August 30 (EP), August 24 (WO)
ACGT WO 00/49141
Therapeutic protein delivery
Transfecting erythroid stem cells in vitro and expression of the transfected therapeutic gene in reticulocytes in vivo.
Ajinomoto WO 00/49143
Gene expression analysis
Analysis of gene expression frequency using tagged cDNAs that cause formation of concatamers.
AlphaGene WO 00/49134
Secreted proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.
Altmann, F. WO 00/49153
Fucosyl transferase gene
Fucosyl transferase gene, variants, encoded protein; for making transgenics.
Arcaris WO 00/49417
Salt Lake City, Utah
Methods for detecting protein-ligand interactions; for characterization of these reactions.
AstraZeneca WO 00/49044
Expression of Helicobacter polypeptides in Pichia pastoris yeast; for making ulcer vaccines and finding modulators.
Athersys WO 00/49162
Increasing endogenous gene expression
Non-homologous integration of regulatory sequences for endogenous genes; for increasing expression.
Barcelona, Univ. of WO 00/49051
Adenosine receptor antibodies
Therapeutic antibodies to antigenic peptides from the third extracellular loop of the human adenosine A2B receptor.
Baxter WO 00/49047
Von Willebrand factor production
Production of von Willebrand factor from the pro-protein using thrombin digestion; for generating therapeutics.
Beth Israel Deaconess Hosp. WO 00/48621
Cell growth modulator screen
WW domain-containing polypeptides; for screening modulators of cell growth.
Bio-View WO 00/49391
Nes Zona, Israel
Optical scanning systems for morphologically identifying rare cells in cell populations; for genotyping.
Boehringer Ingelheim WO 00/48627
Affecting chromatid separation
Modulating separin-like cysteine endopeptidase proteases; for modulating sister chromatid separation.
BRAHMS Diagnostica WO 00/49050
TSH receptor blocking antibodies
Thyroid stimulating hormone (TSH) receptor monoclonal blocking antibodies; for treating hyperthyroidism.
British Columbia, Univ. of WO 00/49163
Protein production in bacteria
Caulobacter species with a secretion sequence linked to heterologous genes; for recombinant protein production.
Burnham Inst. WO 00/48464
La Jolla, Calif.
NG2/HM proteoglycan-binding peptides; for targeting therapeutics and cytotoxins to angiogenic vasculature.
Case Western Res. Univ. WO 00/49048
Bicarbonate transporter, encoding gene sequences, variants; for modulator screens.
Clontech Labs WO 00/49161
Screening cAMP modulators
Palo Alto, Calif.
Reporter constructs linked to cAMP response elements; for high-throughput assays to screen modulators.
Clontech Labs WO 00/49183
Cellular cAMP detection
Palo Alto, Calif.
Fluorescence resonance energy transfer detection of cAMP in living cells using GFP variants.
Commonwealth Serum Labs WO 00/48630
Cytotoxic T cell induction
Immunogenic complexes of charged antigens and organic carriers; for inducing cytotoxic T cell responses.
Compugen WO 00/49158
PSA splice variants
Tel Aviv, Israel
Naturally occurring splice variants the of prostate-specific antigen (PSA) gene, encoded protein; for diagnostics.
Du Pont WO 00/49156
Lysophosphatidic acid acetyltransferases
Lysophosphatidic acid acetyltransferase genes, chimeras, antisense; for altering encoded protein levels in cells.
Du Pont WO 00/49177
Prokaryotic gene expression patterns
High density sampling of differentially expressed prokaryotic genes using PCR.
DZGenes WO 00/49169
Renal disease SNPs
St. Louis, Mo.
Single nucleotide polymorphisms (SNPs) associated with end stage renal disease; for diagnostics and therapeutics.
Endogen Research WO 00/49040
Host-defense peptide from lactoferrin proteolysis that has antimicrobial and endotoxin neutralizing activity.
Faustman, D.L. WO 00/48462
Transplant rejection inhibition
Inhibition of transplant rejection by treating tissues with papain to remove MHC Class I molecules.
Febit Ferrarius Biotech WO 00/49142
Producing nucleic acids
Production of synthetic double-stranded nucleic acids using a solid surface with multiple, isolated reaction sites.
Fraunhofer Res. Inst. WO 00/49173
Separating biological materials
Methods and support system for in situ separation and processing of substances from biological materials.
Frommer, W.B. WO 00/49152
Nucleobase transporter gene
Nucleic acids that code for a nucleobase transporter, fragments; for making transgenics.
Gentra Systems WO 00/49557
Automated DNA isolation
Computer-implemented methods for automated nucleic acid isolation.
Glasgow, Univ. of WO 00/49416
Membrane receptor modulators
Receptor-reporter fusion-based assays for detecting modulators of membrane receptors.
Hanisch, F.-G. WO 00/49045
Tumor marker MUC1 variants
Tumor marker MUC1 peptide variants from the variable number of tandem repeats domain; for inducing immunoresponses.
Harbron, S. WO 00/49172
Detecting the presence of nucleases in solution or on surfaces using colorimetric assays.
Harvard Univ. WO 00/48638
Diphtheria toxin-based vaccines
Diphtheria toxin polypeptides having multiple mutations that make them useful as vaccines.
Hoffmann-La Roche EP 1 031 627
Vitamin A diagnostics
Gene for _-carotene 15,15'-dioxygenase, encoded enzyme; for vitamin A synthesis and diagnostics development.
Hong Kong, Univ. of WO 00/49132
Bone growth transgenics
Transgenics having a mutated Type X collagen gene; for studying bone growth.
Imperial College Innovations WO 00/49175
Prostate cancer diagnostics
Pax 2 gene sequences, encoded protein; for prostate cancer diagnosis and therapy.
Incyte Genomics WO 00/49043
Palo Alto, Calif.
Human lipid-associated proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Iowa, Univ. of WO 00/48622
Iowa City, Iowa
Administration of microbial or mycobacterial peptides; for inhibiting inflammation.
Isis Innovation WO 00/48631
Using CD38, fragments, and analogs to inhibit CD38 binding to follicular dendritic cells and cause immunosuppression.
Isis Pharma WO 00/49032
Oligonucleotides having alkylphosphonate linkages, optically pure dimers, preparation methods; for antisense.
Kitamura, T., et al. WO 00/49148
Cytokine receptor family protein
Cytokine receptor-like protein homologous to type I cytokine receptor family, encoding gene sequences.
Kitamura, T., et al. WO 00/49149
TNF receptor family protein
Membrane secretory protein of the TNF receptor family highly expressed in brain and skin, encoding gene sequences.
Leeds, Univ. of WO 00/49167
Herpesvirus gene therapy vectors
Latency-associated regulatory gene sequence from herpesvirus saimiri, fragments, variants; for gene therapy vectors.
Ligocyte Pharma WO 00/48633
Yeast infection therapeutic
Antibodies to a hydrophobic antigen from the cell wall of Candida yeast strains; for infection treatment.
Mass. Gen. Hosp. WO 00/49035
Gene silencing using expression of antisense from a nucleic acid sequence complementary to the gene to be inhibited.
Matsushita Electric EP 1 031 630
Detecting bacteria by infecting them with recombinant phage expressing a light-emitting protein.
McMaster Univ. WO 00/49139
Caspase-activated protein kinase
Ste20-related kinase that is activated by caspase, encoding gene sequences; for identifying analogs.
Merck WO 00/49039
Protein detection in gels
Glucose dehydrogenase fusion proteins; for detection of proteins in SDS-polyacrylamide gels.
Merck WO 00/49166 & 49168
Adenoviral gene therapy vectors
Making purified adenovirus vectors using site-specific recombinases and endonucleases to reduce helper virus.
Microbiological Res. Auth. WO 00/49176
Ultrasound DNA strand separation
Separation of nucleic acids into single strands using ultrasound; for eliminating temperature cycling in PCR.
Mt. Sinai Hosp. WO 00/49145
Hematopoietic lineage genes
Genes expressed primarily in hematopoietic lineages, encoded proteins, truncations, analogs, homologs, isoforms.
NIH (Natl. Inst. Hlth.) WO 00/49151
GABAA receptor gene polymorphisms
Human GABAA receptor a-6 subunit gene polymorphisms, encoded protein with decreased sensitivity to benzodiazepines.
NIH (Natl. Inst. Hlth.) WO 00/49410
Protein content and sequence analysis on laser capture microdissected cells; for finding tumor cell differences.
New York State Office Mental Hlth. WO 00/49160
Personality disorder polymorphisms
Phenylalanine hydroxylase gene variants; for measuring pterin homeostasis and associated personality disorders.
Novartis EP 1 031 628
Use of the CUP1 promoter in recombinant yeast strains for producing desulphatohirudin.
Pasteur Inst. WO 00/49174
Determining the sequence of the SUR1 gene; for determining the susceptibility of an NIDDM patient to sulfonylureas.
Perkin-Elmer WO 00/49178
Nucleic acid sequencing
Foster City, Calif.
Nucleic acid sequencing using target-specific primers and electrophoretic separation using a sieving matrix.
Pierre Fabre Medicament WO 00/48628 & 48629
Inducing anti-cancer immunoresponse
Klebsiella pneumoniae enterobacterium membrane protein antigen; for anti-cancer cytotoxic immune responses.
Promega WO 00/49171
Luciferase detection of cells
Detection of the presence of cells using endogenous enzymes to make ATP that is detected by luciferase.
Promega WO 00/49179-49182
Nucleic acid sequence detection
Depolymerization of nucleic acid hybrids to quantitatively and qualitatively detect the presence of specific sequences.
Qiagen EP 1 031 626
Stabilizing nucleic acids
Methods for isolating and stabilizing nucleic acids by using cation binding; for making probes [in German].
RMF Dictagene WO 00/49146
C-terminal peptide of Plasmodium circumsporozite protein in which cysteine residues are oxidized; for vaccines.
Rutgers Univ. WO 00/48632
Redox clamping agents
Redox clamping agents that maintain cells at a selected redox state; for sensitizing cells to therapeutic action.
Schubert, U., et al. WO 00/49038
Synthetic peptides from the regulatory virus protein R of HIV-1, analogs, fragments, antibodies.
Sheffield, Univ. of WO 00/49137
Pluripotent stem cells
Pluripotent stem cells containing cytoplasm from embryonic stem or germ cells and a somatic cell nucleus.
Sheffield, Univ. of WO 00/49138
Pluripotent stem cells
Pluripotent stem cells containing cytoplasm from teratocarcinoma cells and a somatic cell nucleus.
SmithKline Beecham WO 00/49033
Bacterial yybQ polypeptides, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/49042
Bacterial nadE polypeptides, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/49154
P101 protein splice variants
Splice variants of P101 protein, encoding genes, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/49170
Mouse 11cby receptor
Mouse 11cby receptor, encoding gene sequences, recombinant production methods; for screening modulators.
Stanford Univ. WO 00/49034
Naked cuticle genes
Palo Alto, Calif.
Naked cuticle genes, encoded proteins; for finding homologs and cell types based on gene expression patterns.
Sugen WO 00/49144
Pyk2 binding proteins
S. San Francisco
Pyk2 binding proteins, encoding gene sequences; for identifying other protein kinase family members.
Sumitomo Electric WO 00/49041
Inducing cell immune response
Fusion of a cytotoxic T cell epitope and the ATPase domain of heat shock protein; for cellular immune responses.
Takeda Chemical WO 00/49046
G protein-coupled receptor
Human G protein-coupled receptor, encoding gene, antibodies; for identifying modulators.
Terumo WO 00/49159
Tissue regeneration biomatrix
Fusion protein having collagen binding and therapeutic moieties; for making tissue regeneration biomatrix.
Theragene Biomed. Labs WO 00/49147
Hormone responsive sequences
Hormone responsive gene sequences, hormone-hormone receptor complexes; for gene therapy and vaccine delivery.
U.S. Surgical WO 00/49136
Tissue rejection inhibition
Genetically altered mesenchymal cells having a gene encoding an immunosuppressant; for inhibiting tissue rejection.
Virginia, Univ. of WO 00/48620
Yeast infection therapy
Yeast cell wall hydrophobic peptides that mediate pathogenesis, antibodies; for infection therapeutics.
ZymoGenetics WO 00/48625
Proteins with globular and collagen-like domains, encoding genes; for inhibiting hemostasis and immune function.