European Patent Disclosures
Published August 13 & 20 (EPO); August 7 & 14 (WO)
Abbott Labs WO 97/29199 Peptides detecting PSA Abbott Park, Ill. Peptides for use in the detection of free and complexed prostate-specific antigen (PSA); for diagnosis.
Amgen EPO 790 306 TNF inhibitors Boulder, Colo. Glycoprotein inhibitors of tumor necrosis factor (TNF) that are derived from urine, production methods.
BASF WO 97/29131 TNF- antibodies Ludwigshafen, Germany Human antibodies against tumor necrosis factor (TNF)-, fragments, encoding genes; for therapeutics.
BASF WO 97/29198 Thrombin antidotes Ludwigshafen, Germany Thrombin muteins, encoding genes; for therapeutic use as antidotes to thrombin treatment.
Bayer EPO 789 032 Sandwich immunoassay antibodies Pittsburg. Monoclonal antibodies that bind equally to free and complexed analyte in a sandwich immunoassay.
Bionebraska WO 97/29127 Calcitonin fragment production Lincoln, Neb. Preparation of calcitonin fragments from fusions with carbonic anhydrase.
Boehringer Mannheim WO 97/27871 Ras protein inactivation Mannheim, Germany Use of a Clostridium toxin-based immunotoxin to inactivate Ras proteins by glycosylation.
Brigham & Women's Hosp. WO 97/27873 Neutrophil migration inhibition Boston Monoclonal antibodies inhibiting CD47-mediated neutrophil migration across cell layers; for modifying immune response.
California, Univ. of WO 97/27865 Prolactin antagonists Oakland, Calif. Prolactin peptides with phosphorylated and substituted residues; for use as antagonists.
California, Univ. of WO 97/28259 Immunostimulatory vectors Oakland, Calif. Gene expression vectors with immunostimulatory polynucleotides; for generating antigen-specific immune responses.
California, Univ. of WO 97/28261 Fluorescent reporter assays Oakland, Calif. Tandem fluorescent protein constructs whose resonance transfer energy is eliminated upon cleavage; for enzyme assays.
Cheng, P.W. WO 97/28817 Gene delivery system Omaha, Neb. Transfection system containing cationic lipids and receptor ligands; for intracellular gene delivery.
Desjardins, L. WO 97/29130 Apoptosis antibodies Gloucester, Ontario Antibodies against apoptosis-related glycoproteins; for detection and control of apoptosis.
Enirecerche EPO 789 078 Engineered peptide synthetases Milan, Italy Construction of functional engineered peptide synthetases; for non-ribosomal production of modified peptides.
Florida, Univ. of WO 97/28262 Chediak-Higashi yndrome genes Gainesville, Fla. Genes associated with Chediak-Higashi yndrome, encoded proteins, antibodies; for diagnosis and therapy.
Fujisawa Pharma WO 97/28684 Hypertension animal model Osaka, Japan Transgenic rat model for hypertension overexpressing renin and angiotensin genes; for identifying therapeutics.
Genentech WO 97/28266 Modified DNase S. San Francisco Modified DNase that is not inhibited by actin, encoding gene; for therapeutics.
Gist-Brocades EPO 790 307 Interleukin-3 Delft, Netherlands Gene for human interleukin (IL)-3, encoded protein, expression systems for impurity-free IL-3 production.
Harvard Univ. WO 97/29209 Chimeric DNA polymerase Cambridge, Mass. Chimeric DNA polymerase with normal polymerase and non-naturally occurring processivity factor binding domains.
Hoechst EPO 790 312 Target cell-specific vectors Frankfurt, Germany Target cell-specific vectors; for the insertion of foreign genes into cells [in German].
Hoechst EPO 790 313 Cell cycle expression regulation Frankfurt, Germany Expression vectors with cell cycle regulation elements; for expression controlled by the cell cycle [in German].
Hoffmann-La Roche EPO 790 255, 308, & 309 Cytotoxic lymphocyte maturation factor Basel, Switzerland Gene for cytotoxic lymphocyte maturation factor, encoded protein, antibodies, production methods; for therapeutics.
HSC Res. & Develop. WO 97/28260 Skin antifreeze proteins Toronto, Ontario Genes for skin intracellular antifreeze proteins from winter flounder, encoded proteins; for cold-resistance.
Human Genome Sciences WO 97/29189 Neuronal attachment factor-1 Rockville, Md. Gene for human neuronal attachment factor-1, encoded protein; for treating spinal chord injuries.
Invitek WO 97/28171 Simultaneous DNA/RNA isolation Berlin Method and device for the simultaneous isolation of genomic DNA and high-purity total RNA.
JCR Pharma EPO 790 305 Mutant growth hormones Hyogo, Japan Mutant growth hormones with reduced biological activity, but same receptor affinity; for use as antagonists.
Lubitz, W. et al. WO 97/28263 S-layer proteins Vienna, Austria Genes for S-layer proteins, encoded proteins, modified proteins, production methods in gram-negative hosts.
Mardh, S. WO 97/29185 Ulcer treatment Vreta Kloster, Sweden Recombinant bacterial phages for inhibition of Helicobacter pylori growth; for treating ulcers.
Massachusetts, Univ. Med. Ctr. WO 97/28265 Measles vaccine Worcester, Mass. Expression vector with gene coding for measles antigen; for immunization.
Max Delbruck Ctr. Molec. Med. WO 97/29201 Multiple myeloma treatment Berlin Retroviral vector with interleukin (IL)-6 antagonist gene; for transfecting stem cells to treat multiple myeloma.
Mogam Biotech. Res. Inst. WO 97/28264 Ulcer therapeutics Kyonggi-do, S. Korea Gene for an outer membrane protein of Helicobacter pylori, encoded protein, antibodies; for diagnosis and therapy.
NIH (Natl. Inst. Hlth.) WO 97/28255 Prostate cell lines Bethesda, Md. Immortal human prostate epithelial cell lines; for diagnosis and treatment of prostate cancer.
NIH (Natl. Inst. Hlth.) WO 97/28258 HIV infection model Bethesda, Md. Cell lines coexpressing human CD4 and CXCR4, transgenics with these cells; for studying HIV infection.
NIH (Natl. Inst. Hlth.) WO 97/29183 T cell activation Bethesda, Md. Transformation of stem cells into dendritic cells; for antigen presentation for T cell activation.
NIH (Natl. Inst. Hlth.) WO 97/29195 Cancer therapy antigen Bethesda, Md. Normal melanogenic gene that encodes an antigenic cancer peptide recognized by T cells; for cancer therapy.
NIH (Natl. Inst. Hlth.) WO 97/29211 Differential mRNA display Bethesda, Md. Two-dimensional display of amplified cDNAs from differentially expressed mRNA sets; for cloning.
Netherlands Cancer Inst. WO 97/29202 Transposon-based vectors Amsterdam, Netherlands Vectors with transposon sequences and transposase activity; for gene therapy.
North American Vaccine WO 97/28273 Meningococcal vaccines Beltsville, Md. Expression of meningococcal outer membrane proteins in yeast; for immunostimulatory response and vaccines.
N. Sydney Area Hlth. Serv. WO 97/29191 Multidrug resistance gene St. Leonards, Australia Gene for a protein with anthracycline resistance activity; for affecting multidrug resistance.
Novo Nordisk Biotech WO 97/29197 Mutanases Davis, Calif. Genes for mutanases, encoded proteins, expression systems; for degrading oral mutan.
Oncormed WO 97/29213 BRCA1 gene coding sequences Gaithersburg, Md. Coding sequences of the BRCA1 gene; for identifying increased risk of cancer and performing gene therapy.
Paik, K.H. WO 97/27742 Viral antigen production Carlsbad, Calif. Production of viral antigens by infecting and culturing mitochondria-rich animal tissue.
Pasteur Inst. WO 97/29129 Hepatitis antibody diagnostic Lille, France Antibodies that bind to mature complexes of hepatitis C virus glycoproteins E1 and E2; for diagnostics.
Repligen WO 97/28267 Graft rejection inhibitor Needham, Mass. CTLA4-immunoglobulin fusion proteins; for suppression of immune response and inhibition of graft rejection.
Rhone-Poulenc Rorer WO 97/29196 Thymidine kinase variants Antony, France Thymidine kinase variants with ATP binding site, C-terminal and N-terminal mutations; for gene therapy.
Schering WO 97/29192 CC chemokine Kenilworth, N.J. Gene for a mammalian dendritic cell CC chemokine, encoded protein, antibodies; for diagnostics.
Somatix Therapy WO 97/28269 Transfected hematopoietic stem cells Alameda, Calif. Primary CD34+ hematopoietic stem cells; for expression of transfected genes.
Stratagene WO 97/28282 Cloning without restriction La Jolla, Calif. Techniques for conveniently manipulating genes without reliance on restriction enzyme sites.
Takeda EPO 789 076 Amygdaloid G protein receptor Osaka, Japan Gene for G protein-coupled receptor protein from human amygdaloid nucleus, encoded protein; for therapeutics.
Technologene WO 97/28272 Fusion protein vectors Sunnyvale, Calif. Recombinant vectors that allow the production of fusion proteins, expression and purification methods.
Therexsys WO 97/28818 Fusions for vaccines Keele, U.K. Fusion of an antigen encoding gene and an antigen; for uptake and expression in antigen-presenting cells.
Therexsys WO 97/29190 Pharmaceutical-grade DNA Keele, U.K. Production of pharmaceutical grade DNA from plasmid DNA from E. coli purified using raised pH.