Merck Sharp & Dohme LLC has disclosed phthalazine derivatives acting as NLRP3 inflammasome inhibitors reported to be useful for the treatment of atherosclerosis, nonalcoholic steatohepatitis (NASH; metabolic dysfunction-associated steatohepatitis [MASH]), neuroinflammation, inflammatory skin disease, inflammatory joint disease, autoimmune disease, Alzheimer’s disease and Parkinson’s disease, among others.