Omass Therapeutics Ltd. has described new melanocortin MC2 receptor antagonists reported to be useful for the treatment of congenital adrenal hyperplasia, Cushing syndrome, depression, ectopic ACTH syndrome, polycystic ovary syndrome and septic shock.

Suven Life Sciences Ltd. has disclosed new 2-amino-pyrimidine derivatives acting as muscarinic M4 receptor positive allosteric modulators (PAMs) reported to be useful for the treatment of pain, sleep disorders, depression, schizophrenia, Alzheimer’s, Parkinson’s and Huntington’s disease.

Treeline Biosciences Inc. has synthesized new proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase-binding moiety covalently linked to transcriptional enhancer factor TEF (TEAD)-targeting moiety potentially useful for the treatment of cancer.