January 3 (EP); December 28 (WO)

Adv. Res. & Technol. Inst. WO 00/78119

Proliferating cardiomyocytes


Use of increased cyclin D2 activity to activate the cell cycle of cardiomyocytes; for enhanced proliferation.

Aisin Seiki EP 1 065 279

DNA ligation

Aichi, Japan

Ligation of double-stranded DNAs in the presence of RecA; introduction of the DNA complex into cells.

Allergene WO 00/78346

Anti-allergic agents

Ramat Gan, Israel

Complexes with cell penetration and mast cell degranulation inhibitor moieties; for making anti-allergic agents.

Amgen WO 00/78964

Glycoprotein hormone

Thousand Oaks, Calif.

Glycoprotein hormone family member, encoding gene sequences, production methods; for diagnostics and therapeutics.

Amylin Pharma WO 00/78950

Obesity-related genes

San Diego

Differentially expressed genes in obese mice, encoded proteins; for developing obesity therapeutics.

Applied Molec. Evolution WO 00/78815

Inhibiting av_2 function

San Diego

Enhanced LM609 grafted antibodies to av_2, encoding gene sequences; for inhibiting av_2 function.

Ariad Gene Therapeutics WO 00/78951

Chimeric transcription factors

Cambridge, Mass.

Chimeric OCA-B transcription factors; for heterologous expression in transgenics.

AstraZeneca WO 00/79003

HMG-CoA reductase polymorphisms


Human HMG-CoA reductase gene polymorphisms, encoded proteins; for cardiovascular disease diagnosis.

Aventis Pharma WO 00/78811

Antithrombin variants


Human antithrombin variants having high protease activity even in the absence of heparin.

Aventis Pharma WO 00/78970

Cholesterol therapeutics

Antony, France

Human ABC1 transporter gene, encoded protein; for cholesterol metabolism diagnostics and therapeutics.

Aventis Pharma WO 00/78977

Large insert cloning

Bridgewater, N.J.

Facilitating the cloning of large inserts into low copy number plasmids; for enhanced gene expression.

Aventis Pharma WO 00/78986

Regulated transgene expression

Antony, France

Regulated system of transgene expression using nuclear PPAR receptors; for disease therapy

BASF WO 00/78933


Ludwigshafen, Germany

Calpains, encoding gene sequences; for diagnostics and therapeutics.

Baylor Coll. Med. WO 00/79264

Gene expression regulation


Detection of mutations affecting gene expression by using a reporter gene linked to regulatory sequences.

Bio Merieux WO 00/78990

HIV resistance

Marcy l'Etoile, France

Assays for mutations in HIV 2 proteases; for diagnosing resistance to therapeutics.

Biotherapies WO 00/78955

Epithelial cell growth inhibitors

Ann Arbor, Mich.

Epithelial cell growth inhibitors differentially expressed in cancers, encoding gene sequences; for therapeutics.

Boehringer Ingelheim EP 1 065 215

AMPA glutamate receptor modulators

Ingelheim, Germany

Recombinant homomeric and heteromeric AMPA glutamate receptor; for identifying modulators.

Caprion Pharma WO 00/78344

Prion therapeutics

Montreal, Que.

Prion protein peptides, antigenic fragments, antibodies; for diagnostics and therapeutics.

Catholic Univ. WO 00/78814

CD2 antibodies

Louvain, Belgium

Monoclonal antibodies to human/baboon CD2; for modulating immune responses mediated by T cell proliferation.

Cooper, G.J.S., et al. WO 00/78805

Insulin secretion stimulator

Auckland, New Zealand

Peptide secreted by pancreatic _ cells called preptin; for stimulating insulin secretion.

Corixa WO 00/78960

Breast cancer therapeutics


Breast tumor proteins, encoding gene sequences, immunogenic fragments; for diagnostics and therapeutics.

CuraGen WO 00/78802

SECX polypeptides

New Haven, Conn.

SECX polypeptides, encoding gene sequences, fragments, muteins, antibodies; for diagnostics and therapeutics.

CV Therapeutics WO 00/78971 & 78972

Cholesterol therapeutics

Palo Alto, Calif.

ATP binding cassette transporter protein, encoding gene; for increasing cholesterol efflux and raising HDL levels.

DNAVec Res. WO 00/78987

Gene therapy vector

Ibaraki, Japan

Lentivirus-based vector for expressing two foreign genes; for gene therapy.

Du Pont WO 00/78957 & 78958

Scorpion toxins

Wilmington, Del.

Scorpion toxins that modulate sodium channel activity, encoding gene sequences, antisense; for therapeutics.

Dundee, Univ. of WO 00/78803

Cell death induction

Dundee, U.K.

eIF4E binding peptides or peptidomimetics; for inducing cell death.

Eastern Virginia Med. Sch. WO 00/78946

NO synthase antisense

Norfolk, Va.

Antisense oligos to inducible nitric oxide synthase; for lessening lung NO toxicity and enhancing flu recovery.

Emory Univ. WO 00/78813

Huntington's cellular model

Atlanta, Ga.

Stably transfected PC12 cells expressing mutant huntingtin; for use as a cellular Huntington's disease model.

Ferry, J.G., et al. WO 00/78342

Tuberculosis therapy

Pittsburgh, Penn.

Targeting carbon monoxide dehydrogenase in tuberculosis-related mycoplasm; for therapy.

Forssmann, W.-G. WO 00/78963

Serine proteinase inhibitors

Hannover, Germany

Serine proteinase inhibitors, encoding gene sequences; for diagnostics and therapeutics.

Fred Hutchinson Cancer Res. Ctr. WO 00/79006

High resolution HLA typing


Oligonucleotide arrays of HLA Class I genes; for high resolution tissue typing.

Fuji Photo Film EP 1 065 280

Standardized DNA chip

Kanagawa, Japan

DNA chip with sections that have the same and different base sequences; for internal standardization in gene assays.

Gene Logic WO 00/78788

Nephropathy-associated genes

Gaithersburg, Md.

Differential gene expression patterns in normal and diseased kidneys; for finding nephropathy-associated genes.

GeneSource WO 00/78942

Gene expression assay

Palo Alto, Calif.

Expression of a marker gene occurring in cell membranes; for non-destructive cell-based gene expression assays.

Genentech WO 00/78801

IGF agonist peptides

S. San Francisco

Insulin-like growth factor agonist peptides that prevent binding to receptors; for therapeutics.

Genentech WO 00/78961

Secreted proteins

S. San Francisco

Secreted and transmembrane proteins, encoding gene sequences, chimeras, fusions, antibodies.

Hyseq WO 00/79007

Sequence assembly

Sunnyvale, Calif.

Methods of sequence assembly in sequencing by hybridization that counts imperfectly matched DNA duplexes.

Immunex WO 00/78962

Immunoglobulin family gene


Immunoglobulin superfamily gene expressed in human leukocytes, encoded protein, fragments, antibodies.

Incyte Genomics WO 00/78952

RNA metabolism proteins

Palo Alto, Calif.

RNA metabolism proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/78953

Human transport proteins

Palo Alto, Calif.

Human transport proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/78954

Transcriptional regulator proteins

Palo Alto, Calif.

Human transcriptional regulator proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/78968

Moraxella therapeutics

Palo Alto, Calif.

Moraxella catarrhalis genome sequences, encoded proteins, fragments; fpr diagnostics and therapeutics.

Japan Tobacco EP 1 065 213

Hepatitis C polymerase inhibitors


Hepatitis C virus polymerase preparation suitable for crystal structure analysis; for finding inhibitors.

Johns Hopkins Univ. WO 00/78921

Cytoskeleton modulators


Shank proteins, encoding gene sequences; for finding modulators that affect cytoskeletal stability.

Johns Hopkins Univ. WO 00/78943

Late onset neuropathies


CAG repeat expansion in the 5' region of a protein phosphatase gene; for diagnosing neurological disease.

Johns Hopkins Univ. WO 00/79010

Inhibiting HIV transmission


Prevention of transepithelial transmission of HIV using ICAM-1 adhesion modulators applied to mucosal surfaces.

Joslin Diabetes Ctr. WO 00/78929

Making pancreatic islets


Differentiated pancreatic cells derived from dedifferentiated cells; for making pancreatic islets.

Kairos Scientific WO 00/78997

Enzyme kinetics assays

Santa Clara, Calif.

Solid phase enzyme kinetics screening in cell microcolonies; for high-throughput assays.

Kirin WO 00/78804

Immunoregulatory proteins


Antigen-nonspecific human glycosylation inhibitor, variants: for immune response regulation.

Krebs Res. Ctr. EP 1 065 271

Antibody screen

Heidelberg, Germany

Phagemid encoding a coliphage pIII-antibody fusion; for antibody library screening [in German].

Krebs Res. Ctr. WO 00/78939

Cancer gene therapy

Heidelberg, Germany

Expression vector having tissue-specific promoters and enhancers linked to a cytotoxin gene; for cancer therapy.

Kyowa Hakko Kogyo EP 1 065 281

Steroid sulfatase inhibitors


Introduction of the steroid sulfatase gene into cells; for screening enzyme inhibitors.

Lexicon Genetics WO 00/78959

Signal transduction genes

The Woodlands, Texas

Human signal transduction pathway genes, encoded proteins; for diagnostics and therapeutics.

London, Univ. of WO 00/78934 & 79267

Ubiquitin-specific protease


Chromosome 21 gene encoding a ubiquitin-specific protease; for cancer and Alzheimer's therapeutics.

Louis Pasteur, Univ. of WO 00/78948

Rat brain GABA receptor

Strasbourg, France

Rat brain GABA receptor, encoding gene sequences; for developing therapeutics.

Ludwig Inst. Cancer Res. WO 00/78806

MAGE-A1 peptides

New York

MAGE-A1 peptides presented by HLA Class II molecules, encoding genes, antibodies; for cancer therapy.

Maryland, Univ. of WO 00/78266

Interferon-tau mutants

College Park, Md.

Interferon-tau mutants having amino acid residue changes in the N-terminal region; for improved antiviral activity.

Medimmune WO 00/78800

Lyme disease vaccines

Gaithersburg, Md.

Borrelia decorin binding and outer surface proteins; for Lyme disease vaccines.

Merck WO 00/78947

Calcium binding protein

Darmstadt, Germany

Head trauma-induced cytoplasmic calcium binding protein, encoding gene, production methods; for diagnostics.

Millennium Pharma WO 00/78808

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding gene sequences, fusion peptides, antibodies; for diagnostics and therapeutics.

Molec. Genetics & Devlop. Res. Assoc. WO 00/78949

Cell proliferation modulation


Inverted CCAAT box binding protein, encoding gene sequences, antibodies; for modulating cell proliferation.

Molecular Geriatrics WO 00/78807

Alzheimer's diagnostics

Vernon Hills, Ill.

Purified Alzheimer's disease antigen that is different from tau; for diagnostics and therapeutics.

Murdoch Children's Res. Inst. WO 00/78341

Skin disorder therapy

Parkville, Australia

Modulation of growth factor interaction with its receptor on epidermal keratinocytes; for treating skin disorders.

NIH (Natl. Inst. Hlth.) WO 00/78969

Immune responses to HIV

Bethesda, Md.

HIV Tat peptides, multiple peptide conjugate system, production methods; for inducing immune responses.

New York, State Univ. of WO 00/78966

Lyme disease vaccines

Stony Brook, N.Y.

Immunogenic compositions and fragments from OspC proteins from Borrelia; for Lyme disease vaccines.

North Carolina State Univ. WO 00/78922

Recombinant protein production

Raleigh, N.C.

Acid-inducible promoters from Lactobacillus acidophilus; for linkage to therapeutic genes for their expression.

Oregon Hlth. Sci. Univ. WO 00/78930

Enhancing hematopoiesis

Portland, Ore.

Implantation of vascular tissue that enhances hematopoiesis, assays for modulators.

Otsuka Pharma EP 1 065 270

Cell growth regulator


Human p51 genes, encoded proteins; for regulating cell proliferation.

Pasteur Inst. EP 1 065 212

Cytotoxic T cell inducers

Lille, France

Lipopeptides that induce cytotoxic T cells; for use as a vaccine [in French].

Peschel, H. WO 00/78931

Neuronal transplant material

Gummersbach, Germany

Neuronal progenitor cells devoid of physiologically active parts of glial cells; for transplants.

SmithKline Beecham WO 00/78780

Antibacterial screens


Bacterial FabZ polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/78782

Staphylococcus antibacterials


Staphylococcus acetyl Coenzyme A carboxylase, encoding gene, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/78784

Antibacterial screens


Bacterial treP polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/78785

Antibacterial screens


Bacterial lacA polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/78786

Antibacterial screens


Bacterial galK polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/78809

G protein coupled receptor


G protein coupled receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/78935

Antibacterial screens


Bacterial mevalonate pathway genes, encoded enzymes, recombinant production methods; for antibacterial screens.

Source Precision Med. WO 00/78812

Serine elastase inhibitors

Boulder, Colo.

Methods and compounds for inhibiting the activity of serine elastases.

Spanish Counc. Sci. Res. WO 00/78976

Regulated gene expression

Madrid, Spain

Regulated expression of cloned genes using a cascade genetic circuit having several regulatory genes in sequence.

Stratagene WO 00/78945

Enriching polymorphisms

La Jolla, Calif.

Methods of enriching for and identifying polymorphisms by replicating a subset of nucleic acid molecules.

Texas, Univ. of EP 1 064 952

neu transformation suppression

Austin, Texas

Introduction of adenovirus early 1A gene or large T antigen into cells; for suppression of neu oncogene activity.

Utah, Univ. of WO 00/78787

Virulent Streptococci vaccines

Salt Lake City, Utah

Isolated genes from virulent Group B Streptococci; for diagnostics and immunization.

Vermont, Univ. of WO 00/78348

Autologous immunotherapy

Burlington, Vt.

Autologous adoptive immunotherapy using primed antigen-specific T or B cells; for antigen-specific responses.

Vermont, Univ. of WO 00/78941

Uncoupling protein control

Burlington, Vt.

Methods, compositions, and assays for manipulation of uncoupling protein expression in cell membranes.

Victor Chang Cardiac Res. Inst. WO 00/78347

Cancer cell growth inhibition

Darlinghurst, Australia

Preventing or reducing Erb-2/Erb-3 heterodimer formation; for inhibiting or arresting cancer cell growth.

Virologic WO 00/78996

AIDS therapy monitoring

S. San Francisco

Assays for HIV protease mutations; for monitoring AIDS antiretroviral therapy.

Virtek Vision WO 00/78993

Biochip analysis

Woburn, Mass.

Simultaneous image acquisition using multiple fluorophore probe dyes when scanning DNA samples on biochips.

Vlaams Biotech. Inst. WO 00/79000

Alzheimer's disease diagnosis

Zwijnaarde, Belgium

Measurement of presenilin-1 variants; for diagnosing early-onset Alzheimer's disease.

Wales, Univ. of Coll. Med. WO 00/78927

3-D cultured cells

Cardiff, U.K.

Spheroid preparations formed by heating fetal calf serum; for causing three-dimensional growth of cultured cells.

Wistar Inst. Anatomy & Biol. WO 00/78956



Pyrrhocoricin-derived peptides, encoding genes; for antibacterials and antifungals.

Zurich, Univ. of WO 00/78940

Diabetes insect model

Zurich, Switzerland

Drosophila chico mutants; for investigating Type 2 diabetes and developing therapeutics.

ZymoGenetics WO 00/78978

Recombinant protein production


Pichia methanolica glyceraldehyde 5-phosphate dehydrogenase 1 promoter and terminator; for foreign protein production.