August 30 (EP), August 24 (WO)

ACGT WO 00/49141

Therapeutic protein delivery

Toronto, Ont.

Transfecting erythroid stem cells in vitro and expression of the transfected therapeutic gene in reticulocytes in vivo.

Ajinomoto WO 00/49143

Gene expression analysis

Tokyo

Analysis of gene expression frequency using tagged cDNAs that cause formation of concatamers.

AlphaGene WO 00/49134

Secreted proteins

Woburn, Mass.

Secreted proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.

Altmann, F. WO 00/49153

Fucosyl transferase gene

Vienna, Austria

Fucosyl transferase gene, variants, encoded protein; for making transgenics.

Arcaris WO 00/49417

Protein-ligand interactions

Salt Lake City, Utah

Methods for detecting protein-ligand interactions; for characterization of these reactions.

AstraZeneca WO 00/49044

Ulcer vaccines

Sodertalje, Sweden

Expression of Helicobacter polypeptides in Pichia pastoris yeast; for making ulcer vaccines and finding modulators.

Athersys WO 00/49162

Increasing endogenous gene expression

Cleveland, Ohio

Non-homologous integration of regulatory sequences for endogenous genes; for increasing expression.

Barcelona, Univ. of WO 00/49051

Adenosine receptor antibodies

Barcelona, Spain

Therapeutic antibodies to antigenic peptides from the third extracellular loop of the human adenosine A2B receptor.

Baxter WO 00/49047

Von Willebrand factor production

Vienna, Austria

Production of von Willebrand factor from the pro-protein using thrombin digestion; for generating therapeutics.

Beth Israel Deaconess Hosp. WO 00/48621

Cell growth modulator screen

Boston

WW domain-containing polypeptides; for screening modulators of cell growth.

Bio-View WO 00/49391

Cell genotyping

Nes Zona, Israel

Optical scanning systems for morphologically identifying rare cells in cell populations; for genotyping.

Boehringer Ingelheim WO 00/48627

Affecting chromatid separation

Ingelheim, Germany

Modulating separin-like cysteine endopeptidase proteases; for modulating sister chromatid separation.

BRAHMS Diagnostica WO 00/49050

TSH receptor blocking antibodies

Hennindorf, Germany

Thyroid stimulating hormone (TSH) receptor monoclonal blocking antibodies; for treating hyperthyroidism.

British Columbia, Univ. of WO 00/49163

Protein production in bacteria

Vancouver, B.C.

Caulobacter species with a secretion sequence linked to heterologous genes; for recombinant protein production.

Burnham Inst. WO 00/48464

Targeting angiogenesis

La Jolla, Calif.

NG2/HM proteoglycan-binding peptides; for targeting therapeutics and cytotoxins to angiogenic vasculature.

Case Western Res. Univ. WO 00/49048

Bicarbonate transporter

Cleveland, Ohio

Bicarbonate transporter, encoding gene sequences, variants; for modulator screens.

Clontech Labs WO 00/49161

Screening cAMP modulators

Palo Alto, Calif.

Reporter constructs linked to cAMP response elements; for high-throughput assays to screen modulators.

Clontech Labs WO 00/49183

Cellular cAMP detection

Palo Alto, Calif.

Fluorescence resonance energy transfer detection of cAMP in living cells using GFP variants.

Commonwealth Serum Labs WO 00/48630

Cytotoxic T cell induction

Parkville, Australia

Immunogenic complexes of charged antigens and organic carriers; for inducing cytotoxic T cell responses.

Compugen WO 00/49158

PSA splice variants

Tel Aviv, Israel

Naturally occurring splice variants the of prostate-specific antigen (PSA) gene, encoded protein; for diagnostics.

Du Pont WO 00/49156

Lysophosphatidic acid acetyltransferases

Wilmington, Del.

Lysophosphatidic acid acetyltransferase genes, chimeras, antisense; for altering encoded protein levels in cells.

Du Pont WO 00/49177

Prokaryotic gene expression patterns

Wilmington, Del.

High density sampling of differentially expressed prokaryotic genes using PCR.

DZGenes WO 00/49169

Renal disease SNPs

St. Louis, Mo.

Single nucleotide polymorphisms (SNPs) associated with end stage renal disease; for diagnostics and therapeutics.

Endogen Research WO 00/49040

Host-defense peptide

Knivsta, Sweden

Host-defense peptide from lactoferrin proteolysis that has antimicrobial and endotoxin neutralizing activity.

Faustman, D.L. WO 00/48462

Transplant rejection inhibition

Weston, Mass.

Inhibition of transplant rejection by treating tissues with papain to remove MHC Class I molecules.

Febit Ferrarius Biotech WO 00/49142

Producing nucleic acids

Weinheim, Germany

Production of synthetic double-stranded nucleic acids using a solid surface with multiple, isolated reaction sites.

Fraunhofer Res. Inst. WO 00/49173

Separating biological materials

Munich, Germany

Methods and support system for in situ separation and processing of substances from biological materials.

Frommer, W.B. WO 00/49152

Nucleobase transporter gene

Tubingen, Germany

Nucleic acids that code for a nucleobase transporter, fragments; for making transgenics.

Gentra Systems WO 00/49557

Automated DNA isolation

Minneapolis

Computer-implemented methods for automated nucleic acid isolation.

Glasgow, Univ. of WO 00/49416

Membrane receptor modulators

Glasgow, UK

Receptor-reporter fusion-based assays for detecting modulators of membrane receptors.

Hanisch, F.-G. WO 00/49045

Tumor marker MUC1 variants

Cologne, Germany

Tumor marker MUC1 peptide variants from the variable number of tandem repeats domain; for inducing immunoresponses.

Harbron, S. WO 00/49172

Nuclease detection

Berkhamsted, UK

Detecting the presence of nucleases in solution or on surfaces using colorimetric assays.

Harvard Univ. WO 00/48638

Diphtheria toxin-based vaccines

Cambridge, Mass.

Diphtheria toxin polypeptides having multiple mutations that make them useful as vaccines.

Hoffmann-La Roche EP 1 031 627

Vitamin A diagnostics

Basel, Switzerland

Gene for _-carotene 15,15'-dioxygenase, encoded enzyme; for vitamin A synthesis and diagnostics development.

Hong Kong, Univ. of WO 00/49132

Bone growth transgenics

Hong Kong

Transgenics having a mutated Type X collagen gene; for studying bone growth.

Imperial College Innovations WO 00/49175

Prostate cancer diagnostics

London

Pax 2 gene sequences, encoded protein; for prostate cancer diagnosis and therapy.

Incyte Genomics WO 00/49043

Lipid-associated proteins

Palo Alto, Calif.

Human lipid-associated proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Iowa, Univ. of WO 00/48622

Inhibiting inflammation

Iowa City, Iowa

Administration of microbial or mycobacterial peptides; for inhibiting inflammation.

Isis Innovation WO 00/48631

Immunosuppression

Oxford, UK

Using CD38, fragments, and analogs to inhibit CD38 binding to follicular dendritic cells and cause immunosuppression.

Isis Pharma WO 00/49032

Antisense oligonucleotides

Carlsbad, Calif.

Oligonucleotides having alkylphosphonate linkages, optically pure dimers, preparation methods; for antisense.

Kitamura, T., et al. WO 00/49148

Cytokine receptor family protein

Tokyo

Cytokine receptor-like protein homologous to type I cytokine receptor family, encoding gene sequences.

Kitamura, T., et al. WO 00/49149

TNF receptor family protein

Tokyo

Membrane secretory protein of the TNF receptor family highly expressed in brain and skin, encoding gene sequences.

Leeds, Univ. of WO 00/49167

Herpesvirus gene therapy vectors

Leeds, UK

Latency-associated regulatory gene sequence from herpesvirus saimiri, fragments, variants; for gene therapy vectors.

Ligocyte Pharma WO 00/48633

Yeast infection therapeutic

Bozeman, Mont.

Antibodies to a hydrophobic antigen from the cell wall of Candida yeast strains; for infection treatment.

Mass. Gen. Hosp. WO 00/49035

Gene silencing

Boston

Gene silencing using expression of antisense from a nucleic acid sequence complementary to the gene to be inhibited.

Matsushita Electric EP 1 031 630

Bacteria detection

Osaka, Japan

Detecting bacteria by infecting them with recombinant phage expressing a light-emitting protein.

McMaster Univ. WO 00/49139

Caspase-activated protein kinase

Hamilton, Ont.

Ste20-related kinase that is activated by caspase, encoding gene sequences; for identifying analogs.

Merck WO 00/49039

Protein detection in gels

Darmstadt, Germany

Glucose dehydrogenase fusion proteins; for detection of proteins in SDS-polyacrylamide gels.

Merck WO 00/49166 & 49168

Adenoviral gene therapy vectors

Rahway, N.J.

Making purified adenovirus vectors using site-specific recombinases and endonucleases to reduce helper virus.

Microbiological Res. Auth. WO 00/49176

Ultrasound DNA strand separation

Salisbury, UK

Separation of nucleic acids into single strands using ultrasound; for eliminating temperature cycling in PCR.

Mt. Sinai Hosp. WO 00/49145

Hematopoietic lineage genes

Toronto, Ont.

Genes expressed primarily in hematopoietic lineages, encoded proteins, truncations, analogs, homologs, isoforms.

NIH (Natl. Inst. Hlth.) WO 00/49151

GABAA receptor gene polymorphisms

Bethesda, Md.

Human GABAA receptor a-6 subunit gene polymorphisms, encoded protein with decreased sensitivity to benzodiazepines.

NIH (Natl. Inst. Hlth.) WO 00/49410

Protein fingerprinting

Bethesda, Md.

Protein content and sequence analysis on laser capture microdissected cells; for finding tumor cell differences.

New York State Office Mental Hlth. WO 00/49160

Personality disorder polymorphisms

Albany, N.Y.

Phenylalanine hydroxylase gene variants; for measuring pterin homeostasis and associated personality disorders.

Novartis EP 1 031 628

Hirudin production

Basel, Switzerland

Use of the CUP1 promoter in recombinant yeast strains for producing desulphatohirudin.

Pasteur Inst. WO 00/49174

Sulfonylurea susceptibility

Lille, France

Determining the sequence of the SUR1 gene; for determining the susceptibility of an NIDDM patient to sulfonylureas.

Perkin-Elmer WO 00/49178

Nucleic acid sequencing

Foster City, Calif.

Nucleic acid sequencing using target-specific primers and electrophoretic separation using a sieving matrix.

Pierre Fabre Medicament WO 00/48628 & 48629

Inducing anti-cancer immunoresponse

Boulogne-Billancourt, France

Klebsiella pneumoniae enterobacterium membrane protein antigen; for anti-cancer cytotoxic immune responses.

Promega WO 00/49171

Luciferase detection of cells

Madison, Wis.

Detection of the presence of cells using endogenous enzymes to make ATP that is detected by luciferase.

Promega WO 00/49179-49182

Nucleic acid sequence detection

Madison, Wis.

Depolymerization of nucleic acid hybrids to quantitatively and qualitatively detect the presence of specific sequences.

Qiagen EP 1 031 626

Stabilizing nucleic acids

Hilden, Germany

Methods for isolating and stabilizing nucleic acids by using cation binding; for making probes [in German].

RMF Dictagene WO 00/49146

Malaria vaccine

Prilly, Switzerland

C-terminal peptide of Plasmodium circumsporozite protein in which cysteine residues are oxidized; for vaccines.

Rutgers Univ. WO 00/48632

Redox clamping agents

Piscataway, N.J.

Redox clamping agents that maintain cells at a selected redox state; for sensitizing cells to therapeutic action.

Schubert, U., et al. WO 00/49038

HIV-1 antibodies

Uhlstad, Germany

Synthetic peptides from the regulatory virus protein R of HIV-1, analogs, fragments, antibodies.

Sheffield, Univ. of WO 00/49137

Pluripotent stem cells

Sheffield, UK

Pluripotent stem cells containing cytoplasm from embryonic stem or germ cells and a somatic cell nucleus.

Sheffield, Univ. of WO 00/49138

Pluripotent stem cells

Sheffield, UK

Pluripotent stem cells containing cytoplasm from teratocarcinoma cells and a somatic cell nucleus.

SmithKline Beecham WO 00/49033

Antibacterial screens

Philadelphia

Bacterial yybQ polypeptides, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/49042

Antibacterial screens

Philadelphia

Bacterial nadE polypeptides, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/49154

P101 protein splice variants

Brentford, UK

Splice variants of P101 protein, encoding genes, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/49170

Mouse 11cby receptor

Philadelphia

Mouse 11cby receptor, encoding gene sequences, recombinant production methods; for screening modulators.

Stanford Univ. WO 00/49034

Naked cuticle genes

Palo Alto, Calif.

Naked cuticle genes, encoded proteins; for finding homologs and cell types based on gene expression patterns.

Sugen WO 00/49144

Pyk2 binding proteins

S. San Francisco

Pyk2 binding proteins, encoding gene sequences; for identifying other protein kinase family members.

Sumitomo Electric WO 00/49041

Inducing cell immune response

Osaka, Japan

Fusion of a cytotoxic T cell epitope and the ATPase domain of heat shock protein; for cellular immune responses.

Takeda Chemical WO 00/49046

G protein-coupled receptor

Osaka, Japan

Human G protein-coupled receptor, encoding gene, antibodies; for identifying modulators.

Terumo WO 00/49159

Tissue regeneration biomatrix

Tokyo

Fusion protein having collagen binding and therapeutic moieties; for making tissue regeneration biomatrix.

Theragene Biomed. Labs WO 00/49147

Hormone responsive sequences

Martinsreid, Germany

Hormone responsive gene sequences, hormone-hormone receptor complexes; for gene therapy and vaccine delivery.

U.S. Surgical WO 00/49136

Tissue rejection inhibition

Norwalk, Conn.

Genetically altered mesenchymal cells having a gene encoding an immunosuppressant; for inhibiting tissue rejection.

Virginia, Univ. of WO 00/48620

Yeast infection therapy

Charlottesville, Va.

Yeast cell wall hydrophobic peptides that mediate pathogenesis, antibodies; for infection therapeutics.

ZymoGenetics WO 00/48625

Hemostasis inhibition

Seattle

Proteins with globular and collagen-like domains, encoding genes; for inhibiting hemostasis and immune function.

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