March 7 & 14 (EP), March 1 & 8 (WO)
Absorber WO 01/13947
Reducing xenotransplant immunogenicity
Reduction of xenotransplant tissue immunogenicity by removing macrophages and microglial cells and antigens.
Academic Med. Ctr. EP 1 083 230
Inducible viral replicons
Inducible viral replicons for use in live-attenuated HIV vaccines.
Active Biotech WO 01/14884
Melanoma-associated antigen expressed on cell surfaces, antibodies; for diagnostics and therapeutics.
ActivePass Pharma WO 01/14414 & 14547
ABC transporter, encoding gene sequences, fusions, antigenic peptides, antibodies; for developing therapeutics.
Adv. Res. & Technol. Inst. WO 01/14418
Cell cycle regulatory protein
Cell cycle regulatory protein p193, encoding gene sequences; for developing apoptosis modulators.
Allergan Sales WO 01/14570
Activatable recombinant neurotoxins, encoded proteins, production methods; for therapeutics.
Ambergen WO 01/14578
Nascent protein detection
Boron-containing dyes for marking nascent proteins; for detection in cell-free protein synthesis systems.
Amersham Pharmacia Biotech WO 01/14568
Mutant Taq DNA polymerases
Mutant thermostable Taq DNA polymerases having improved salt tolerance, encoding gene sequences; for PCR-based methods.
Asahi EP 1 083 226
Hematopoietic cell separation
Device and methods for separating cluster differentiation-positive undifferentiated human hematopoietic cells.
AstraZeneca WO 01/14533
Yeast phosphomevalonate kinase gene, encoded protein, production methods; for antifungal screens.
Atlantic Biopharma WO 01/15709
Administration of a-feta protein or an apoptosis-inhibiting fragment; for modulating apoptosis
Babraham Inst. WO 01/13715
Animals having a manipulated vesicular monoamine transporter gene; for studying schizophrenia and other neural diseases.
Biocrystal WO 01/13945
Multiple sclerosis therapy
Affinity ligands that bind to B-cell determinants and reduce B-cell numbers; for multiple sclerosis therapy.
Biocrystal WO 01/14846 & 14881
Multiple sclerosis immunoresponse
Measurement and comparison of B-cell subpopulations; for detecting a multiple sclerosis immunoresponse.
Biofrontera Pharma EP 1 081 225 & WO 01/16176
Transgenics having an inserted parkin2 gene with mutations characteristic of Parkinson's; for disease modeling.
BioMerieux WO 01/14586
Biochip measurement analysis
Marcy l'Etoile, France
Analyzing measurements obtained from a biochip by quantifying hybridization rates of various probes.
Brussells, Univ. of EP 1 083 227
Inducible gene therapy vector
Antibiotic modulatable vectors containing therapeutic genes; for gene therapy and immunization.
Cancer Translational Res. Ctr. WO 01/14546
Cancer transcription modulator
Replication protein A binding transcriptional factor, encoding gene; for developing cancer therapeutics.
Case Western Res. Univ. WO 01/14403
Potassium channel modulation
MinK2 protein, encoding gene sequences; for potassium channel modulator screens.
Chiron WO 01/14415
EGFH2 genes, encoded proteins, variants; for developing therapeutics.
Chugai EP 1 081 224
Membrane-bound protein genes
Methods for selectively isolating genes encoding membrane-bound proteins.
Chugai WO 01/13940
Myeloma cell antigen expression potentiators
Potentiators for the expression of HM1.24 antigen in myeloma cells that are derived form various interferons.
Chugai WO 01/14551
Cartilage differentiating factors
Transcription factor from the family of factors induced by differentiating cartilage cells; for making therapeutics.
Clarity Biosciences WO 01/14592
Intron SNPs for identification
Identifying organisms by detecting distinctive intronic nucleic acid sequence polymorphisms.
CuraGen WO 01/14564
T cell-expressed genes
New Haven, Conn.
Gene sequences expressed in activated T cells, encoded proteins, variants, fragments; for developing therapeutics.
Dana-Farber Cancer Inst. WO 01/14556 & 14557
B7-4 protein and its receptor PD-1, encoding genes; for developing immune cell activation modulators.
DeCode Genetics WO 01/14555
Human narcolepsy-associated gene, encoded hypocretin receptor 1; for developing diagnostics and therapeutics.
DNAChip WO 01/14425
Seoul, S. Korea
Protein chips on which a high density of probe arrays can be fixed; for diagnostics.
Erasmus Univ. EP 1 081 227
Tranfecting CD34+ cells
Gene delivery methods and vehicles for transfecting CD34+ cells; for gene therapy.
European Lab Molec. Biol. WO 01/14585
Immobilizing nucleic acids
Covalent immobilization of nucleic acids on a solid phase; for marking and purification.
Fibrogen WO 01/15729
Connective tissue growth factor receptor
S. San Francisco
Connective tissue growth factor receptor, encoding gene sequences, modulators; for diagnostics and therapeutics.
Fox, J.S. WO 01/14591
High-sensitivity detection and manipulation of biomolecules using magnetic particles.
Genaissance Pharma WO 01/14588
IgE receptor gene SNPs
New Haven, Conn.
Identifying polymorphisms in the immunoglobulin E receptor _ chain gene; for finding drug target isogenes.
Genencor Intl. WO 01/15521
Donor-specific immunity transgenics
Palo Alto, Calif.
Transgenics capable of facilitating production of donor-specific functional immunity.
Genentech WO 01/15730
ErbB2 antibody therapy
S. San Francisco
Administration of anti-ErbB2 antibodies for disorders characterized by ErbB2 overexpression; for cancer therapy.
Genesis Res. & Develop. WO 01/14553
Mammary gland genes
Mammary gland gene sequences, encoded proteins; for developing diagnostics and therapeutics.
Genome Therapeutics WO 01/14542
Apoptosis inducer assay
Death-domain transmembrane proteins having heterologous membrane spanning domains; for finding apoptosis inducers.
Genset WO 01/14550
Prostate cancer-related gene
Prostate cancer-related gene 3, biallelic markers, antibodies; for diagnostics and therapeutics.
HSP Res. Inst. EP 1 081 231
Recovering soluble protein
Methods for preventing aggregation and recovering soluble protein in recombinant production systems.
Human Genome Sciences WO 01/14545
PGRP-L polypeptides, encoding gene sequences, antibodies, production methods; for diagnostics and therapeutics.
Immunex WO 01/14529
Enhanced protein production
Modulating the IGF-1 signaling pathway in cultured cells to enhance improved recombinant protein production.
Immunobiology WO 01/13943
Intracellular pathogen vaccines
Isolating heat shock proteins induced by heat or TNF treatment in cells infected by intracellular pathogens.
Immunobiology WO 01/13944
Extracellular pathogen vaccines
Isolating heat shock proteins induced by heat or TNF treatment in cells infected by extracellular pathogens.
Imperial Cancer Res. Technol. WO 01/14413
Polypeptides that can interact with Smad; for assays to screen potential therapeutics.
Inoue, K., et al. WO 01/13716
Vitamin E deficiency model
Knockout animals having a modified a-tocopherol transport protein gene; for developing oxidative stress therapeutics.
Introgene EP 1 083 228
Adenoviral gene therapy vectors
Adenoviral vectors lacking E1A and E1B gene sequences and having reduced E2B and E4 gene expression; for gene therapy.
Introgene EP 1 083 231
Smooth muscle cell promoter
Smooth muscle cell-specific gene promoters; for use in adenoviral gene therapy vectors.
Isis Pharma WO 01/14402
Antisense to the focal adhesion kinase encoding gene; for disease-related expression modulation.
Isis Pharma WO 01/15739
Rho family gene antisense
Antisense to Rho family genes that express low-molecular-weight GTPases; for hyperproliferative disorders.
Janssen Pharma WO 01/14549
Conditional cell death
Conditional cell death system based on apoptosis gene promoter controlled heterologous gene expression.
Johns Hopkins Univ. WO 01/14539
Nucleic acid fusion libraries
Nucleic acid fusion libraries in which members have nucleic acid modification and enzyme attachment sequence domains.
Jung, G., et al. Ep 1 083 232
Methods for transferring mRNA into cells by using polycationic peptide compounds.
Kirin WO 01/14522
Yeast production system
Yeast strains that can produce glycoproteins with mammalian type sugar chains; for heterologous protein production.
Kurokawa, K. WO 01/14552
Mesangial cell protein
Mesangial cell protein MEG-1, encoding gene sequences; for developing diagnostics and therapeutics.
Kyowa Medex EP 1 083 428
Detecting HCV core antigens
Detecting human cytomegalovirus core antigens by using specific antibodies.
Leadd EP 1 081 226, 1 083 224, & WO 01/16165
Apoptin-associating protein; for developing therapeutics for cells in which p53 is at least partially nonfunctional.
Lexicon Genetics WO 01/14422
Mammary gland cDNA
The Woodlands, Texas
Gene sequence derived from a mammary gland cDNA library; for developing diagnostics and therapeutics.
Lin, S.L. WO 01/13959
Gene function knockout methods
Methods for gene function knockout by covalently binding antisense probes to gene transcripts.
Luminex WO 01/14589
Liquid nucleic acid arrays
Quantitating nucleic acids using oligo probes coupled to fluorescently addressable multicolored microparticles.
Mass. Gen. Hosp. WO 01/13948
Sepsis therapeutics targets
Outer membrane protein A, peptidolycan-associated lipoprotein, and murein lipoprotein as sepsis targets.
Maxygen WO 01/15736
Interferon-_ like molecules
Non-polypeptide moiety linked to a mutant interferon-_; for immunotherapy.
Medarex WO 01/14424
Human CTLA-4 antibodies
Human CTLA-4 antibodies; for treating various diseases including infections.
MedImmune WO 01/14421
Homologs of Streptococcus pneumoniae Sp36 protein, encoding genes, fragments; for developing vaccines.
Merck WO 01/14416
Synthetic papillomavirus genes
Synthetic DNA molecules encoding human papillomavirus proteins; for developing vaccines.
Merck WO 01/14548
G-protein coupled receptor
G-protein coupled receptor, encoding gene sequences, production methods; for developing therapeutics.
Michigan, Univ. of WO 01/15731
C5A antibodies for sepsis
Ann Arbor, Mich.
Methods and compositions for treating sepsis by using C5A antibodies and C-terminal truncations.
MorphoSys WO 01/14558
Human antibodies to histocompatibility antigen HLA-Cw6, encoding gene sequences, fragments; for therapeutics.
Ortho-McNeil Pharma WO 01/15520
Transgenics having a modified PA28 gene and thus producing inactivated PA28, derived cells and cell lines.
Pharmacia & Upjohn WO 01/14544
Transcription factor assay
Nucleotide sequence having a binding site for the human fork head transcription factor Afx; for modulator screens.
Pharmacia & Upjohn WO 01/14554
G protein-coupled receptor
G protein-coupled receptor expressed in brain, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Pharmacia & Upjohn WO 01/14584
Identifying specific inhibitors of human papillomavirus E7 binding to the CDK2 complex; for designing antivirals.
Pittsburgh, Univ. of WO 01/13960
Cartilage gene therapy
Transfection of subchondral cells in a joint in vivo; for gene therapy.
Pittsburgh, Univ. of WO 01/15511
Nuclear transport facilitating peptides
Identification of internalizing peptides that facilitate the cytoplasmic uptake and nuclear transport of proteins.
Promega WO 01/14590
DNA isolation and sequencing
Simultaneous isolation and quantitation of DNA by amplification, short tandem repeat analysis, and sequencing.
Ramot Univ. WO 01/15655
Tel Aviv, Israel
Antibodies to peptides involved in neurodegenerative diseases; for diagnostics and therapeutics.
Sembiosys Genetics WO 01/14571
Chymosin from plants
Commercial production of chymosin in plants using recombinant expression methods.
SmithKline Beecham WO 01/14409
Bacterial deoxyxylulose-5-phosphate synthase, encoding gene, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 01/14410
PAFR-line 7-transmembrane receptor, encoding gene, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 01/14423
Calcium channel proteins
Calcium channel proteins, encoding genes, production methods; for developing diagnostics and therapeutics.
SmithKline Beecham WO 01/14523, 16173 & 16351
Bacterial tktA, fabF, and dnaE polypeptides, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 01/14577
Galanin-like 7-transmembrane receptor, encoding gene, recombinant production methods; for therapeutics.
Subsidiary No. 3 WO 01/15741, 16322 & 16323
HIV suppressor elements
Genetic elements and corresponding cellular genes that suppress HIV activities, identification of such sequences.
Sumitomo Pharma WO 01/14582
ER protein gene transfection
Transfecting genes encoding endoplasmic reticulum membrane proteins that participate in protein transport.
Takeda Chemical EP 1 081 222
19P2 ligand antibodies
Anti-19P2 ligand monoclonal antibodies; for neutralizing the arachidonic acid releasing activity of the 19P2 ligand.
Takeda Chemical EP 1 083 223
Immortalized liver cell line
Immortalized human liver cell line derived from fetal tissue; for studying metabolism.
Texas, Univ. of WO 01/14581
Treating cardiac hypertrophy
Modulation of HDAC4/5 regulation of cardiac gene expression; for treating cardiac hypertrophy.
Texas Biotech WO 01/14404
Junctional adhesion protein gene
Gene sequences encoding a human junctional adhesion protein, encoded protein; for developing therapeutics.
Torino, Univ. of WO 01/14420
Plexin neuropilin multimeric receptor complexes for semaphorins, encoding genes; for treating neural diseases.
University Health Network WO 01/15728
Activating cytotoxic T cells
Activating cytotoxic T cells using CD40 antibodies and an antigen; for destroying antigen-presenting cells.
Urogene WO 01/13714
Prostate cancer cells
Prostate cancer cell line; for inducing cancer in an animal model and generating diagnostics antibodies.
Valigen WO 01/15740
Single-stranded mutational vectors
Single-stranded mutational vectors; for introducing predetermined changes into cell genomes.
Vion Pharma WO 01/14579
New Haven, Conn.
Delivery therapeutics with Salmonella containing phage whose genome has been modified with the therapeutic protein gene.
Virginia Commonwealth Univ. WO 01/13914
Oligonucleotides complexed to platinum compounds; for charge reduction and increased therapeutic efficacy.
Virginia Mason Res. Ctr. WO 01/13934
Peptides from diabetes-related autoantigen GAD65, analogs; for treating diabetes and pancreas transplant rejection.
Yissum Res. & Devlop. WO 01/15531
Inhibiting cell proliferation
Administration of a T2 family ribonuclease; for inhibiting cell proliferation and differentiation.