Published June 21 (EP); June 15 (WO); June 21 (GB)

Adv. Res. & Technol. Inst. WO 00/34524

Cell cycle-regulating gene

Indianapolis

Cell cycle-regulating gene related to Drosophila centrosomin proteins; for blocking cell division.

Amgen WO 00/34475

Neurotrophic factor

Thousand Oaks, Calif.

GDNF-related neurotrophic factor expressed in peripheral neurons, encoding gene; for diagnostics and therapeutics.

Antigen Express WO 00/34467

Cancer cell vaccines

Worcester, Mass.

Regulator of Ii protein expression or immunoregulatory function; for cancer cell vaccines.

Astra Pharma WO 00/34333

CNS G protein-coupled receptor

Mississauga, Ont.

G protein-coupled receptor expressed in the CNS, encoding gene; for diagnostics and therapeutics.

Aventis Behring EP 1 010 762

Blood coagulation fusions

Marburg, Germany

DNA constructs encoding fusion of blood clotting factors and the P-selectin cytoplasmic domain; for blood coagulation.

Barnes-Jewish Hosp. WO 00/34458

Bone anabolism model

St. Louis

Transgenics having altered epithelial sodium channel expression in osteoblasts; for studying bone anabolism.

Bayer WO 00/34460

Integrating heterologous genes

Berkeley, Calif.

Vectors having the terminal repeat sequence of Epstein-Barr virus; for improving integration of heterologous genes.

Bayer WO 00/34462

Protein secretion cell fusions

Berkeley, Calif.

Human hybrid cells made from embryonic kidney and lymphoma cells; for increased secretion of heterologous proteins.

Bergbau EP 1 010 756

Pleural mesothelial cells

Bochum, Germany

Mesothelial cells isolated from the visceral pleura and cultured in serum-free medium [in German].

Biomira WO 00/34468

Autoimmunity treatment

Edmonton, Alberta

Protein inhibitors of the mucin MUC-1 that contain a targeting or internalization domain; for autoimmunity.

Breakefield, X.O., et al. WO 00/34497

Herpes virus vectors

Newton, Mass.

Enhanced packaging of herpes virus amplicons; for generating recombinant virus vectors.

CNRS (Natl. Ctr. Sci. Res.) WO 00/34492 & 34493

Epithelial expression transgenes

Paris

Mouse villin gene regulatory sequences; for driving transgene expression in intestinal epithelial cells.

Children's Hosp. WO 00/34484

Pathogenic E. coli identification

Seattle, Wash.

Polymorphic loci that differentiate various strains of E. coli; for diagnosis and therapy of pathogenic infections.

City of Hope WO 00/34495

Transfecting hematopoietic cells

Duarte, Calif.

Transducing primitive quiescent human hematopoietic cells using an adeno-associated viral vector.

Clausen, H. WO 00/34449

Glycosylation enzyme variation

Holte, Denmark

Glycosylation enzymes, encoding gene sequences; for detecting patient enzyme sequence variation.

Clontech Labs WO 00/34318-34326 & 34526

Fluorescent reporter proteins

Palo Alto, Calif.

Fluorescent proteins from non-bioluminescent species from the Class Anthozoa, encoding genes; for use as reporters.

Clontech Labs WO 00/34435

Reporter constructs

Palo Alto, Calif.

Reporter constructs using cis elements; for making reporter vector systems.

Corixa WO 00/34483

Chlamydia infection therapy

Seattle, Wash.

Chlamydia proteins, antigenic fragments, encoding gene sequences; for infection diagnosis and therapy.

Dana-Farber Cancer Inst. WO 00/34309

CD2 binding protein

Boston

Human CD2 cytoplasmic tail binding protein, encoding gene sequences, expression vectors, recombinant host cells.

Devgen WO 00/34438

Finding pharmaceuticals

Zwijnaarde, Belgium

Constructing phenotypic profiles in nematode worms; for identifying compounds with pharmacologic activity.

Eli Lilly WO 00/33635

Hepatitis C inhibitors

Indianapolis

Primer-independent RNA synthesis catalyzed by hepatitis C virus polymerase; for finding hepatitis C inhibitors.

Genetronics WO 00/34436

Chromosomes into cells

San Diego

Introduction of individual chromosomes into cells and sorting of the cells to isolate transduced cells.

Genvec WO 00/34496

Gene expression persistence

Gaithersburg, Md.

Using trans- and cis-activation of genes inserted in adenoviral vectors to modulate expression persistence.

Genzyme WO 00/34500

Efficient gene transfer

Framingham, Mass.

Increased efficiency of transfection in cells surrounded by extracellular matrix (ECM) using ECM degrading enzymes.

Hsu, L.-W., et al. EP 1 010 758

Recombinant human EPO

Taichung City, Taiwan

Expression system for producing recombinant human erythropoietin (EPO), EPO purified by chromatography.

Incyte Genomics WO 00/34477

Neuron-associated proteins

Palo Alto, Calif.

Neuron-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/34464

Protein kinase modulator screens

Paris

Methods for using yeasts to screen protein kinase modulators in human and other eukaryotic cells.

Invitek WO 00/34463

Genetic analysis

Berlin

Isolating nucleic acids by bonding to a solid phase without chaotropes; for subsequent genetic analysis.

Isis Pharma WO 00/34301

G-alpha-11 antisense

Carlsbad, Calif.

Antisense modulation of G-alpha-11 expression; for treating diseases associated with G-alpha-11 expression.

Isis Pharma WO 00/34302

EGR-1 antisense

Carlsbad, Calif.

Antisense modulation of EGR-1 expression; for treating diseases associated with EGR-1 expression.

Isis Pharma WO 00/34303

Cell adhesion modulation

Carlsbad, Calif.

Methods of modulating TNF-a induced expression of cell adhesion molecules using identified inhibitors.

Janssen Pharma WO 00/34481

Yeast infection therapeutics

Beerse, Belgium

Identification of genes critical for growth and cell division in yeast; for treating infections.

Krebs Res. Ctr. WO 00/34472

Spermatogenesis modulation

Heidelberg, Germany

Spermatogenesis protein, encoding gene, antibodies; for influencing spermatogenesis.

Manitoba, Univ. of WO 00/34498

Chamydia infection vaccine

Winnipeg, Manitoba

Chlamydia infection therapy using a Chlamydia protein and attenuated bacteria transfected with a Chlamydia gene.

Mayo Clinic WO 00/34304

Eosinophil-specific expression

Rochester, Minn.

Promoter for eosinophil-specific expression of transgenes, transgenics incorporating such sequences.

Mayo Clinic WO 00/34489

Major basic protein transgenics

Rochester, Minn.

Transgenics having inactivated major basic protein alleles; for therapeutic models.

MRC (Med. Res. Counc.) GB 2 344 886

Intracellular antibodies

London

Selection of antibodies that bind antigens intracellularly by using binding molecules that generate a signal.

Millennium Pharma WO 00/34330

CARK proteins

Cambridge, Mass.

CARK proteins, encoding genes, antisense, antibodies, fusions, transgenics; for diagnostics and therapeutics.

Minnesota, Univ. of WO 00/34487

Streptococcus vaccines

Minneapolis

Immunogenic variant of streptococcal C5a peptidase, encoding gene sequences; for making vaccines.

NIH (Natl. Inst. Hlth.) WO 00/34494

T cell activation

Bethesda, Md.

Recombinant vector expressing multiple co-stimulatory molecules; for enhanced T cell activation.

New York, State Univ. of WO 00/34469

Cell migration alteration

Albany, N.Y.

Alteration of cell migration using clusterin and gp38k or antibodies to them; for treating restenosis.

Novartis WO 00/34455

Diabetes immunotherapy

Basel, Switzerland

Transferring immunoregulatory genes into pancreatic islets ex vivo and into the pancreas in vivo; for diabetes.

Novo Nordisk WO 00/34450

Designing antifungals

Bagsvaerd, Denmark

Variants of fungal cutinases having improved thermostability; for designing antifungal agents.

Oxford BioMedica WO 00/34488

Regulating therapeutic expression

Oxford, UK

Bacterial transcription regulators, linkage of therapeutic genes to the regulator binding site.

Pasteur Inst. EP 1 010 763

Bacterial production system

Paris

Large scale production of heterologous proteins in bacteria using reduced growth temperature and rare tRNA coexpression.

Phylos WO 00/34784

Evolving binding ligands

Lexington, Mass.

Protein scaffolds having a fibronectin type III domain, encoding genes; for evolving binding species and ligands.

Protein Design Labs WO 00/34459

Psoriasis model

Fremont, Calif.

Immunocompromised animals injected with CD45Rb positive cells and stimulated with cytokines; for modeling psoriasis.

Schering WO 00/34335

Mammalian virus genes

Kenilworth, N.J.

Mammalian virus genes, encoded proteins, antibodies; for diagnostics and therapeutics.

Seki, T, et al. WO 00/34490

Therapeutics from plants

Osaka, Japan

Plant cells having transfected human glycosyltransferase genes; for making therapeutics in plants.

Shanghai Biorigin Gene Develop. WO 00/34471

Neural system disorder therapy

Shanghai, China

Human neural system growing-associated genes, encoded proteins; for diagnostics and therapeutics.

Shanghai Second Med. Univ. WO 00/34328

G protein-coupled receptor

Shanghai, China

Human G protein-coupled receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.

Shanghai Second Med. Univ. WO 00/34470

Endoplasmic reticulum ATPase

Shanghai, China

Human transitional endoplasmic reticulum ATPase gene, encoded protein; for diagnostics and therapeutics.

Shionogi WO 00/34486

Secretory phospholipase A2,

Osaka, Japan

Human secretory phospholipase A2, encoding gene sequences; recombinant production methods.

Signal Pharma WO 00/34447

Modulating NFkappaB activation

San Diego

Agents that modulate ubiqination of phosphorylated IkappaBa and IkappaB_; for modulating activation of NFkappaB.

SmithKline Beecham WO 00/34480

Meningitis vaccines

Rixensart, Belgium

Neisseria meningitidis proteins, encoding genes, recombinant production methods; for meningitis vaccines.

SmithKline Beecham WO 00/34482

Therapeutic proteins

Rixensart, Belgium

Proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

Stressgen Biotech WO 00/34465

Immune responses to pathogens

Victoria, B.C.

Heat shock genes for bacterial, fungal, and yeast pathogens, encoded proteins; for generating immune responses.

Synaptic Pharma WO 00/34334

Mammalian receptor

Paramus, N.J.

Mammalian receptor fb41a, encoding gene, antibodies, variants, transgenics; for diagnostics and therapeutics.

Takara Shuzo EP 1 010 761

Modifying polysaccharides

Kyoto, Japan

Sulfated fucose-containing polysaccharide degrading protein, encoding gene; for modifying polysaccharides.

Takara Shuzo WO 00/34456

Immobilizing DNA

Kyoto, Japan

Methods for immobilizing DNA onto a carrier using morpholine derivatives.

Takara Shuzo WO 00/34457

Immobilizing oligos

Kyoto, Japan

Methods for immobilizing oligonucleotides onto a carrier via a covalent bond.

Takeda Chemical WO 00/34478

Diabetes therapeutics

Osaka, Japan

Betacellulin mutein having reduced EGF activity and less antigenicity; for diabetes therapeutics.

Tamura, R. EP 1 010 759

Hepatitis detection

Saitama, Japan

Non-B, non-C, non-G hepatitis virus gene, encoded protein, assembled virion; for virus detection.

Texas, Univ. of WO 00/34461

Cholesterol metabolism modulation

Austin, Texas

Agents affecting cholesterol absorption, bile acid synthesis enhancer screens; for modulating cholesterol metabolism.

Toagosei WO 00/34337

Humanized VEGF antibodies

Ibaraki, Japan

Humanized monoclonal antibodies against vascular endothelial growth factor (VEGF).

Transgene WO 00/34499

Macropinocyte transfection

Strasbourg, France

Immunocomplex having an antibody and a gene sequence; for transfecting macropinocytotic cells.

Univ. College WO 00/34466

Cervical cancer treatment

London

Agents that decrease intracellular Brn-3a; for diagnosis and treatment of papillomavirus-associated cervical cancer.

Vanderbilt Univ. WO 00/34310

TGF-_ signal modulators

Nashville, Tenn.

Serine-threonine kinase receptors associated protein involved in TGF-_ signal transduction, encoding gene.

Washington State Univ. WO 00/34439

Desaturases

Pullman, Wash.

Desaturases, encoding gene sequences; for transfecting cells to produce polyunsaturated fatty acids.

Women's & Children's Hosp. WO 00/34327

Human sulfatases

North Adelaide, Australia

Human sulfatases, variants, derivatives, encoding gene sequences, probes.

ZymoGenetics WO 00/34473

CNS disease receptor

Seattle, Wash.

Seven transmembrane domain receptor, encoding gene, antibodies; for CNS and reproductive disease.

ZymoGenetics WO 00/34474

Growth factor homolog

Seattle, Wash.

Growth factor homolog, encoding gene, antibodies; for regulating cell and tissue development.

ZymoGenetics WO 00/34485

Glycoprotein synthesis modulators

Seattle, Wash.

Galactosyltraneferase homologs, encoding gene sequences, antibodies; for modulating glycoprotein synthesis.

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