March 7 & 14 (EP), March 1 & 8 (WO)

Absorber WO 01/13947

Reducing xenotransplant immunogenicity

Huddinge, Sweden

Reduction of xenotransplant tissue immunogenicity by removing macrophages and microglial cells and antigens.

Academic Med. Ctr. EP 1 083 230

Inducible viral replicons

Amsterdam, Netherlands

Inducible viral replicons for use in live-attenuated HIV vaccines.

Active Biotech WO 01/14884

Melanoma antigen

Lund, Sweden

Melanoma-associated antigen expressed on cell surfaces, antibodies; for diagnostics and therapeutics.

ActivePass Pharma WO 01/14414 & 14547

ABC transporter

Vancouver, B.C.

ABC transporter, encoding gene sequences, fusions, antigenic peptides, antibodies; for developing therapeutics.

Adv. Res. & Technol. Inst. WO 01/14418

Cell cycle regulatory protein

Indianapolis

Cell cycle regulatory protein p193, encoding gene sequences; for developing apoptosis modulators.

Allergan Sales WO 01/14570

Activatable neurotoxins

Irvine, Calif.

Activatable recombinant neurotoxins, encoded proteins, production methods; for therapeutics.

Ambergen WO 01/14578

Nascent protein detection

Boston

Boron-containing dyes for marking nascent proteins; for detection in cell-free protein synthesis systems.

Amersham Pharmacia Biotech WO 01/14568

Mutant Taq DNA polymerases

Piscataway, N.J.

Mutant thermostable Taq DNA polymerases having improved salt tolerance, encoding gene sequences; for PCR-based methods.

Asahi EP 1 083 226

Hematopoietic cell separation

Osaka, Japan

Device and methods for separating cluster differentiation-positive undifferentiated human hematopoietic cells.

AstraZeneca WO 01/14533

Antifungal screens

London

Yeast phosphomevalonate kinase gene, encoded protein, production methods; for antifungal screens.

Atlantic Biopharma WO 01/15709

Modulating apoptosis

Cambridge, Mass.

Administration of a-feta protein or an apoptosis-inhibiting fragment; for modulating apoptosis

Babraham Inst. WO 01/13715

Schizophrenia model

Babraham, UK

Animals having a manipulated vesicular monoamine transporter gene; for studying schizophrenia and other neural diseases.

Biocrystal WO 01/13945

Multiple sclerosis therapy

Westerville, Ohio

Affinity ligands that bind to B-cell determinants and reduce B-cell numbers; for multiple sclerosis therapy.

Biocrystal WO 01/14846 & 14881

Multiple sclerosis immunoresponse

Westerville, Ohio

Measurement and comparison of B-cell subpopulations; for detecting a multiple sclerosis immunoresponse.

Biofrontera Pharma EP 1 081 225 & WO 01/16176

Parkinson's transgenics

Leverkusen, Germany

Transgenics having an inserted parkin2 gene with mutations characteristic of Parkinson's; for disease modeling.

BioMerieux WO 01/14586

Biochip measurement analysis

Marcy l'Etoile, France

Analyzing measurements obtained from a biochip by quantifying hybridization rates of various probes.

Brussells, Univ. of EP 1 083 227

Inducible gene therapy vector

Brussells, Belgium

Antibiotic modulatable vectors containing therapeutic genes; for gene therapy and immunization.

Cancer Translational Res. Ctr. WO 01/14546

Cancer transcription modulator

Montreal

Replication protein A binding transcriptional factor, encoding gene; for developing cancer therapeutics.

Case Western Res. Univ. WO 01/14403

Potassium channel modulation

Cleveland

MinK2 protein, encoding gene sequences; for potassium channel modulator screens.

Chiron WO 01/14415

EGFH2 genes

Emeryville, Calif.

EGFH2 genes, encoded proteins, variants; for developing therapeutics.

Chugai EP 1 081 224

Membrane-bound protein genes

Tokyo

Methods for selectively isolating genes encoding membrane-bound proteins.

Chugai WO 01/13940

Myeloma cell antigen expression potentiators

Tokyo

Potentiators for the expression of HM1.24 antigen in myeloma cells that are derived form various interferons.

Chugai WO 01/14551

Cartilage differentiating factors

Tokyo

Transcription factor from the family of factors induced by differentiating cartilage cells; for making therapeutics.

Clarity Biosciences WO 01/14592

Intron SNPs for identification

San Diego

Identifying organisms by detecting distinctive intronic nucleic acid sequence polymorphisms.

CuraGen WO 01/14564

T cell-expressed genes

New Haven, Conn.

Gene sequences expressed in activated T cells, encoded proteins, variants, fragments; for developing therapeutics.

Dana-Farber Cancer Inst. WO 01/14556 & 14557

B7-4 protein

Boston

B7-4 protein and its receptor PD-1, encoding genes; for developing immune cell activation modulators.

DeCode Genetics WO 01/14555

Narcolepsy gene

Reykjavik, Iceland

Human narcolepsy-associated gene, encoded hypocretin receptor 1; for developing diagnostics and therapeutics.

DNAChip WO 01/14425

Protein chips

Seoul, S. Korea

Protein chips on which a high density of probe arrays can be fixed; for diagnostics.

Erasmus Univ. EP 1 081 227

Tranfecting CD34+ cells

Rotterdam, Netherlands

Gene delivery methods and vehicles for transfecting CD34+ cells; for gene therapy.

European Lab Molec. Biol. WO 01/14585

Immobilizing nucleic acids

Heidelberg, Germany

Covalent immobilization of nucleic acids on a solid phase; for marking and purification.

Fibrogen WO 01/15729

Connective tissue growth factor receptor

S. San Francisco

Connective tissue growth factor receptor, encoding gene sequences, modulators; for diagnostics and therapeutics.

Fox, J.S. WO 01/14591

Biomolecule detection

Encinitas, Calif.

High-sensitivity detection and manipulation of biomolecules using magnetic particles.

Genaissance Pharma WO 01/14588

IgE receptor gene SNPs

New Haven, Conn.

Identifying polymorphisms in the immunoglobulin E receptor _ chain gene; for finding drug target isogenes.

Genencor Intl. WO 01/15521

Donor-specific immunity transgenics

Palo Alto, Calif.

Transgenics capable of facilitating production of donor-specific functional immunity.

Genentech WO 01/15730

ErbB2 antibody therapy

S. San Francisco

Administration of anti-ErbB2 antibodies for disorders characterized by ErbB2 overexpression; for cancer therapy.

Genesis Res. & Develop. WO 01/14553

Mammary gland genes

Purnell, Australia

Mammary gland gene sequences, encoded proteins; for developing diagnostics and therapeutics.

Genome Therapeutics WO 01/14542

Apoptosis inducer assay

Waltham, Mass.

Death-domain transmembrane proteins having heterologous membrane spanning domains; for finding apoptosis inducers.

Genset WO 01/14550

Prostate cancer-related gene

Paris

Prostate cancer-related gene 3, biallelic markers, antibodies; for diagnostics and therapeutics.

HSP Res. Inst. EP 1 081 231

Recovering soluble protein

Osaka, Japan

Methods for preventing aggregation and recovering soluble protein in recombinant production systems.

Human Genome Sciences WO 01/14545

PGRP-L polypeptides

Rockville, Md.

PGRP-L polypeptides, encoding gene sequences, antibodies, production methods; for diagnostics and therapeutics.

Immunex WO 01/14529

Enhanced protein production

Seattle

Modulating the IGF-1 signaling pathway in cultured cells to enhance improved recombinant protein production.

Immunobiology WO 01/13943

Intracellular pathogen vaccines

Babraham, UK

Isolating heat shock proteins induced by heat or TNF treatment in cells infected by intracellular pathogens.

Immunobiology WO 01/13944

Extracellular pathogen vaccines

Babraham, UK

Isolating heat shock proteins induced by heat or TNF treatment in cells infected by extracellular pathogens.

Imperial Cancer Res. Technol. WO 01/14413

Smad-interacting polypeptides

London

Polypeptides that can interact with Smad; for assays to screen potential therapeutics.

Inoue, K., et al. WO 01/13716

Vitamin E deficiency model

Tokyo

Knockout animals having a modified a-tocopherol transport protein gene; for developing oxidative stress therapeutics.

Introgene EP 1 083 228

Adenoviral gene therapy vectors

Leiden, Netherlands

Adenoviral vectors lacking E1A and E1B gene sequences and having reduced E2B and E4 gene expression; for gene therapy.

Introgene EP 1 083 231

Smooth muscle cell promoter

Leiden, Netherlands

Smooth muscle cell-specific gene promoters; for use in adenoviral gene therapy vectors.

Isis Pharma WO 01/14402

FAK antisense

Carlsbad, Calif.

Antisense to the focal adhesion kinase encoding gene; for disease-related expression modulation.

Isis Pharma WO 01/15739

Rho family gene antisense

Carlsbad, Calif.

Antisense to Rho family genes that express low-molecular-weight GTPases; for hyperproliferative disorders.

Janssen Pharma WO 01/14549

Conditional cell death

Beerse, Belgium

Conditional cell death system based on apoptosis gene promoter controlled heterologous gene expression.

Johns Hopkins Univ. WO 01/14539

Nucleic acid fusion libraries

Baltimore

Nucleic acid fusion libraries in which members have nucleic acid modification and enzyme attachment sequence domains.

Jung, G., et al. Ep 1 083 232

mRNA transfer

Tubingen, Germany

Methods for transferring mRNA into cells by using polycationic peptide compounds.

Kirin WO 01/14522

Yeast production system

Tokyo

Yeast strains that can produce glycoproteins with mammalian type sugar chains; for heterologous protein production.

Kurokawa, K. WO 01/14552

Mesangial cell protein

Tokyo

Mesangial cell protein MEG-1, encoding gene sequences; for developing diagnostics and therapeutics.

Kyowa Medex EP 1 083 428

Detecting HCV core antigens

Tokyo

Detecting human cytomegalovirus core antigens by using specific antibodies.

Leadd EP 1 081 226, 1 083 224, & WO 01/16165

Apoptin-associating protein

Leiden, Netherlands

Apoptin-associating protein; for developing therapeutics for cells in which p53 is at least partially nonfunctional.

Lexicon Genetics WO 01/14422

Mammary gland cDNA

The Woodlands, Texas

Gene sequence derived from a mammary gland cDNA library; for developing diagnostics and therapeutics.

Lin, S.L. WO 01/13959

Gene function knockout methods

Alhambra, Calif.

Methods for gene function knockout by covalently binding antisense probes to gene transcripts.

Luminex WO 01/14589

Liquid nucleic acid arrays

Austin, Texas

Quantitating nucleic acids using oligo probes coupled to fluorescently addressable multicolored microparticles.

Mass. Gen. Hosp. WO 01/13948

Sepsis therapeutics targets

Boston

Outer membrane protein A, peptidolycan-associated lipoprotein, and murein lipoprotein as sepsis targets.

Maxygen WO 01/15736

Interferon-_ like molecules

Horsholm, Denmark

Non-polypeptide moiety linked to a mutant interferon-_; for immunotherapy.

Medarex WO 01/14424

Human CTLA-4 antibodies

Annandale, N.J.

Human CTLA-4 antibodies; for treating various diseases including infections.

MedImmune WO 01/14421

Streptococcus vaccines

Gaithersburg, Md.

Homologs of Streptococcus pneumoniae Sp36 protein, encoding genes, fragments; for developing vaccines.

Merck WO 01/14416

Synthetic papillomavirus genes

Rahway, N.J.

Synthetic DNA molecules encoding human papillomavirus proteins; for developing vaccines.

Merck WO 01/14548

G-protein coupled receptor

Darmstadt, Germany

G-protein coupled receptor, encoding gene sequences, production methods; for developing therapeutics.

Michigan, Univ. of WO 01/15731

C5A antibodies for sepsis

Ann Arbor, Mich.

Methods and compositions for treating sepsis by using C5A antibodies and C-terminal truncations.

MorphoSys WO 01/14558

Histocompatibility antibodies

Martinsried, Germany

Human antibodies to histocompatibility antigen HLA-Cw6, encoding gene sequences, fragments; for therapeutics.

Ortho-McNeil Pharma WO 01/15520

PA28-modified transgenics

Raritan, N.J.

Transgenics having a modified PA28 gene and thus producing inactivated PA28, derived cells and cell lines.

Pharmacia & Upjohn WO 01/14544

Transcription factor assay

Stockholm, Sweden

Nucleotide sequence having a binding site for the human fork head transcription factor Afx; for modulator screens.

Pharmacia & Upjohn WO 01/14554

G protein-coupled receptor

Kalamazoo, Mich.

G protein-coupled receptor expressed in brain, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Pharmacia & Upjohn WO 01/14584

Papillomavirus antivirals

Kalamazoo, Mich.

Identifying specific inhibitors of human papillomavirus E7 binding to the CDK2 complex; for designing antivirals.

Pittsburgh, Univ. of WO 01/13960

Cartilage gene therapy

Pittsburgh, Penn.

Transfection of subchondral cells in a joint in vivo; for gene therapy.

Pittsburgh, Univ. of WO 01/15511

Nuclear transport facilitating peptides

Pittsburgh, Penn.

Identification of internalizing peptides that facilitate the cytoplasmic uptake and nuclear transport of proteins.

Promega WO 01/14590

DNA isolation and sequencing

Madison, Wis.

Simultaneous isolation and quantitation of DNA by amplification, short tandem repeat analysis, and sequencing.

Ramot Univ. WO 01/15655

Neurodegeneration therapeutics

Tel Aviv, Israel

Antibodies to peptides involved in neurodegenerative diseases; for diagnostics and therapeutics.

Sembiosys Genetics WO 01/14571

Chymosin from plants

Calgary, Alberta

Commercial production of chymosin in plants using recombinant expression methods.

SmithKline Beecham WO 01/14409

Antibacterial screens

Philadelphia

Bacterial deoxyxylulose-5-phosphate synthase, encoding gene, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 01/14410

7-transmembrane receptor

Philadelphia

PAFR-line 7-transmembrane receptor, encoding gene, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 01/14423

Calcium channel proteins

Brentford, UK

Calcium channel proteins, encoding genes, production methods; for developing diagnostics and therapeutics.

SmithKline Beecham WO 01/14523, 16173 & 16351

Antibacterial screens

Philadelphia

Bacterial tktA, fabF, and dnaE polypeptides, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 01/14577

Galanin-like receptor

Philadelphia

Galanin-like 7-transmembrane receptor, encoding gene, recombinant production methods; for therapeutics.

Subsidiary No. 3 WO 01/15741, 16322 & 16323

HIV suppressor elements

Wilmington, N.C.

Genetic elements and corresponding cellular genes that suppress HIV activities, identification of such sequences.

Sumitomo Pharma WO 01/14582

ER protein gene transfection

Osaka, Japan

Transfecting genes encoding endoplasmic reticulum membrane proteins that participate in protein transport.

Takeda Chemical EP 1 081 222

19P2 ligand antibodies

Osaka, Japan

Anti-19P2 ligand monoclonal antibodies; for neutralizing the arachidonic acid releasing activity of the 19P2 ligand.

Takeda Chemical EP 1 083 223

Immortalized liver cell line

Osaka, Japan

Immortalized human liver cell line derived from fetal tissue; for studying metabolism.

Texas, Univ. of WO 01/14581

Treating cardiac hypertrophy

Austin, Texas

Modulation of HDAC4/5 regulation of cardiac gene expression; for treating cardiac hypertrophy.

Texas Biotech WO 01/14404

Junctional adhesion protein gene

Houston

Gene sequences encoding a human junctional adhesion protein, encoded protein; for developing therapeutics.

Torino, Univ. of WO 01/14420

Plexins

Candiolo, Italy

Plexin neuropilin multimeric receptor complexes for semaphorins, encoding genes; for treating neural diseases.

University Health Network WO 01/15728

Activating cytotoxic T cells

Toronto

Activating cytotoxic T cells using CD40 antibodies and an antigen; for destroying antigen-presenting cells.

Urogene WO 01/13714

Prostate cancer cells

Evry, France

Prostate cancer cell line; for inducing cancer in an animal model and generating diagnostics antibodies.

Valigen WO 01/15740

Single-stranded mutational vectors

Newtown, Penn.

Single-stranded mutational vectors; for introducing predetermined changes into cell genomes.

Vion Pharma WO 01/14579

Salmonella-delivered therapeutics

New Haven, Conn.

Delivery therapeutics with Salmonella containing phage whose genome has been modified with the therapeutic protein gene.

Virginia Commonwealth Univ. WO 01/13914

Complexed oligos

Richmond, Va.

Oligonucleotides complexed to platinum compounds; for charge reduction and increased therapeutic efficacy.

Virginia Mason Res. Ctr. WO 01/13934

Diabetes-related autoantigen

Seattle

Peptides from diabetes-related autoantigen GAD65, analogs; for treating diabetes and pancreas transplant rejection.

Yissum Res. & Devlop. WO 01/15531

Inhibiting cell proliferation

Jerusalem

Administration of a T2 family ribonuclease; for inhibiting cell proliferation and differentiation.

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