Published July 28 (EPO); July 22 (WO); July 28 (GB)
Abbott Labs WO 99/36539
Human purinoreceptor P2X3
Abbott Park, Ill.
Human purinoreceptor P2X3, encoding gene sequences, production methods; for screening modulators.
Abbott Labs WO 99/36784
Apolipoprotein domain antibodies
Abbott Park, Ill.
Specific antibodies to apolipoprotein kringle 5; for diagnostics and therapeutics.
Abbott Labs WO 99/36785
VLDL assay
Abbott Park, Ill.
Use of a specific very low density lipoprotein binding (VLDL) agent to assay VLDL and associated cholesterol.
Adv. Res. & Technol. Inst. WO 99/36093
Immunosuppression
Bloomington, Ind.
Activation of T cell responses by using the H4-1BB receptor and its ligand; for immunosuppression.
Agrobiogen WO 99/35906 & 36510
Producing transgenic embryos
Hilgertshausen, Germany
Transgenic embryo production using efficient transfer of nuclei from primordial germ cells and fetal fibroblasts.
Ajinomoto EPO 931 833
Serine production
Tokyo
Coryneform bacteria having inserted genes encoding feedback desensitized L-serine biosynthetic enzymes; for production.
Ariad Gene Therapeutics WO 99/36553
Gene transcription regulation
Cambridge, Mass.
Regulation of target gene transcription and engineered cell growth using multimeric chimeric proteins.
Aurx WO 99/36513
Herpes gene therapy vector
Baltimore
Replication defective herpes virus having a deleted ribonucleotide reductase gene; for gene therapy vectors.
Barcelona, Free Univ. of EPO 931 832
Metalocarboxypeptidase inhibitors
Bellaterra, Spain
Metalocarboxypeptidase inhibitors, natural and engineered variants, peptidomimetics; for cancer therapy.
BASF WO 99/36432
Uracil auxotrophs
Ludwigshafen, Germany
Gene encoding orotidine 5'-phosphate decarboxylase, homologs; for introduction into uracil auxotrophs.
Bio-Discovery WO 99/36439
Factor XII activation inhibitors
Pontardulais, UK
Leech polypeptides that inhibit C1 esterase and/or Factor XII activation, encoding gene sequences; for therapeutics.
Biosource Technol. WO 99/36516
Function determination
Vacaville, Calif.
Determination of gene and encoded protein function by transfection into hosts and observing phenotype change.
Biotecon WO 99/36515
Isolating metabolic activities
Berlin
Isolation of new metabolic activities in microorgansims by allowing gene transfer into easily transfected hosts.
Blood Ctr. Res. Fdn. WO 99/36536
PL scramblase expression modulation
Milwaukee
Methods for altering normal and cancerous cell viability by modulating the expression of native PL scramblase.
BRAHMS Diagnostica WO 99/36552
TSH autoantibodies
Berlin
Solid phase purification of thyroid stimulating hormone (TSH) receptor; for analyzing TSH autoantibodies.
Bristol, Univ. of WO 99/36440
Fusion protein therapeutics
Bristol, UK
Fusion proteins containing antibody and biologically active domains, encoding viral vectors; for gene therapy.
BTG Intl. WO 99/36518
CCR5/CXCR4 ribozymes
London
Ribozymes that cleave CCR5 or CXCR4 encoding gene; for affecting HIV infection.
California, Univ. of WO 99/36079
Noncleavable Fas ligand
Oakland, Calif.
Noncleavable forms of the Fas ligand; for activating the Fas receptor-mediated cell death pathway.
Calif. Pacific Med. Ctr. WO 99/36514
Non-viral gene delivery
San Francisco, Calif.
Efficient, optimized non-viral gene delivery; for gene therapy and functional analysis of cloned gene products.
Centeon Pharma EPO 931 793
Factor VII antibodies
Marburg, Germany
Monoclonal antibody specific for the activated form of coagulation Factor VII; for therapeutics [in German].
Ctr. Molec. Med. & Immunol. WO 99/36437
Cellular ligand delivery
Belleville, N.J.
Antibody targeting moieties used with cytokine receptor ligand binding domains and therapeutic agents.
CNRS (Natl. Ctr. Sci. Res.) WO 99/36561
Improved viral fusion
Paris
Proline-rich sequences of murine leukemia virus envelope glycoprotein; for improved viral fusion.
Chiron WO 99/35907
Ulcer animal model
Siena, Italy
Animal model for acute Helicobacter pylori infection; for ulcer diagnostics, therapeutics, and vaccines.
Chiron WO 99/36511
FIV gene therapy vectors
Emeryville, Calif.
Gene therapy vectors based on feline immunodeficiency virus (FIV), packaging cells; for diagnostics and therapeutics.
Chiron WO 99/36544
Neisseria vaccines
Siena, Italy
Neisseria meningitidis antigenic proteins, encoding gene sequences; for diagnostics, therapeutics, and vaccines.
Codon Diagnostics WO 99/36540
Breast chemokine
Amherst, N.Y.
Human chemokine preferentially expressed in breast tissue and found in milk, antibodies, encoding gene sequences.
CSIRO (Comm. Sci. & Res. Org. WO 99/36520
Inscecticidal agents
Campbell, Australia
Genes encoding steroid and juvenile hormone receptors; for screening active insecticidal agents.
Cytel WO 99/36555
Fucosylated oligosaccharide synthesis
San Diego
Enzymatic conversion of GDP-mannose to GDP-fucose; for synthesis of fucosylated oligosaccharides.
Dana-Farber Cancer Inst. WO 99/36534
CD2 cytoplasmic tail binding protein
Boston, Mass.
Human CD2 cytoplasmic tail binding protein, encoding gene sequences; for diagnostics and therapeutics.
Dana-Farber Cancer Inst. WO 99/36783
Melanoma diagnosis
Boston
Diagnosing malignant melanoma by using microphthalmia in the cell nucleus.
Du Pont WO 99/36551
Phosphoglucomutase homologs
Wilmington, Del.
Plant phosphoglucomutase homologs, encoding gene sequences, antisense; for reducing expression of this enzyme in plants.
Emed WO 99/36563
Electrically-aided gene delivery
St. Paul, Minn.
Electrically-aided gene transfection; for increased cellular expression in gene therapy protocols.
Genentech WO 99/36535
Apo-2 ligand cytokine
S. San Francisco
Apo-2 ligand cytokine, chimeras, encoding gene sequences, antibodies; for inducing cancer cell apoptosis.
Genetics Inst. WO 99/36512
Secreted proteins
Cambridge, Mass.
Secreted proteins, encoding gene sequences; for diagnostics and therapeutics.
Genitrix WO 99/36507
Immunomodulatory proteins
Cambridge, Mass.
Immunomodulatory fusion proteins with antigen and antigen presenting cell binding domain moieties, encoding gene.
Genzyme WO 99/36545
Adenoviral vectors
Framingham, Mass.
Adenoviral vectors having capsid proteins with heterologous ligands that modify infectivity; for transgene delivery.
Genzyme WO 99/36557
Persistent transgene expression
Framingham, Mass.
Cytomegalovirus intermediate early promoter, adenoviral vectors; for persistent transgene expression.
Glaxo WO 99/36546
Macrolide synthesis
Greenford, UK
Extended polyketide synthase gene assembly modules; for synthesizing macrolides of larger size than natural agents.
HSC Res. & Develop. WO 99/36548
Lymphoid protein tyrosine phosphatases
Toronto, Ont.
Human lymphoid protein tyrosine phosphatases, encoding genes, production methods.
Human Genome Sciences WO 99/36565
Human ependymin
Rockville, Md.
Human ependymin, encoding gene sequences; for screening modulators and diagnosing nervous system-related disorders.
Human Gene Therapy Res. WO 99/36519
Xeroderma therapy
Des Moines, Iowa
Synthetic human suppressor tRNA oligonucleotides; for gene therapy of Xeroderma pigmentosum.
Human Gene Therapy Res. WO 99/36562
Reduced viral vector immunoresponse
Des Moines, Iowa
Reduced immune responses to viral and non-viral gene delivery methods using immunosuppressive genes in vectors.
Hunan Med. Univ. WO 99/36527
Ataxin-2 like gene
Hunan, China
Ataxin-2 like gene, encoded protein, production methods; for diagnostics and therapeutics.
Hyseq WO 99/36567
Identifying mutations
Sunnyvale, Calif.
Enhanced discrimination of DNA mismatches from perfect matches using a modified DNA ligase; for mutation analysis.
Illinois, Univ. of WO 99/36569
Surface protein display
Urbana, Ill.
Yeast cell surface display of proteins; for fluorescent detection of T cell receptor binding proteins.
Immunex WO 99/36549
Testis-specific proteinase
Seattle
Testis-specific human SVPH1-8 proteinase, encoding gene sequences; for diagnostics and therapeutics.
Incyte Pharma WO 99/36550
Human proteases
Palo Alto, Calif.
Human proteases, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Inst. Molec. Agrobiol. WO 99/36542
Mitogen-activated protein
Singapore
Rice mitogen-activated protein, encoding gene, vectors; for conferring disease-resistance in plants.
Jenne, A. WO 99/36517
Ribonuclease-resistant antisense
Rimating, Germany
Ribozymes that can covalently modify 2'-OH groups on RNA; for producing ribonuclease-resistant antisense.
Julien, J.-P., et al. WO 99/36558-36560
Neural disease gene therapy
Montreal
Viral vectors encoding neural intermediate filament, light, and heavy proteins; for gene therapy in neural diseases.
Kern, F. WO 99/36568
T cell immunostimulation
Berlin
Identification of T cell stimulating protein fragments, synthetic production; for immunostimulation.
Krebs Res. Inst. WO 99/36528
p53 transgenics
Heidelberg, Germany
Transgenics made using embryonic stem cells transfected with p53 gene sequences; for testing p53 modulators.
LG Chemical WO 99/36547
Polyhydroxyalkanoate production
Seoul, S. Korea
Polyhydroxyalkanoate biosynthesis-related genes derived from Alcaligenes latus; for synthesis and production.
Lilly EPO 931 834
Antifungal screen
Indianapolis, Ind.
1,3-_-glucan synthase domain that binds echinocandins, encoding gene sequences; for finding antifungal compounds.
Luminex WO 99/36564
Multiplexed clinical diagnostics
Austin, Texas
Multiplexed analysis of clinical specimens using flow cytometry on labelled beads; for diagnostics.
Mass. Inst. Technol. WO 99/36538
Cardiac rhythm control
Cambridge, Mass.
Molecularly-mediated and cellular-based _-adrenergic receptor-dependent biological pacemakers.
Mayo Clinic WO 99/36574
Gene mutation detection
Rochester, Minn.
Gene amplification methods resulting in stable branched structures when gene mutations are present.
McGill Univ. WO 99/36103
Preventing axonal degeneration
Montreal, Que.
Prevention of axonal degeneration and promotion of axonal growth or regeneration by hepatocyte growth factor.
Med. & Biol. Labs WO 99/36532
Acetyltransferase modulators
Aichi, Japan
Detection of acetyltransferase and deacetylase activities; for screening modulating agents.
Mercy, Sisters of WO 99/36438
IgM binding receptor
S. Brisbane, Australia
Human CMRF-35-H9 receptor which binds immunoglobulin (Ig)-M; for immunomodulation in transplant patients.
Mitsui Chemicals EPO 931 837
Phytase production
Tokyo
Yeast transformants having a phytase gene linked to a methanol-inducible promoter; for phytase secretion.
Mogam Biotech. Res. Inst. WO 99/36424
Hepatitis B therapy
Kyonggi-do, S. Korea
Liposomes containing X protein antigens from hepatitis B virus; for inducing cytotoxic T cells and immunity.
Morphogenesis WO 99/36433
Superantigen cancer therapy
Alachua, Fla.
Superantigens expressed in transfected tumor cells, encoding genes; for cancer therapy.
Myriad Genetics WO 99/36566
Tumor growth suppressor
Salt Lake City
MMSC1, an MMAC1-interacting protein, encoding gene; for detecting protein mutants and suppressing tumor growth.
Nebraska, Univ. of GB 2 333 597
Point mutation detection
Lincoln, Neb.
Detecting point mutations by fluorescence resonance energy transfer caused by non-hybridized base pairs.
Netherlands Inst. WO 99/36556
Alanine production
Ede, Netherlands
Microorganisms having their sugar metabolism diverted to alanine formation; for alanine production.
New England BioLabs EPO 931 835
PmeI endonuclease
Beverly, Mass.
Recombinant DNA encoding PmeI restriction endonuclease and modification methylase; production methods.
New Mexico, Univ. of WO 99/36102
Manipulating mRNA function
Albuquerque, N.M.
Use of 3' untranslated mRNA sequences to alter mRNA function and find binding proteins for these mRNA regions.
Onyx Pharma EPO 931 830
Viral cancer killing
Richmond, Calif.
Cytopathic virus constructs lacking viral proteins that bind or inactivate p53 and RB; for cancer cell specific killing.
Oxford BioMedica GB 2 333 527
Parkinson's gene therapy
Oxford, UK
Therapeutic genes inserted into vectors such that a fusion protein is produced; for Parkinson's disease gene therapy.
Pharmacia & Upjohn WO 99/36554
Pathogenic gene assay
Kalamazoo, Mich.
Regulating endogenous bacterial genes using tetracycline regulatory elements; for finding pathogenic genes.
Pioneer Hi-Bred WO 99/36543
Fungus-resistant plants
Des Moines, Iowa
Hm2 cDNA, encoded protein, antibodies, vectors, transgenic plants; for creating fungus-resistant plants.
Sanofi-Synthelabo WO 99/36529
Potassium channel
Paris
Two P domain potassium channel, encoding gene sequences, production methods; for neural disease diagnostics.
Schichman, S.A., et al. WO 99/36573
Semiconductor gene detection
Little Rock, Ark.
Semiconductor device for detecting DNA hybridization using electron transfer through DNA strands.
Shanghai Second Med. Univ. WO 99/36435
RNA polymerase I-related gene
Shanghai, China
RNA polymerase-I subunit hRPA39-related gene sequences, encoded polypeptides; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/36521
Infertility therapeutics
Shanghai, China
Fox sperm acrosomal protein gene homolog, encoded protein; for diagnosing and treating infertility.
Shanghai Second Med. Univ. WO 99/36522
Tropomyosin homolog
Shanghai, China
Tropomyosin gene homolog, encoded protein, production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/36523
Rat Golgi V-Snare homolog
Shanghai, China
Rat Golgi V-Snare gene homolog, encoded protein, production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/36524
Ribosomal protein L33 homolog
Shanghai, China
Ribosomal protein L33 gene homolog, encoded protein, production methods; for diagnostics and therapeutics.
Shanghai Second Med. Univ. WO 99/36525
Ubiquinone oxireductase homolog
Shanghai, China
Cow ubiquinone oxireductase complex gene homolog, encoded protein, production methods; for therapeutics.
Shanghai Second Med. Univ. WO 99/36526
F1F0-ATP synthase homolog
Shanghai, China
Cow F1F0-ATP synthase complex F0 membrane domain F-subunit gene homolog, encoded protein; for diagnostics.
SmithKline Beecham WO 99/36508
Antibacterial screens
Philadelphia
Histidine kinase polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline Beecham WO 99/36541
IL-1 receptor antagonist _
Philadelphia
Interleukin (IL)-1 receptor antagonist _, encoding gene sequences; for treating immune diseases.
Southern California, Univ. of EPO 931 836
IL-2 vasoactive peptide
Los Angeles
Vasopermeability enhancing peptide fragments of human interleukin (IL)-2, immunoconjugates; for therapeutics.
Valigene WO 99/36575
Molecular phenotyping
New York
Nucleic acid mismatch binding protein chromatography; for comparing gene sequences and molecular phenotypes.
Victoria, Univ. of WO 99/36778
GPI-anchored protein assay
Victoria, B.C.
Assaying GPI-anchored proteins using specifically binding toxins; for detecting paroxysmal nocturnal hemoglobinuria.
Virginia, Univ. of WO 99/36101
Smooth muscle cell myosin promoter
Charlottesville, Va.
Identification of a smooth muscle cell-specific myosin heavy chain promoter and enhancer; for transgenic knockouts.
Washington Univ. WO 99/36436
FAS mRNA binding protein
St. Louis
Fatty acid synthase (FAS) mRNA binding protein, encoding gene sequences; for regulating lipoprotein secretion.
Whitehead Inst. Biomed. Res. WO 99/36537
Fatty acid transport proteins
Cambridge, Mass.
Fatty acid transport proteins, encoding gene sequences; for identifying inhibitors and affecting fatty acid transport.
Wilex Biotechnol. WO 99/36530
LH gene receptor promoter
Munich, Germany
Luteinizing hormone (LH) receptor gene promoter; for tissue-specific gene expression in ovarian-derived cells.
Zeneca WO 99/36531
Human lymph node GTPase
London
Lymph node GTPase, encoding gene sequence; for affecting endothelial cell organization and cytoskeletal organization.
Ziekenhuis Acad. WO 99/36533
Cholestasis associated gene mutations
Utrecht, Netherlands
Mutated gene associated with benign recurrent intrahepatic cholestasis, fragments; for diagnostics.
- Compiled by Chester A. Bisbee