Published June 21 (EP); June 15 (WO); June 21 (GB)
Adv. Res. & Technol. Inst. WO 00/34524
Cell cycle-regulating gene
Cell cycle-regulating gene related to Drosophila centrosomin proteins; for blocking cell division.
Amgen WO 00/34475
Thousand Oaks, Calif.
GDNF-related neurotrophic factor expressed in peripheral neurons, encoding gene; for diagnostics and therapeutics.
Antigen Express WO 00/34467
Cancer cell vaccines
Regulator of Ii protein expression or immunoregulatory function; for cancer cell vaccines.
Astra Pharma WO 00/34333
CNS G protein-coupled receptor
G protein-coupled receptor expressed in the CNS, encoding gene; for diagnostics and therapeutics.
Aventis Behring EP 1 010 762
Blood coagulation fusions
DNA constructs encoding fusion of blood clotting factors and the P-selectin cytoplasmic domain; for blood coagulation.
Barnes-Jewish Hosp. WO 00/34458
Bone anabolism model
Transgenics having altered epithelial sodium channel expression in osteoblasts; for studying bone anabolism.
Bayer WO 00/34460
Integrating heterologous genes
Vectors having the terminal repeat sequence of Epstein-Barr virus; for improving integration of heterologous genes.
Bayer WO 00/34462
Protein secretion cell fusions
Human hybrid cells made from embryonic kidney and lymphoma cells; for increased secretion of heterologous proteins.
Bergbau EP 1 010 756
Pleural mesothelial cells
Mesothelial cells isolated from the visceral pleura and cultured in serum-free medium [in German].
Biomira WO 00/34468
Protein inhibitors of the mucin MUC-1 that contain a targeting or internalization domain; for autoimmunity.
Breakefield, X.O., et al. WO 00/34497
Herpes virus vectors
Enhanced packaging of herpes virus amplicons; for generating recombinant virus vectors.
CNRS (Natl. Ctr. Sci. Res.) WO 00/34492 & 34493
Epithelial expression transgenes
Mouse villin gene regulatory sequences; for driving transgene expression in intestinal epithelial cells.
Children's Hosp. WO 00/34484
Pathogenic E. coli identification
Polymorphic loci that differentiate various strains of E. coli; for diagnosis and therapy of pathogenic infections.
City of Hope WO 00/34495
Transfecting hematopoietic cells
Transducing primitive quiescent human hematopoietic cells using an adeno-associated viral vector.
Clausen, H. WO 00/34449
Glycosylation enzyme variation
Glycosylation enzymes, encoding gene sequences; for detecting patient enzyme sequence variation.
Clontech Labs WO 00/34318-34326 & 34526
Fluorescent reporter proteins
Palo Alto, Calif.
Fluorescent proteins from non-bioluminescent species from the Class Anthozoa, encoding genes; for use as reporters.
Clontech Labs WO 00/34435
Palo Alto, Calif.
Reporter constructs using cis elements; for making reporter vector systems.
Corixa WO 00/34483
Chlamydia infection therapy
Chlamydia proteins, antigenic fragments, encoding gene sequences; for infection diagnosis and therapy.
Dana-Farber Cancer Inst. WO 00/34309
CD2 binding protein
Human CD2 cytoplasmic tail binding protein, encoding gene sequences, expression vectors, recombinant host cells.
Devgen WO 00/34438
Constructing phenotypic profiles in nematode worms; for identifying compounds with pharmacologic activity.
Eli Lilly WO 00/33635
Hepatitis C inhibitors
Primer-independent RNA synthesis catalyzed by hepatitis C virus polymerase; for finding hepatitis C inhibitors.
Genetronics WO 00/34436
Chromosomes into cells
Introduction of individual chromosomes into cells and sorting of the cells to isolate transduced cells.
Genvec WO 00/34496
Gene expression persistence
Using trans- and cis-activation of genes inserted in adenoviral vectors to modulate expression persistence.
Genzyme WO 00/34500
Efficient gene transfer
Increased efficiency of transfection in cells surrounded by extracellular matrix (ECM) using ECM degrading enzymes.
Hsu, L.-W., et al. EP 1 010 758
Recombinant human EPO
Taichung City, Taiwan
Expression system for producing recombinant human erythropoietin (EPO), EPO purified by chromatography.
Incyte Genomics WO 00/34477
Palo Alto, Calif.
Neuron-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/34464
Protein kinase modulator screens
Methods for using yeasts to screen protein kinase modulators in human and other eukaryotic cells.
Invitek WO 00/34463
Isolating nucleic acids by bonding to a solid phase without chaotropes; for subsequent genetic analysis.
Isis Pharma WO 00/34301
Antisense modulation of G-alpha-11 expression; for treating diseases associated with G-alpha-11 expression.
Isis Pharma WO 00/34302
Antisense modulation of EGR-1 expression; for treating diseases associated with EGR-1 expression.
Isis Pharma WO 00/34303
Cell adhesion modulation
Methods of modulating TNF-a induced expression of cell adhesion molecules using identified inhibitors.
Janssen Pharma WO 00/34481
Yeast infection therapeutics
Identification of genes critical for growth and cell division in yeast; for treating infections.
Krebs Res. Ctr. WO 00/34472
Spermatogenesis protein, encoding gene, antibodies; for influencing spermatogenesis.
Manitoba, Univ. of WO 00/34498
Chamydia infection vaccine
Chlamydia infection therapy using a Chlamydia protein and attenuated bacteria transfected with a Chlamydia gene.
Mayo Clinic WO 00/34304
Promoter for eosinophil-specific expression of transgenes, transgenics incorporating such sequences.
Mayo Clinic WO 00/34489
Major basic protein transgenics
Transgenics having inactivated major basic protein alleles; for therapeutic models.
MRC (Med. Res. Counc.) GB 2 344 886
Selection of antibodies that bind antigens intracellularly by using binding molecules that generate a signal.
Millennium Pharma WO 00/34330
CARK proteins, encoding genes, antisense, antibodies, fusions, transgenics; for diagnostics and therapeutics.
Minnesota, Univ. of WO 00/34487
Immunogenic variant of streptococcal C5a peptidase, encoding gene sequences; for making vaccines.
NIH (Natl. Inst. Hlth.) WO 00/34494
T cell activation
Recombinant vector expressing multiple co-stimulatory molecules; for enhanced T cell activation.
New York, State Univ. of WO 00/34469
Cell migration alteration
Alteration of cell migration using clusterin and gp38k or antibodies to them; for treating restenosis.
Novartis WO 00/34455
Transferring immunoregulatory genes into pancreatic islets ex vivo and into the pancreas in vivo; for diabetes.
Novo Nordisk WO 00/34450
Variants of fungal cutinases having improved thermostability; for designing antifungal agents.
Oxford BioMedica WO 00/34488
Regulating therapeutic expression
Bacterial transcription regulators, linkage of therapeutic genes to the regulator binding site.
Pasteur Inst. EP 1 010 763
Bacterial production system
Large scale production of heterologous proteins in bacteria using reduced growth temperature and rare tRNA coexpression.
Phylos WO 00/34784
Evolving binding ligands
Protein scaffolds having a fibronectin type III domain, encoding genes; for evolving binding species and ligands.
Protein Design Labs WO 00/34459
Immunocompromised animals injected with CD45Rb positive cells and stimulated with cytokines; for modeling psoriasis.
Schering WO 00/34335
Mammalian virus genes
Mammalian virus genes, encoded proteins, antibodies; for diagnostics and therapeutics.
Seki, T, et al. WO 00/34490
Therapeutics from plants
Plant cells having transfected human glycosyltransferase genes; for making therapeutics in plants.
Shanghai Biorigin Gene Develop. WO 00/34471
Neural system disorder therapy
Human neural system growing-associated genes, encoded proteins; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 00/34328
G protein-coupled receptor
Human G protein-coupled receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 00/34470
Endoplasmic reticulum ATPase
Human transitional endoplasmic reticulum ATPase gene, encoded protein; for diagnostics and therapeutics.
Shionogi WO 00/34486
Secretory phospholipase A2,
Human secretory phospholipase A2, encoding gene sequences; recombinant production methods.
Signal Pharma WO 00/34447
Modulating NFkappaB activation
Agents that modulate ubiqination of phosphorylated IkappaBa and IkappaB_; for modulating activation of NFkappaB.
SmithKline Beecham WO 00/34480
Neisseria meningitidis proteins, encoding genes, recombinant production methods; for meningitis vaccines.
SmithKline Beecham WO 00/34482
Proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
Stressgen Biotech WO 00/34465
Immune responses to pathogens
Heat shock genes for bacterial, fungal, and yeast pathogens, encoded proteins; for generating immune responses.
Synaptic Pharma WO 00/34334
Mammalian receptor fb41a, encoding gene, antibodies, variants, transgenics; for diagnostics and therapeutics.
Takara Shuzo EP 1 010 761
Sulfated fucose-containing polysaccharide degrading protein, encoding gene; for modifying polysaccharides.
Takara Shuzo WO 00/34456
Methods for immobilizing DNA onto a carrier using morpholine derivatives.
Takara Shuzo WO 00/34457
Methods for immobilizing oligonucleotides onto a carrier via a covalent bond.
Takeda Chemical WO 00/34478
Betacellulin mutein having reduced EGF activity and less antigenicity; for diabetes therapeutics.
Tamura, R. EP 1 010 759
Non-B, non-C, non-G hepatitis virus gene, encoded protein, assembled virion; for virus detection.
Texas, Univ. of WO 00/34461
Cholesterol metabolism modulation
Agents affecting cholesterol absorption, bile acid synthesis enhancer screens; for modulating cholesterol metabolism.
Toagosei WO 00/34337
Humanized VEGF antibodies
Humanized monoclonal antibodies against vascular endothelial growth factor (VEGF).
Transgene WO 00/34499
Immunocomplex having an antibody and a gene sequence; for transfecting macropinocytotic cells.
Univ. College WO 00/34466
Cervical cancer treatment
Agents that decrease intracellular Brn-3a; for diagnosis and treatment of papillomavirus-associated cervical cancer.
Vanderbilt Univ. WO 00/34310
TGF-_ signal modulators
Serine-threonine kinase receptors associated protein involved in TGF-_ signal transduction, encoding gene.
Washington State Univ. WO 00/34439
Desaturases, encoding gene sequences; for transfecting cells to produce polyunsaturated fatty acids.
Women's & Children's Hosp. WO 00/34327
North Adelaide, Australia
Human sulfatases, variants, derivatives, encoding gene sequences, probes.
ZymoGenetics WO 00/34473
CNS disease receptor
Seven transmembrane domain receptor, encoding gene, antibodies; for CNS and reproductive disease.
ZymoGenetics WO 00/34474
Growth factor homolog
Growth factor homolog, encoding gene, antibodies; for regulating cell and tissue development.
ZymoGenetics WO 00/34485
Glycoprotein synthesis modulators
Galactosyltraneferase homologs, encoding gene sequences, antibodies; for modulating glycoprotein synthesis.