January 3 (EP); December 28 (WO)
Adv. Res. & Technol. Inst. WO 00/78119
Proliferating cardiomyocytes
Indianapolis
Use of increased cyclin D2 activity to activate the cell cycle of cardiomyocytes; for enhanced proliferation.
Aisin Seiki EP 1 065 279
DNA ligation
Aichi, Japan
Ligation of double-stranded DNAs in the presence of RecA; introduction of the DNA complex into cells.
Allergene WO 00/78346
Anti-allergic agents
Ramat Gan, Israel
Complexes with cell penetration and mast cell degranulation inhibitor moieties; for making anti-allergic agents.
Amgen WO 00/78964
Glycoprotein hormone
Thousand Oaks, Calif.
Glycoprotein hormone family member, encoding gene sequences, production methods; for diagnostics and therapeutics.
Amylin Pharma WO 00/78950
Obesity-related genes
San Diego
Differentially expressed genes in obese mice, encoded proteins; for developing obesity therapeutics.
Applied Molec. Evolution WO 00/78815
Inhibiting av_2 function
San Diego
Enhanced LM609 grafted antibodies to av_2, encoding gene sequences; for inhibiting av_2 function.
Ariad Gene Therapeutics WO 00/78951
Chimeric transcription factors
Cambridge, Mass.
Chimeric OCA-B transcription factors; for heterologous expression in transgenics.
AstraZeneca WO 00/79003
HMG-CoA reductase polymorphisms
London
Human HMG-CoA reductase gene polymorphisms, encoded proteins; for cardiovascular disease diagnosis.
Aventis Pharma WO 00/78811
Antithrombin variants
Tokyo
Human antithrombin variants having high protease activity even in the absence of heparin.
Aventis Pharma WO 00/78970
Cholesterol therapeutics
Antony, France
Human ABC1 transporter gene, encoded protein; for cholesterol metabolism diagnostics and therapeutics.
Aventis Pharma WO 00/78977
Large insert cloning
Bridgewater, N.J.
Facilitating the cloning of large inserts into low copy number plasmids; for enhanced gene expression.
Aventis Pharma WO 00/78986
Regulated transgene expression
Antony, France
Regulated system of transgene expression using nuclear PPAR receptors; for disease therapy
BASF WO 00/78933
Calpains
Ludwigshafen, Germany
Calpains, encoding gene sequences; for diagnostics and therapeutics.
Baylor Coll. Med. WO 00/79264
Gene expression regulation
Houston
Detection of mutations affecting gene expression by using a reporter gene linked to regulatory sequences.
Bio Merieux WO 00/78990
HIV resistance
Marcy l'Etoile, France
Assays for mutations in HIV 2 proteases; for diagnosing resistance to therapeutics.
Biotherapies WO 00/78955
Epithelial cell growth inhibitors
Ann Arbor, Mich.
Epithelial cell growth inhibitors differentially expressed in cancers, encoding gene sequences; for therapeutics.
Boehringer Ingelheim EP 1 065 215
AMPA glutamate receptor modulators
Ingelheim, Germany
Recombinant homomeric and heteromeric AMPA glutamate receptor; for identifying modulators.
Caprion Pharma WO 00/78344
Prion therapeutics
Montreal, Que.
Prion protein peptides, antigenic fragments, antibodies; for diagnostics and therapeutics.
Catholic Univ. WO 00/78814
CD2 antibodies
Louvain, Belgium
Monoclonal antibodies to human/baboon CD2; for modulating immune responses mediated by T cell proliferation.
Cooper, G.J.S., et al. WO 00/78805
Insulin secretion stimulator
Auckland, New Zealand
Peptide secreted by pancreatic _ cells called preptin; for stimulating insulin secretion.
Corixa WO 00/78960
Breast cancer therapeutics
Seattle
Breast tumor proteins, encoding gene sequences, immunogenic fragments; for diagnostics and therapeutics.
CuraGen WO 00/78802
SECX polypeptides
New Haven, Conn.
SECX polypeptides, encoding gene sequences, fragments, muteins, antibodies; for diagnostics and therapeutics.
CV Therapeutics WO 00/78971 & 78972
Cholesterol therapeutics
Palo Alto, Calif.
ATP binding cassette transporter protein, encoding gene; for increasing cholesterol efflux and raising HDL levels.
DNAVec Res. WO 00/78987
Gene therapy vector
Ibaraki, Japan
Lentivirus-based vector for expressing two foreign genes; for gene therapy.
Du Pont WO 00/78957 & 78958
Scorpion toxins
Wilmington, Del.
Scorpion toxins that modulate sodium channel activity, encoding gene sequences, antisense; for therapeutics.
Dundee, Univ. of WO 00/78803
Cell death induction
Dundee, U.K.
eIF4E binding peptides or peptidomimetics; for inducing cell death.
Eastern Virginia Med. Sch. WO 00/78946
NO synthase antisense
Norfolk, Va.
Antisense oligos to inducible nitric oxide synthase; for lessening lung NO toxicity and enhancing flu recovery.
Emory Univ. WO 00/78813
Huntington's cellular model
Atlanta, Ga.
Stably transfected PC12 cells expressing mutant huntingtin; for use as a cellular Huntington's disease model.
Ferry, J.G., et al. WO 00/78342
Tuberculosis therapy
Pittsburgh, Penn.
Targeting carbon monoxide dehydrogenase in tuberculosis-related mycoplasm; for therapy.
Forssmann, W.-G. WO 00/78963
Serine proteinase inhibitors
Hannover, Germany
Serine proteinase inhibitors, encoding gene sequences; for diagnostics and therapeutics.
Fred Hutchinson Cancer Res. Ctr. WO 00/79006
High resolution HLA typing
Seattle
Oligonucleotide arrays of HLA Class I genes; for high resolution tissue typing.
Fuji Photo Film EP 1 065 280
Standardized DNA chip
Kanagawa, Japan
DNA chip with sections that have the same and different base sequences; for internal standardization in gene assays.
Gene Logic WO 00/78788
Nephropathy-associated genes
Gaithersburg, Md.
Differential gene expression patterns in normal and diseased kidneys; for finding nephropathy-associated genes.
GeneSource WO 00/78942
Gene expression assay
Palo Alto, Calif.
Expression of a marker gene occurring in cell membranes; for non-destructive cell-based gene expression assays.
Genentech WO 00/78801
IGF agonist peptides
S. San Francisco
Insulin-like growth factor agonist peptides that prevent binding to receptors; for therapeutics.
Genentech WO 00/78961
Secreted proteins
S. San Francisco
Secreted and transmembrane proteins, encoding gene sequences, chimeras, fusions, antibodies.
Hyseq WO 00/79007
Sequence assembly
Sunnyvale, Calif.
Methods of sequence assembly in sequencing by hybridization that counts imperfectly matched DNA duplexes.
Immunex WO 00/78962
Immunoglobulin family gene
Seattle
Immunoglobulin superfamily gene expressed in human leukocytes, encoded protein, fragments, antibodies.
Incyte Genomics WO 00/78952
RNA metabolism proteins
Palo Alto, Calif.
RNA metabolism proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/78953
Human transport proteins
Palo Alto, Calif.
Human transport proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/78954
Transcriptional regulator proteins
Palo Alto, Calif.
Human transcriptional regulator proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/78968
Moraxella therapeutics
Palo Alto, Calif.
Moraxella catarrhalis genome sequences, encoded proteins, fragments; fpr diagnostics and therapeutics.
Japan Tobacco EP 1 065 213
Hepatitis C polymerase inhibitors
Tokyo
Hepatitis C virus polymerase preparation suitable for crystal structure analysis; for finding inhibitors.
Johns Hopkins Univ. WO 00/78921
Cytoskeleton modulators
Baltimore
Shank proteins, encoding gene sequences; for finding modulators that affect cytoskeletal stability.
Johns Hopkins Univ. WO 00/78943
Late onset neuropathies
Baltimore
CAG repeat expansion in the 5' region of a protein phosphatase gene; for diagnosing neurological disease.
Johns Hopkins Univ. WO 00/79010
Inhibiting HIV transmission
Baltimore
Prevention of transepithelial transmission of HIV using ICAM-1 adhesion modulators applied to mucosal surfaces.
Joslin Diabetes Ctr. WO 00/78929
Making pancreatic islets
Boston
Differentiated pancreatic cells derived from dedifferentiated cells; for making pancreatic islets.
Kairos Scientific WO 00/78997
Enzyme kinetics assays
Santa Clara, Calif.
Solid phase enzyme kinetics screening in cell microcolonies; for high-throughput assays.
Kirin WO 00/78804
Immunoregulatory proteins
Tokyo
Antigen-nonspecific human glycosylation inhibitor, variants: for immune response regulation.
Krebs Res. Ctr. EP 1 065 271
Antibody screen
Heidelberg, Germany
Phagemid encoding a coliphage pIII-antibody fusion; for antibody library screening [in German].
Krebs Res. Ctr. WO 00/78939
Cancer gene therapy
Heidelberg, Germany
Expression vector having tissue-specific promoters and enhancers linked to a cytotoxin gene; for cancer therapy.
Kyowa Hakko Kogyo EP 1 065 281
Steroid sulfatase inhibitors
Tokyo
Introduction of the steroid sulfatase gene into cells; for screening enzyme inhibitors.
Lexicon Genetics WO 00/78959
Signal transduction genes
The Woodlands, Texas
Human signal transduction pathway genes, encoded proteins; for diagnostics and therapeutics.
London, Univ. of WO 00/78934 & 79267
Ubiquitin-specific protease
London
Chromosome 21 gene encoding a ubiquitin-specific protease; for cancer and Alzheimer's therapeutics.
Louis Pasteur, Univ. of WO 00/78948
Rat brain GABA receptor
Strasbourg, France
Rat brain GABA receptor, encoding gene sequences; for developing therapeutics.
Ludwig Inst. Cancer Res. WO 00/78806
MAGE-A1 peptides
New York
MAGE-A1 peptides presented by HLA Class II molecules, encoding genes, antibodies; for cancer therapy.
Maryland, Univ. of WO 00/78266
Interferon-tau mutants
College Park, Md.
Interferon-tau mutants having amino acid residue changes in the N-terminal region; for improved antiviral activity.
Medimmune WO 00/78800
Lyme disease vaccines
Gaithersburg, Md.
Borrelia decorin binding and outer surface proteins; for Lyme disease vaccines.
Merck WO 00/78947
Calcium binding protein
Darmstadt, Germany
Head trauma-induced cytoplasmic calcium binding protein, encoding gene, production methods; for diagnostics.
Millennium Pharma WO 00/78808
Secreted proteins
Cambridge, Mass.
Secreted proteins, encoding gene sequences, fusion peptides, antibodies; for diagnostics and therapeutics.
Molec. Genetics & Devlop. Res. Assoc. WO 00/78949
Cell proliferation modulation
Paris
Inverted CCAAT box binding protein, encoding gene sequences, antibodies; for modulating cell proliferation.
Molecular Geriatrics WO 00/78807
Alzheimer's diagnostics
Vernon Hills, Ill.
Purified Alzheimer's disease antigen that is different from tau; for diagnostics and therapeutics.
Murdoch Children's Res. Inst. WO 00/78341
Skin disorder therapy
Parkville, Australia
Modulation of growth factor interaction with its receptor on epidermal keratinocytes; for treating skin disorders.
NIH (Natl. Inst. Hlth.) WO 00/78969
Immune responses to HIV
Bethesda, Md.
HIV Tat peptides, multiple peptide conjugate system, production methods; for inducing immune responses.
New York, State Univ. of WO 00/78966
Lyme disease vaccines
Stony Brook, N.Y.
Immunogenic compositions and fragments from OspC proteins from Borrelia; for Lyme disease vaccines.
North Carolina State Univ. WO 00/78922
Recombinant protein production
Raleigh, N.C.
Acid-inducible promoters from Lactobacillus acidophilus; for linkage to therapeutic genes for their expression.
Oregon Hlth. Sci. Univ. WO 00/78930
Enhancing hematopoiesis
Portland, Ore.
Implantation of vascular tissue that enhances hematopoiesis, assays for modulators.
Otsuka Pharma EP 1 065 270
Cell growth regulator
Tokyo
Human p51 genes, encoded proteins; for regulating cell proliferation.
Pasteur Inst. EP 1 065 212
Cytotoxic T cell inducers
Lille, France
Lipopeptides that induce cytotoxic T cells; for use as a vaccine [in French].
Peschel, H. WO 00/78931
Neuronal transplant material
Gummersbach, Germany
Neuronal progenitor cells devoid of physiologically active parts of glial cells; for transplants.
SmithKline Beecham WO 00/78780
Antibacterial screens
Philadelphia
Bacterial FabZ polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/78782
Staphylococcus antibacterials
Philadelphia
Staphylococcus acetyl Coenzyme A carboxylase, encoding gene, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/78784
Antibacterial screens
Philadelphia
Bacterial treP polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/78785
Antibacterial screens
Philadelphia
Bacterial lacA polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/78786
Antibacterial screens
Philadelphia
Bacterial galK polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/78809
G protein coupled receptor
Philadelphia
G protein coupled receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/78935
Antibacterial screens
Philadelphia
Bacterial mevalonate pathway genes, encoded enzymes, recombinant production methods; for antibacterial screens.
Source Precision Med. WO 00/78812
Serine elastase inhibitors
Boulder, Colo.
Methods and compounds for inhibiting the activity of serine elastases.
Spanish Counc. Sci. Res. WO 00/78976
Regulated gene expression
Madrid, Spain
Regulated expression of cloned genes using a cascade genetic circuit having several regulatory genes in sequence.
Stratagene WO 00/78945
Enriching polymorphisms
La Jolla, Calif.
Methods of enriching for and identifying polymorphisms by replicating a subset of nucleic acid molecules.
Texas, Univ. of EP 1 064 952
neu transformation suppression
Austin, Texas
Introduction of adenovirus early 1A gene or large T antigen into cells; for suppression of neu oncogene activity.
Utah, Univ. of WO 00/78787
Virulent Streptococci vaccines
Salt Lake City, Utah
Isolated genes from virulent Group B Streptococci; for diagnostics and immunization.
Vermont, Univ. of WO 00/78348
Autologous immunotherapy
Burlington, Vt.
Autologous adoptive immunotherapy using primed antigen-specific T or B cells; for antigen-specific responses.
Vermont, Univ. of WO 00/78941
Uncoupling protein control
Burlington, Vt.
Methods, compositions, and assays for manipulation of uncoupling protein expression in cell membranes.
Victor Chang Cardiac Res. Inst. WO 00/78347
Cancer cell growth inhibition
Darlinghurst, Australia
Preventing or reducing Erb-2/Erb-3 heterodimer formation; for inhibiting or arresting cancer cell growth.
Virologic WO 00/78996
AIDS therapy monitoring
S. San Francisco
Assays for HIV protease mutations; for monitoring AIDS antiretroviral therapy.
Virtek Vision WO 00/78993
Biochip analysis
Woburn, Mass.
Simultaneous image acquisition using multiple fluorophore probe dyes when scanning DNA samples on biochips.
Vlaams Biotech. Inst. WO 00/79000
Alzheimer's disease diagnosis
Zwijnaarde, Belgium
Measurement of presenilin-1 variants; for diagnosing early-onset Alzheimer's disease.
Wales, Univ. of Coll. Med. WO 00/78927
3-D cultured cells
Cardiff, U.K.
Spheroid preparations formed by heating fetal calf serum; for causing three-dimensional growth of cultured cells.
Wistar Inst. Anatomy & Biol. WO 00/78956
Antibacterials
Philadelphia
Pyrrhocoricin-derived peptides, encoding genes; for antibacterials and antifungals.
Zurich, Univ. of WO 00/78940
Diabetes insect model
Zurich, Switzerland
Drosophila chico mutants; for investigating Type 2 diabetes and developing therapeutics.
ZymoGenetics WO 00/78978
Recombinant protein production
Seattle
Pichia methanolica glyceraldehyde 5-phosphate dehydrogenase 1 promoter and terminator; for foreign protein production.