ariad Pharmaceuticals Inc. (ARIA)

8/5/05

$7.20

$5.85

$62.1

-19%

Coley Pharmaceutical Group Inc. (COLY) (IPO)

8/10/05

$16

$15.16

$110.4

-5%

CombinatoRx Inc. (CRXX) (IPO)

11/9/05

$7

$8.18

$48.3

+17%

Dendreon Corp. (DNDN)

12/7/05

$4.50

$5.42

$51.8

+20%

Geron Corp. (GERN)

9/16/05

$9

$8.61

$62.1

-4%

Lazard Capital
Markets

GTx Inc. (GTXI) (co-lead)

10/11/05

$7.80

$7.56

$49.3

-3%

ISTA Pharmaceuticals Inc. (ISTA)

1/20/05

$8.88

$6.36

$56.2

-28%

Myogen Inc. (MYOG)

9/16/05

$23.25

$30.10

$125

+29%

OxiGene Inc. (OXGN) (co-lead)

12/15/05

$3.65

$3.97

$27.3

+9%

Threshold Pharmaceuticals Inc. (THLD) (IPO)

2/4/05

$7

$14.45

$37.3

+106%

ViaCell Inc. (VIAC) (IPO)

1/21/05

$7

$5.62

$60.38

-20%

ViroPharma Inc. (VPHM)

12/7/05

$16.75

$18.50

$173.4

+10%

XenoPort Inc. (XNPT) (IPO)

6/2/05

$10.50

$17.95

$52.5

+71%

Leerink Swann
& Co.

Cardiome Pharma Corp. (CRME)

3/18/05

$6

$10.10

$58.65

+68%

Coley Pharmaceutical Group Inc. (COLY) (IPO)

8/10/05

$16

$15.16

$110.4

-5%

Panacos Pharmaceuticals Inc. (PANC)

10/6/05

$10.50

$6.93

$86.6

-34%

ViaCell Inc. (VIAC) (IPO)

1/21/05

$7

$5.62

$60.38

-20%

Legg Mason
Wood Walker

Avalon Pharmaceuticals Inc. (AVRX)(IPO)

9/29/05

$10.50

$4.50

$28.9

-57%

Lehman Brothers

Ariad Pharmaceuticals Inc. (ARIA) (lead)

8/5/05

$7.20

$5.85

$62.1

-19%

CV Therapeutics Inc. (CVTX) (co-lead)

6/29/05

$21.60

$24.73

$180.4

+14%

Lehman Brothers

Genomic Health Inc. (GHDX) (IPO; co-lead)

9/29/05

$12

$9.11

$60.2

-24%

Rigel Pharmaceuticals Inc. (RIGL) (co-lead)

7/15/05

$20.75

$8.36

$87.1

-60%

Sunesis Pharmaceuticals Inc. (SNSS)(IPO; co-lead)

9/26/05

$7

$4.98

$42

-29%

Telik Inc. (TELK)

1/28/05

$18.75

$16.99

$151

-9%

Tercica Inc. (TRCA) (co-lead)

2/8/05

$8

$7.17

$55.2

-10%

Maxim Group

BioDelivery Sciences International Inc. (BDSI)

9/30/05

$2

$2.48

$8.8

+24%

Merrill Lynch & Co.

Aspreva Pharmaceuticals Corp. (ASPV) (IPO; co-lead)

3/3/05

$11

$15.72

$91.1

+43%

BioMarin Pharmaceutical Inc. (BMRN) (lead)

7/14/05

$7.05

$10.78

$59.9

+53%

Coley Pharmaceutical Group Inc. (COLY) (IPO; co-lead)

8/10/05

$16

$15.16

$110.4

-5%

CV Therapeutics Inc. (CVTX) (co-lead)

6/29/05

$21.60

$24.73

$180.4

+14%

Onyx Pharmaceuticals Inc. (ONXX) (co-lead)

11/18/05

$25.25

$28.80

$126.3

+14%

Vertex Pharmaceuticals Inc. (VRTX) (lead)

6/7/05

$13

$27.67

$175.6

+113%

ZymoGenetics Inc. (ZGEN) (lead)

8/4/05

$18

$17.01

$135

-6%

Merriman Curhan Ford & Co.

Advanced Life Sciences Holdings Inc. (ADLS) (IPO)

8/4/05

$5

$3.92

$32

-22%

Morgan Joseph & Co.

Arena Pharmaceuticals Inc. (ARNA)

2/1/05

$6

$14.21

$51.75

+137%

Morgan Stanley & Co.

Alexion Pharmaceuticals Inc. (ALXN) (lead)

8/12/05

$26.75

$20.25

$66.9

-24%

Amylin Pharmaceuticals Inc. (AMLN) (co-lead)

1/21/05

$22

$39.92

$202.4

+78%

Barrier Therapeutics Inc. (BTRX)(lead)

2/10/05

$19.50

$8.20

$39

-58%

Durect Corp. (DRRX) (co-lead)

11/2/05

$5

$5.07

$41.1

+1%

Idenix Pharmaceuticals Inc. (IDIX) (co-lead)

10/26/05

$20.61

$17.11

$150

-17%

Momenta Pharmaceuticals Inc. (MNTA) (co-lead)

7/21/05

$27.02

$22.04

$130.4

-18%

Onyx Pharmaceuticals Inc. (ONXX)(co-lead)

11/18/05

$25.25

$28.80

$126.3

+14%

Somaxon Pharmaceuticals Inc. (SOMX) (IPO; co-lead)

12/15/05

$11

$9.95

$55

-10%

Threshold Pharmaceuticals Inc. (THLD) (lead)

10/12/05

$10.46

$14.45

$65.4

+38%

XenoPort Inc. (XNPT) (IPO; co-lead)

6/2/05

$10.50

$17.95

$52.5

+71%

Needham & Co.

Anadys Pharmaceuticals Inc. (ANDS)

8/4/05

$12.40

$8.80

$71.3

-29%

Needham & Co.

Arena Pharmaceuticals Inc. (ARNA)

2/1/05

$6

$14.21

$51.75

+137%

CoTherix Inc. (CTRX)

10/6/05

$13

$10.58

$56.4

-19%

CoTherix Inc. (CTRX)

2/10/05

$8.90

$10.58

$37.83

+19%

Favrille Inc. (FVRL) (IPO)

2/2/05

$7

$4.05

$42

-42%

Geron Corp. (GERN)

9/16/05

$9

$8.61

$62.1

-4%

Martek Biosciences Corp. (MATK)

1/21/05

$49.10

$24.60

$86.3

-50%

Nastech Pharmaceutical Co. Inc. (NSTK) (lead)

8/25/05

$13.50

$14.72

$23.3

+9%

Nuvelo Inc. (NUVO)

2/2/05

$7.50

$8.11

$73.31

+8%

Panacos Pharmaceuticals Inc. (PANC)

10/6/05

$10.50

$6.93

$86.6

-34%

Sunesis Pharmaceuticals Inc. (SNSS) (IPO)

9/26/05

$7

$4.98

$42

-29%

Nicolaus & Co.

Accentia Biopharmaceuticals Inc. (ABPI) (IPO)

10/28/05

$8

$5.05

$19.2

-37%

Oppenheimer & Co.

Keryx Biopharmaceuticals Inc. (KERX)

7/15/05

$14.05

$14.64

$81.2

+4%

Orion Securities

Cardiome Pharma Corp. (CRME)

3/18/05

$6

$10.10

$58.65

+68%

Pacific Growth Equities

Aspreva Pharmaceuticals Corp.(ASPV) (IPO)

3/3/05

$11

$15.72

$91.1

+43%

Pacific Growth Equities

Barrier Therapeutics Inc. (BTRX)

2/10/05

$19.50

$8.20

$39

-58%

CombinatoRx Inc. (CRXX) (IPO; co-lead)

11/9/05

$7

$8.18

$48.3

+17%

Dynavax Technologies Inc. (DVAX)

10/11/05

$6.25

$4.21

$35.75

-33%

La Jolla Pharmaceutical Co. (LJPC) (lead)

1/28/05

$7

$3.70

$17.2

-47%

Point Therapeutics Inc. (POTP) (co-lead)

11/22/05

$3

$3.45

$27.8

+15%

XenoPort Inc. (XNPT) (IPO)

6/2/05

$10.50

$17.95

$52.5

+71%

ZymoGenetics Inc. (ZGEN)

8/4/05

$18

$17.01

$135

-6%

Piper Jaffray & Co.

Acusphere Inc. (ACUS) (lead)

9/23/05

$5.25

$5.34

$18.7

+1%

Anadys Pharmaceuticals Inc. (ANDS)

8/4/05

$12.40

$8.80

$71.3

-29%

Arena Pharmaceuticals Inc. (ARNA)(co-lead)

2/1/05

$6

$14.21

$51.75

+137%

CoTherix Inc. (CTRX)

10/6/05

$13

$10.58

$56.4

-19%

CoTherix Inc. (CTRX) (co-lead)

2/10/05

$8.90

$10.58

$37.83

+19%

CV Therapeutics Inc. (CVTX)

6/29/05

$21.60

$24.73

$180.4

+14%

Genomic Health Inc. (GHDX) (IPO)

9/29/05

$12

$9.11

$60.2

-24%

Myriad Genetics Inc. (MYGN)

11/3/05

$18.50

$20.80

$148.9

+12%

Piper Jaffray & Co.

Neurochem Inc. (NRMX)

3/4/05

$15.30

$14.22

$61.2

-7%

Renovis Inc. (RNVS)

9/23/05

$13.50

$15.30

$54

+13%

Somaxon Pharmaceuticals Inc.(SOMX) (IPO)

12/15/05

$11

$9.95

$55

-10%

ViroPharma Inc. (VPHM) (co-lead)

12/7/05

$16.75

$18.50

$173.4

+10%

ZymoGenetics Inc. (ZGEN)

8/4/05

$18

$17.01

$135

-6%

Punk, Ziegel & Co.

Keryx Biopharmaceuticals Inc. (KERX)

7/15/05

$14.05

$14.64

$81.2

+4%

Zonagen Inc. (ZONA) (co-lead)

1/27/05

$4

$5.11

$20.2

+28%

Robert W. Baird & Co.

Meridian Bioscience Inc. (VIVO) (lead)

9/16/05

$17.50

$20.14

$31.5

+15%

Tercica Inc. (TRCA)

2/8/05

$8

$7.17

$55.2

-10%

Rodman & Renshaw

Geron Corp. (GERN)

9/16/05

$9

$8.61

$62.1

-4%

SG Cowen & Co.

Anadys Pharmaceuticals Inc. (ANDS) (co-lead)

8/4/05

$12.40

$8.80

$71.3

-29%

Ariad Pharmaceuticals Inc. (ARIA)

8/5/05

$7.20

$5.85

$62.1

-19%

CombinatoRx Inc. (CRXX) (IPO; co-lead)

11/9/05

$7

$8.18

$48.3

+17%

CV Therapeutics Inc. (CVTX)

6/29/05

$21.60

$24.73

$180.4

+14%

Digene Corp. (DIGE)

11/16/05

$28

$29.17

$64.4

+4%

Geron Corp. (GERN)

9/16/05

$9

$8.61

$62.1

-4%

SG Cowen & Co.

GTx Inc. (GTXI) (co-lead)

10/11/05

$7.80

$7.56

$49.3

-3%

Momenta Pharmaceuticals Inc. (MNTA)

7/21/05

$27.02

$22.04

$130.4

-18%

Northfield Laboratories Inc. (NFLD)(co-lead)

2/4/05

$15

$13.40

$77.63

-11%

OxiGene Inc. (OXGN) (co-lead)

12/15/05

$3.65

$3.97

$27.3

+9%

Panacos Pharmaceuticals Inc. (PANC) (co-lead)

10/6/05

$10.50

$6.93

$86.6

-34%

Renovis Inc. (RNVS)

9/23/05

$13.50

$15.30

$54

+13%

Sunesis Pharmaceuticals Inc. (SNSS) (IPO; co-lead)

9/26/05

$7

$4.98

$42

-29%

Tercica Inc. (TRCA) (co-lead)

2/8/05

$8

$7.17

$55.2

-10%

ViroPharma Inc. (VPHM)

12/7/05

$16.75

$18.50

$173.4

+10%

Vivus Inc. (VVUS) (co-lead)

3/10/05

$3.40

$2.96

$21.25

-13%

SunTrust Robinson, Humphrey

Nastech Pharmaceutical Co. Inc. (NSTK)

8/25/05

$13.50

$14.72

$23.3

+9%

Susquehanna Financial

Avalon Pharmaceuticals Inc. (AVRX) (IPO)

9/29/05

$10.50

$4.50

$28.9

-57%

ThinkEquity Partners

Advanced Life Sciences Holdings Inc. (ADLS) (IPO; co-lead)

8/4/05

$5

$3.92

$32

-22%

Thomas Weisel Partners

CoTherix Inc. (CTRX)

2/10/05

$8.90

$10.58

$37.83

+19%

Digene Corp. (DIGE) (co-lead)

11/16/05

$28

$29.17

$64.4

+4%

Thomas Weisel Partners

Genomic Health Inc. (GHDX) (IPO)

9/29/05

$12

$9.11

$60.2

-24%

ISTA Pharmaceuticals Inc. (ISTA)(co-lead)

1/20/05

$8.88

$6.36

$56.2

-28%

SeraCare Life Sciences Inc. (SRLS)

5/25/05

$12.25

$8.87

$42.6

-28%

Somaxon Pharmaceuticals Inc. (SOMX) (IPO)

12/15/05

$11

$9.95

$55

-10%

UBS Investment Bank

Bioenvision Inc. (BIVN) (co-lead)

2/3/05

$8

$6.53

$60

-18%

Cardiome Pharma Corp. (CRME) (co-lead)

3/18/05

$6

$10.10

$58.65

+68%

CoTherix Inc. (CTRX) (co-lead)

10/6/05

$13

$10.58

$56.4

-19%

Geron Corp. (GERN) (lead)

9/16/05

$9

$8.61

$62.1

-4%

Icagen Inc. (ICGN) (IPO; co-lead)

2/3/05

$8

$6.45

$40.8

-19%

Myriad Genetics Inc. (MYGN) (co-lead)

11/3/05

$18.50

$20.80

$148.9

+12%

Neose Technologies Inc. (NTEC) (lead)

2/18/05

$4

$1.94

$32.20

-52%

Neurochem Inc. (NRMX) (lead)

3/4/05

$15.30

$14.22

$61.20

-7%

Northfield Laboratories Inc. (NFLD) (co-lead)

2/4/05

$15

$13.40

$77.63

-11%

Nuvelo Inc. (NUVO) (co-lead)

2/2/05

$7.50

$8.11

$73.31

+8%

Progenics Pharmaceuticals

Inc. (PGNX) (co-lead)

9/14/05

$23.90

$25.01

$59.75

+5%

UBS Investment Bank

Progenics Pharmaceuticals Inc. (PGNX) (lead)

6/10/05

$19.25

$25.01

$29.50

+30%

Progenics Pharmaceuticals Inc. (PGNX) (co-lead)

4/1/05

$15.25

$25.01

$30.50

+64%

Telik Inc. (TELK) (lead)

1/28/05

$18.75

$16.99

$151

-9%

Vertex Pharmaceuticals Inc. (VRTX)

6/7/05

$13

$27.67

$175.6

+113%

ViaCell Inc. (VIAC) (IPO; co-lead)

1/21/05

$7

$5.62

$60.38

-20%

Wachovia Capital Markets

Amylin Pharmaceuticals Inc. (AMLN)

1/21/05

$22

$39.92

$202.4

+81%

Vivus Inc. (VVUS) (co-lead)

3/10/05

$3.40

$2.94

$21.25

-13%

WBB Securities

Geron Corp. (GERN)

9/16/05

$9

$8.61

$62.1

-4%

Wells Fargo Securities

Neurochem Inc. (NRMX)

3/4/05

$15.30

$14.22

$61.2

-7%

William Blair & Co.

SeraCare Life Sciences Inc. (SRLS)

5/25/05

$12.25

$8.87

$42.6

-28%

Threshold Pharmaceuticals Inc. (THLD) (IPO)

2/4/05

$7

$14.45

$37.3

+106%

WR Hambrecht + Co.

Avalon Pharmaceuticals Inc. (AVRX)(IPO; lead)

9/29/05

$10.50

$4.50

$28.9

-57%

Durect Corp. (DRRX) (co-lead)

11/2/05

$5

$5.07

$41.1

+1%

Zonagen Inc. (ZONA) (co-lead)

1/27/05

$4

$5.11

$20.2

+28%

Notes:

* The financings in this chart include only public offerings of stock in the U.S. The data were compiled primarily from BioWorld Financial Watch's monthly financing charts covering the period from Jan. 1 to Dec. 31, 2005. The gross proceed totals include money raised through overallotment options. Offering prices were adjusted to reflect stock splits, where applicable.

Unless otherwise noted, shares are traded on the Nasdaq exchange.

OTC BB = Over-the-Counter Bulletin Board.

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